scholarly journals Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes

2010 ◽  
Vol 31 (12) ◽  
pp. 1569-1575 ◽  
Author(s):  
Hong-jye Hong ◽  
Ju-chi Liu ◽  
Tzu-hurng Cheng ◽  
Paul Chan
Keyword(s):  
Angiotensin Ii ◽  
Tanshinone Iia ◽  
Neonatal Rat ◽  
Akt Pathway ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

Tanshinone IIA protects neonatal rat cardiomyocytes from adriamycin-induced apoptosis

2008 ◽  
Vol 151 (2) ◽  
pp. 79-87 ◽  
Author(s):  
Jie Gao ◽  
Guoqing Yang ◽  
Rongbiao Pi ◽  
Ruifang Li ◽  
Ping Wang ◽  
...  
Keyword(s):  
Tanshinone Iia ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

Propofol attenuates apoptosis induced by angiotensin II via the PI3-kinase/Akt pathway in neonatal rat cardiomyocytes

2011 ◽  
Vol 28 ◽  
pp. 45-46
Author(s):  
K. L. Wong ◽  
C. W. Cheung ◽  
E. C. So ◽  
Y. M. Leung ◽  
T. H. Cheng
Keyword(s):  
Angiotensin Ii ◽  
Pi3 Kinase ◽  
Neonatal Rat ◽  
Akt Pathway ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes

scholarly journals Aldosterone, but Not Angiotensin II, Reduces Angiotensin Converting Enzyme 2 Gene Expression Levels in Cultured Neonatal Rat Cardiomyocytes

2008 ◽  
Vol 72 (8) ◽  
pp. 1346-1350 ◽  
Author(s):  
Megumi Yamamuro ◽  
Michihiro Yoshimura ◽  
Masafumi Nakayama ◽  
Koji Abe ◽  
Hitoshi Sumida ◽  
...  
Keyword(s):  
Gene Expression ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Neonatal Rat ◽  
Converting Enzyme ◽  
Rat Cardiomyocytes ◽  
Angiotensin Converting Enzyme 2 ◽  
Expression Levels ◽  
Neonatal Rat Cardiomyocytes ◽  
Gene Expression Levels

Nitric oxide signaling in stretch‐induced apoptosis of neonatal rat cardiomyocytes

2006 ◽  
Vol 20 (11) ◽  
pp. 1883-1885 ◽  
Author(s):  
Xudong Liao ◽  
Jun‐Ming Liu ◽  
Lei Du ◽  
Aihui Tang ◽  
Yingli Shang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Nitric Oxide Signaling ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

Cysteinyl leukotriene-dependent [Ca2+]iresponses to angiotensin II in cardiomyocytes

2003 ◽  
Vol 284 (4) ◽  
pp. H1269-H1276 ◽  
Author(s):  
Pinggang Liu ◽  
Derek A. Misurski ◽  
Venkat Gopalakrishnan
Keyword(s):  
Angiotensin Ii ◽  
Single Cells ◽  
Receptor Activation ◽  
Neonatal Rat ◽  
Ang Ii ◽  
Rat Cardiomyocytes ◽  
Endothelin 1 ◽  
Neonatal Rat Cardiomyocytes ◽  
Cysteinyl Leukotriene

With the use of fura 2 measurements in multiple and single cells, we examined whether cysteinyl leukotrienes (CysLT) mediate angiotensin II (ANG II)-evoked increases in cytosolic free Ca2+ concentration ([Ca2+]i) in neonatal rat cardiomyocytes. ANG II-evoked CysLT release peaked at 1 min. The angiotensin type 1 (AT1) antagonist losartan, but not the AT2antagonist PD-123319, attenuated the elevations in [Ca2+]i and CysLT levels evoked by ANG II. Vasopressin and endothelin-1 increased [Ca2+]i but not CysLT levels. The 5-lipoxygenase (5-LO) inhibitor AA-861 and the CysLT1-selective antagonist MK-571 reduced the maximal [Ca2+]i responses to ANG II but not to vasopressin and endothelin-1. While MK-571 reduced the responses to leukotriene D4 (LTD4), the dual CysLT antagonist BAY-u9773 completely blocked the [Ca2+]i elevation to both LTD4and LTC4. These data confirm that ANG II-evoked increases, but not vasopressin- and endothelin-1-evoked increases, in [Ca2+]i involve generation of the 5-lipoxygenase metabolite CysLT. The inositol (1,4,5)-trisphosphate [Ins(1,4,5)P3] antagonist 2-aminoethoxydiphenyl borate attenuated the [Ca2+]i responses to ANG II and LTD4. Thus AT1 receptor activation by ANG II is linked to CysLT-mediated Ca2+ release from Ins(1,4,5)P3-sensitive intracellular stores to augment direct ANG II-evoked Ca2+ mobilization in rat cardiomyocytes.

Minoxidil Attenuates Ischemia-Induced Apoptosis in Cultured Neonatal Rat Cardiomyocytes

2004 ◽  
Vol 43 (6) ◽  
pp. 789-794 ◽  
Author(s):  
Tomoka Takatani ◽  
Kyoko Takahashi ◽  
Chengshi Jin ◽  
Takahisa Matsuda ◽  
Xinyao Cheng ◽  
...  
Keyword(s):  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis

L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes

2011 ◽  
Vol 146 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Hung-Hsin Chao ◽  
Ju-Chi Liu ◽  
Hong-Jye Hong ◽  
Jia-wei Lin ◽  
Cheng-Hsien Chen ◽  
...  
Keyword(s):  
Neonatal Rat ◽  
Rat Cardiomyocytes ◽  
Neonatal Rat Cardiomyocytes ◽  
Induced Apoptosis
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