scholarly journals Influence of immune inflammation on androgen receptor expression in benign prostatic hyperplasia tissue

2011 ◽  
Vol 14 (2) ◽  
pp. 316-319 ◽  
Author(s):  
Zong-Lin Wu ◽  
Ya Yuan ◽  
He Geng ◽  
Shu-Jie Xia
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Benign Prostatic Hyperplasia Tissue ◽  
Immune Inflammation

scholarly journals Stereological analysis of androgen receptors in prostate cancer and benign prostatic hyperplasia

2018 ◽  
Vol 71 (3-4) ◽  
pp. 89-95
Author(s):  
Sandra Trivunic-Dajko ◽  
Jovo Bogdanovic ◽  
Sasa Vojinov ◽  
Andrejic Visnjic
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Prostatic Cancer ◽  
Androgen Receptors ◽  
Immunohistochemical Analysis ◽  
Prostatic Hyperplasia ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Stereological Analysis

Introduction. Through androgen receptors, androgens regulate prostate cellular growth and function, proliferation, differentiation, apoptosis, lipid metabolism and secretory activity, as well as development and progression of prostate cancer. Prostate cancer, and its primary glandular tissue are influenced by hormones, and it is used for therapeutic purposes. Anti-androgen treatment is carried out in patients with metastatic prostatic cancer, in order to block effects of androgens. Immunohistochemical analysis of androgen receptors in the prostate cancer tissue may help us to assume how the tumors will react to the anti-androgen therapy, if they are androgen-positive, -negative, or hormone resistant tumors. Knowledge of the presence of androgen receptors in the tumor tissue may be a prognostic indicator in histopathological analysis. The aim of this study was stereological evaluation of androgen receptor expression in patients with benign prostatic hyperplasia and in patients with prostatic cancer, before therapy. Material and Methods. Immunohistochemical analysis was carried out using anti-human androgen receptor monoclonal antibody 441. The presence and intensity of the androgen receptors were evaluated in 195 patients: 165 with benign prostatic hyperplasia and 30 with prostatic cancer using Weibel?s multi-purpose M 42 stereological test system. Material was obtained by needle biopsy or transurethral resection of the prostate. Results. All secretory cells in patients with benign prostatic hyperplasia were androgen positive, while in patients with prostatic cancer, all tumors were mostly androgen positive, some with foci of negativity. The resulting negative correlation with Gleason score and International Society of Urological Pathology grade was not statistically significant. Conclusion. Study results of stereological analysis of androgen receptors indicate that prior the therapy prostate cancer is androgendependent, with a high level of androgen receptor expression, although slightly lower compared to benign prostatic hyperplasia.

scholarly journals Androgen Receptor Expression in Epithelial and Stromal Cells of Prostatic Carcinoma and Benign Prostatic Hyperplasia

2017 ◽  
Vol 5 (5) ◽  
pp. 608-612
Author(s):  
Vanja Filipovski ◽  
Katerina Kubelka-Sabit ◽  
Dzengis Jasar ◽  
Vesna Janevska
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Epithelial Cells ◽  
Stromal Cells ◽  
Prostatic Carcinoma ◽  
Growth Control ◽  
Prostatic Hyperplasia ◽  
Receptor Expression ◽  
Stromal Microenvironment ◽  
Histological Score

BACKGROUND: Prostatic carcinoma (PCa) derives from prostatic epithelial cells. However stromal microenvironment, associated with malignant epithelium, also plays a role in prostatic carcinogenesis. Alterations in prostatic stromal cells contribute to the loss of growth control in epithelial cells that lead to progression of PCa.AIM: To analyse the differences between Androgen Receptor (AR) expression in both epithelial and stromal cells in PCa and the surrounding benign prostatic hyperplasia (BPH) and to compare the results with tumour grade.MATERIAL AND METHODS: Samples from 70 cases of radical prostatectomy specimens were used. The expression and intensity of the signal for AR was analysed in the epithelial and stromal cells of PCa and BPH, and the data was quantified using histological score (H-score).RESULTS: AR showed significantly lower expression in both epithelial and stromal cells of PCa compared to BPH. In PCa a significant positive correlation of AR expression was found between stromal and epithelial cells of PCa. AR expression showed a correlation between the stromal cells of PCa and tumour grade.CONCLUSION: AR expression is reduced in epithelial and stromal cells of PCa. Expression of AR in stromal cells of PCa significantly correlates with tumour grade.

The CAG Repeat Within the Androgen Receptor Gene and Benign Prostatic Hyperplasia

1999 ◽  
Vol 162 (1) ◽  
pp. 269-270
Author(s):  
E. Giovannucci ◽  
E.A. Platz ◽  
M.J. Stampfer ◽  
A. Chan ◽  
K. Krithivas ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Prostatic Hyperplasia ◽  
Cag Repeat
Sign in / Sign up

Export Citation Format

Share Document