Variable stoichiometry of proton pumping by the mitochondrial respiratory chain

Nature ◽  
1987 ◽  
Vol 329 (6135) ◽  
pp. 170-172 ◽  
Author(s):  
Michael P. Murphy ◽  
Martin D. Brand
Keyword(s):  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Proton Pumping ◽  
Variable Stoichiometry ◽  
Mitochondrial Respiratory

Revealing various coupling of electron transfer and proton pumping in mitochondrial respiratory chain

2013 ◽  
Vol 23 (4) ◽  
pp. 526-538 ◽  
Author(s):  
Fei Sun ◽  
Qiangjun Zhou ◽  
Xiaoyun Pang ◽  
Yingzhi Xu ◽  
Zihe Rao
Keyword(s):  
Electron Transfer ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Proton Pumping ◽  
Mitochondrial Respiratory

scholarly journals The road to the structure of the mitochondrial respiratory chain supercomplex

2020 ◽  
Vol 48 (2) ◽  
pp. 621-629
Author(s):  
Nikeisha J. Caruana ◽  
David A. Stroud
Keyword(s):  
Respiratory Chain ◽  
Large Body ◽  
Mitochondrial Respiratory Chain ◽  
Proton Pumping ◽  
Atp Production ◽  
Structural Characterisation ◽  
The Road ◽  
X Ray Crystallography ◽  
History Of ◽  
Mitochondrial Respiratory

The four complexes of the mitochondrial respiratory chain are critical for ATP production in most eukaryotic cells. Structural characterisation of these complexes has been critical for understanding the mechanisms underpinning their function. The three proton-pumping complexes, Complexes I, III and IV associate to form stable supercomplexes or respirasomes, the most abundant form containing 80 subunits in mammals. Multiple functions have been proposed for the supercomplexes, including enhancing the diffusion of electron carriers, providing stability for the complexes and protection against reactive oxygen species. Although high-resolution structures for Complexes III and IV were determined by X-ray crystallography in the 1990s, the size of Complex I and the supercomplexes necessitated advances in sample preparation and the development of cryo-electron microscopy techniques. We now enjoy structures for these beautiful complexes isolated from multiple organisms and in multiple states and together they provide important insights into respiratory chain function and the role of the supercomplex. While we as non-structural biologists use these structures for interpreting our own functional data, we need to remind ourselves that they stand on the shoulders of a large body of previous structural studies, many of which are still appropriate for use in understanding our results. In this mini-review, we discuss the history of respiratory chain structural biology studies leading to the structures of the mammalian supercomplexes and beyond.

Molecular diagnosis in mitochondrial respiratory chain deficiency using exome sequencing

2013 ◽  
Vol 44 (02) ◽  
Author(s):  
R Kopajtich ◽  
T Haack ◽  
B Haberberger ◽  
J Mayr ◽  
W Sperl ◽  
...  
Keyword(s):  
Exome Sequencing ◽  
Respiratory Chain ◽  
Molecular Diagnosis ◽  
Mitochondrial Respiratory Chain ◽  
Respiratory Chain Deficiency ◽  
Mitochondrial Respiratory

333-LB: Impact of Aging on Mitochondrial Respiratory Chain Expression and Pancreatic Islet Cell Composition by Using a Mitochondrial DNA Mutator Mouse Model

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 333-LB
Author(s):  
XUEFEI YU ◽  
CATHERINE ARDEN ◽  
CHUN CHEN ◽  
CARLA BRADSHAW ◽  
JULIA WHITEHALL ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Mouse Model ◽  
Respiratory Chain ◽  
Pancreatic Islet ◽  
Islet Cell ◽  
Mitochondrial Respiratory Chain ◽  
Pancreatic Islet Cell ◽  
Cell Composition ◽  
Mitochondrial Respiratory

Nanosized non-proteinaceous complexes III and IV mimicking electron transfer of mitochondrial respiratory chain

2021 ◽  
Author(s):  
Iago A. Modenez ◽  
Lucyano J.A. Macedo ◽  
Antonio F.A.A. Melo ◽  
Andressa R. Pereira ◽  
Osvaldo N. Oliveira Jr ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Respiratory Chain ◽  
Mitochondrial Respiratory Chain ◽  
Mitochondrial Respiratory
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