scholarly journals Body composition and body fat distribution are related to cardiac autonomic control in non-alcoholic fatty liver disease patients

2013 ◽  
Vol 68 (2) ◽  
pp. 241-246 ◽  
Author(s):  
N M Pimenta ◽  
H Santa-Clara ◽  
H Cortez-Pinto ◽  
J Silva-Nunes ◽  
M da Lapa Rosado ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Fat ◽  
Fatty Liver Disease ◽  
Fat Distribution ◽  
Autonomic Control ◽  
Alcoholic Fatty Liver ◽  
Cardiac Autonomic Control ◽  
Alcoholic Fatty Liver Disease

scholarly journals Relationship Between Body Composition and the Histology of Non-alcoholic Fatty Liver Disease: A Cross-sectional Study 

2021 ◽  
Author(s):  
Teruki Miyake ◽  
Masumi Miyazaki ◽  
Osamu Yoshida ◽  
Sayaka Kanzaki ◽  
Hironobu Nakaguchi ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Muscle Mass ◽  
Fat Mass ◽  
Visceral Fat ◽  
Fatty Liver Disease ◽  
Visceral Fat Area ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background: Causes of non-alcoholic fatty liver disease and its progression include visceral fat accumulation and loss of muscle mass; however, which is more critical is unclear. To clarify this, we examined the relationship between body composition and non-alcoholic fatty liver disease progression as indicated by fibrosis and the non-alcoholic fatty liver disease activity score.Methods: This cross-sectional study comprised 139 patients (54 men; age, 20–76 years) treated for non-alcoholic fatty liver disease between December 2010 and January 2020. Body composition measurements, histological examinations of liver samples, and comprehensive blood chemistry tests were performed. The relationship between body composition and non-alcoholic fatty liver disease histology findings was analyzed using the logistic regression model.Results: Fibrosis was significantly and inversely correlated with muscle mass and appendicular skeletal muscle mass and significantly and positively correlated with fat mass, fat mass/height squared, visceral fat area, and waist-hip ratio (P <0.05). After adjustment for sex, blood chemistry measurements, and body composition indices, fibrosis remained associated with appendicular skeletal muscle mass, fat mass, fat mass/height squared, and visceral fat area (P <0.05). Non-alcoholic fatty liver disease activity score ≥5 significantly correlated with fat mass and fat mass/height squared in a univariate but not multivariate analysis.Conclusions: Fibrosis in non-alcoholic fatty liver disease, an indicator of unfavorable long-term outcomes, is associated with more indices of fat mass than of those of muscle mass. Hence, fat mass should be controlled to prevent non-alcoholic fatty liver disease progression.

scholarly journals Non-alcoholic Fatty Liver Disease and Postoperative Hypothyroidism in Women: Clinical and Pathogenetic Parallels

2021 ◽  
Vol 17 (16) ◽  
pp. 40-45
Author(s):  
G.S. Dzhulay ◽  
◽  
S.V. Shchelochenkov ◽  
O.N. Guskova ◽  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Disorders ◽  
Fat Distribution ◽  
Atherogenic Dyslipidemia ◽  
Alcoholic Fatty Liver ◽  
Liver Disorders ◽  
Alcoholic Fatty Liver Disease

Objective – to establish the clinical and pathogenetic patterns of the formation and course of non-alcoholic fatty liver disease in women with postoperative hypothyroidism. Material and methods. In a single-stage study of the "case-control" type of 170 women (Me aged 50 years), anthropometric data, parameters of carbohydrate, lipid, and protein metabolism, liver function tests were studied in the presence and absence of postoperative hypothyroidism. Results. It was found that in 86.2% of women with postoperative hypothyroidism, non-alcoholic fatty liver disease develops mainly in the form of steatohepatosis without distinct functional liver disorders. Insulin resistance and atherogenic dyslipidemia are found in the vast majority of them, the degree of their severity is determined by the presence of excess body weight with android and intermediate types of fat distribution. The greatest diagnostic value in the aspect of the probability of developing non-alcoholic fatty liver disease and metabolic disorders have a body mass index of Ketle and the ratio of the waist to the circumference of the hips. For the detection of metabolic disorders, the most significant insulin resistance index HOMA-IR, HDL, VLDL, ApoB, ApoB/ApoA1 index. Conclusion. In women with postoperative hypothyroidism in 86.2% of cases non-alcoholic fatty liver disease develops mainly in the form of steatohepatosis, characterized by a oligosymptomatic course without distinct functional liver disorders, the development of insulin resistance and atherogenic dyslipidemia, the severity of which is determined by the body mass index and the type of fat distribution

scholarly journals Body Composition and Non-alcoholic Fatty Liver Disease

2016 ◽  
Vol 6 (1) ◽  
pp. 47-48 ◽  
Author(s):  
Ludovico Abenavoli ◽  
Laura Di Renzo ◽  
Antonino De Lorenzo
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Hypovitaminosis D is associated with increased whole body fat mass and greater severity of non-alcoholic fatty liver disease

2013 ◽  
Vol 34 (6) ◽  
pp. e118-e127 ◽  
Author(s):  
Jaividhya Dasarathy ◽  
Pranav Periyalwar ◽  
Sanath Allampati ◽  
Vikram Bhinder ◽  
Carol Hawkins ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Body Fat ◽  
Fat Mass ◽  
Fatty Liver Disease ◽  
Hypovitaminosis D ◽  
Whole Body ◽  
Body Fat Mass ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

scholarly journals Relationship between body composition and the histology of non‐alcoholic fatty liver disease: a cross‐sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Teruki Miyake ◽  
Masumi Miyazaki ◽  
Osamu Yoshida ◽  
Sayaka Kanzaki ◽  
Hironobu Nakaguchi ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Muscle Mass ◽  
Fat Mass ◽  
Visceral Fat ◽  
Fatty Liver Disease ◽  
Visceral Fat Area ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Abstract Background Causes of non-alcoholic fatty liver disease and its progression include visceral fat accumulation and loss of muscle mass; however, which of the two phenomena is more critical is unclear. Therefore, we intended to examine the relationship between body composition and non-alcoholic fatty liver disease progression as indicated by fibrosis and the non-alcoholic fatty liver disease activity score. Methods This cross-sectional study comprised 149 patients (55 men; age, 20–76 years) treated for non-alcoholic fatty liver disease between December 2010 and January 2020. Body composition measurements, histological examinations of liver samples, and comprehensive blood chemistry tests were performed. The relationship between body composition and non-alcoholic fatty liver disease histology findings was analyzed using the logistic regression model. Results Fibrosis was significantly and inversely correlated with muscle mass and appendicular skeletal muscle mass and significantly and positively correlated with fat mass, fat mass/height squared, visceral fat area, and waist-hip ratio (P < 0.05). After adjustment for sex, blood chemistry measurements, and body composition indices, fibrosis remained associated with appendicular skeletal muscle mass, fat mass, fat mass/height squared, and visceral fat area (P < 0.05). Non-alcoholic fatty liver disease activity score ≥ 5 significantly correlated with fat mass and fat mass/height squared in a univariate but not multivariate analysis. Conclusions Fibrosis in non-alcoholic fatty liver disease, an indicator of unfavorable long-term outcomes, is associated with more indices of fat mass than of those of muscle mass. Hence, fat mass should be controlled to prevent non-alcoholic fatty liver disease progression.

Body composition, phenotype and central obesity indices in Egyptian women with non-alcoholic fatty liver disease

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Moushira Zaki ◽  
Darine Amin ◽  
Ramy Mohamed
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Body Fat ◽  
Fatty Liver Disease ◽  
Central Obesity ◽  
Visceral Adiposity Index ◽  
Alcoholic Fatty Liver ◽  
Egyptian Women ◽  
Obesity Indices

AbstractObjectivesNonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The aim of this study is to investigate body composition and phenotype of Egyptian women with non-alcoholic fatty liver disease (NAFLD) and compare with those without and determine the optimal cut-off values of central obesity indices for predicting NAFLD.MethodsThe study included 100 women with NAFLD and 100 age and sex matched healthy controls without NAFLD. All women were subjected to ultrasonography examination. Anthropometric measurements included weight, height, waist circumference (WC), hip circumference (HC) and skinfolds thickness were assessed for all participants. Body fat % was evaluated by Tanita body composition analyzer. Body mass index (BMI), WC / height ratio (WHtR), WC / HC ratio (WHR) and visceral adiposity index (VAI) were calculated. Receiver-operating characteristic (ROC) curve was used to determine the optimal cut-off values.ResultsData showed significant higher levels of WHtR, WHR, BMI, sum of skinfolds, body fat %, serum fasting blood lipids and glucose in NAFLD women compared to group of patients without NAFLD. The area under curve (AUC) was 0.920 for VIA, 0.883 for WHtR and 0.647 for WHR. The optimal cutoff value of VAI was 3.66, of WHtR was 0.66 and WHR was 0.84. All values showed high sensitivity and specificity values.ConclusionNAFLD women were obese, had excess subcutaneous fat and body fat ratio. Central obesity indices are closely associated with the presence of NAFLD in Egyptian women and might be responsible for its development. Visceral adiposity index had superior diagnostic performance.

scholarly journals Fat mass to fat-free mass ratio and the risk of non-alcoholic fatty liver disease and fibrosis in non-obese and obese individuals

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Huajie Dai ◽  
Jiali Xiang ◽  
Yanan Hou ◽  
Liping Xuan ◽  
Tiange Wang ◽  
...  
Keyword(s):  
Body Composition ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fat Mass ◽  
Fatty Liver Disease ◽  
Fat Free Mass ◽  
Obese Women ◽  
Alcoholic Fatty Liver ◽  
Obesity Status ◽  
Alcoholic Fatty Liver Disease

Abstract Context Body composition may explain partially why non-obese individuals still at the risk of developing non-alcoholic fatty liver disease (NAFLD). The ratio of fat mass to fat-free mass (FM/FFM) has been proposed to assess the combined effect of different body compositions. Objective We aimed to investigate the associations of FM/FFM ratio with the risk of developing NAFLD and fibrosis and to identify the potential mediators according to obesity status. Methods This cohort study comprised 3419 adults age ≥ 40 years and free of NAFLD at baseline. Body composition was measured by bioelectrical impedance analysis. NAFLD was ascertained by ultrasonography and fibrosis was assessed by non-invasive score systems. Results For each 1 standard deviation increment in FM/FFM ratio, the odds ratio for the risk of NAFLD was 1.55 (95% confidence interval [CI] 1.23–1.95) in non-obese men, 1.33 (95% CI 1.08–1.65) in obese men, 1.42 (95% CI 1.44–1.67) in non-obese women, and 1.29 (95% CI 1.12–1.50) in obese women. Similar associations were also found between FM/FFM ratio and NAFLD with fibrosis. Mediation analysis showed that insulin resistance, triglycerides, high-density lipoprotein cholesterol, white blood cells, and total cholesterol mediated the association of FM/FFM ratio with NAFLD risk in specific sex and obesity subgroups. Conclusions The FM/FFM ratio significantly associated with the NAFLD and fibrosis risk in both non-obese and obese individuals. Different factors may mediate the association between body composition and NAFLD risk according to different obesity status.

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