The impact of pulse wave velocity in a Japanese population with metabolic syndrome

Introduction: Accumulating evidence indicated that high parathyroid hormone (PTH) is associated with increased cardiovascular risk. The impact of PTH on vascular structure and function is, however, still unclear. We evaluated the relationship between pulse wave velocity (PWV) as a novel index of arterial stiffness and circulating levels of PTH in patients with PTH-excess (primary hyperparathyroidism (pHPT)). Methods and Results: We analyzed baseline data of the ongoing randomized, double-blind, placebo-controlled “Effect of Eplerenone on Parathyroid Hormone Levels in Patients with Primary Hyperparathyroidism” (EPATH) study. Inclusion criteria were age of at least 18 years and a diagnosis of pHPT according to international guidelines. Standardized blood sampling was performed after an overnight fast and 24h PWV was measured by a validated non-invasive device for ambulatory hemodynamic monitoring (Mobil O Graph, I.E.M., Stolberg, Germany). Our analysis comprised 92 pHPT patients with a mean age of 68.5 +/- 9.7 years (71 % females) and a median PTH of 102 (IQR 81 - 132) pg/ml. Mean 24h PWV was 9.8 +/- 1.8 m/s, mean daytime and mean nighttime PWV were 10.0 +/- 1.7 m/s and 9.6 +/- 1.8 m/s, respectively. In multivariate linear regression analyses adjusted for age, sex, body mass index, smoking status, mean systolic and mean diastolic 24h blood pressure, antihypertensive medication, type 2 diabetes, 25-hydroxyvitamin D, serum calcium, intake of cinacalcet and fasting serum cholesterol PTH emerged as a strong predictor of mean 24h PWV (ß=0.30, p=0.012), daytime PWV and nighttime PWV (ß=0.30, p=0.011 and ß=0.30, p=0.019, respectively). Conclusion: In a selective cohort of patients with pHPT plasma PTH was strongly related to 24h PWV. These data strengthen the notion that PTH may impact on vascular function. Interventional and mechanistic trials are needed to evaluate modulatory effects on vasculature in patients with high PTH.

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Blood Pressure and Body Weight Have Different Effects on Pulse Wave Velocity and Cardiac Mass in Children

Journal of Clinical Medicine ◽

10.3390/jcm9092954 ◽

2020 ◽

Vol 9 (9) ◽

pp. 2954

Author(s):

Simonetta Genovesi ◽

Paolo Salvi ◽

Elisa Nava ◽

Elena Tassistro ◽

Marco Giussani ◽

...

Keyword(s):

Blood Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Left Ventricular ◽

Cardiac Mass ◽

Excess Weight ◽

Gold Standard Method ◽

Z Scores ◽

The Impact

Background: High blood pressure (BP) and excess weight can lead to early cardiovascular organ damage already in children. Carotid-femoral pulse wave velocity (cf-PWV) is the non-invasive gold standard method for assessing aortic stiffness, while carotid-radial PWV (cr-PWV) provides information on the distensibility of the upper limb arteries. The aim of this study was to evaluate the relationship of BP and BMI z-scores with arterial stiffness and left ventricular mass index (LVMI) in a pediatric population. Methods: In 343 children (57.7% males; age ± SD 11.7 ± 2.9 years), systolic (SBP) and diastolic (DBP) BP, BMI, cf-PWV, cr-PWV and LVMI were measured. A multiple linear regression model was used to assess the impact of BMI and SBP (or DBP) z-scores on cf-PWV, cr-PWV and LVMI. Results: About 21% of children were normal weight, 34% were overweight and 45% obese. Adjusted for possible confounders, SBP and DBP z-scores were significantly associated with cf-PWV (p < 0.001), while only DBP z-scores were related to cr-PWV (p < 0.01). BMI was neither associated with cf-PWV nor with cr-PWV values but was a strong predictor of LVMI (<0.001), whereas cardiac mass and BP z-scores were not related. Conclusions: Our study suggests that, in children, elevated BP values and excess weight may have different effects on the heart and the vessels in causing early cardiovascular alterations.

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THE IMPACT OF ANTIANGIOGENIC TREATMENT OF METASTATIC RENAL CELL CARCINOMA ON CENTRAL BLOOD PRESSURE AND PULSE WAVE VELOCITY

Journal of Hypertension ◽

10.1097/01.hjh.0000571776.00918.a6 ◽

2019 ◽

Vol 37 ◽

pp. e137

Author(s):

D. Lipski ◽

P. Uruski ◽

P. Tomczak ◽

R. Ramlau ◽

A. Tykarski

Keyword(s):

Blood Pressure ◽

Renal Cell Carcinoma ◽

Pulse Wave Velocity ◽

Cell Carcinoma ◽

Wave Velocity ◽

Metastatic Renal Cell Carcinoma ◽

Renal Cell ◽

Pulse Wave ◽

Antiangiogenic Treatment ◽

The Impact

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Two New Criteria of the Metabolic Syndrome: Prevalence and the Association with Brachial‐Ankle Pulse Wave Velocity in Japanese Male Workers

Journal of Occupational Health ◽

10.1539/joh.48.134 ◽

2006 ◽

Vol 48 (2) ◽

pp. 134-140 ◽

Cited By ~ 9

Author(s):

Koichi Miyaki ◽

Asako Hara ◽

Mariko Naito ◽

Toru Naito ◽

Takeo Nakayama

Keyword(s):

Metabolic Syndrome ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

The Metabolic Syndrome ◽

Japanese Male ◽

New Criteria ◽

Male Workers

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Disassociation of aortic pulse wave velocity and augmentation index in patients with metabolic syndrome: should we blame inflammation?

Blood Pressure ◽

10.3109/08037051.2015.1116261 ◽

2015 ◽

Vol 25 (3) ◽

pp. 196-197 ◽

Cited By ~ 2

Author(s):

Theodore G. Papaioannou ◽

Charalambos Vlachopoulos ◽

Dimitrios Tousoulis

Keyword(s):

Metabolic Syndrome ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Augmentation Index ◽

Aortic Pulse Wave Velocity

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Metabolic Syndrome Including Glycated Hemoglobin A1c in Adults: Is It Time to Change?

Journal of Clinical Medicine ◽

10.3390/jcm8122090 ◽

2019 ◽

Vol 8 (12) ◽

pp. 2090

Author(s):

Iván Cavero-Redondo ◽

Vicente Martínez-Vizcaíno ◽

Celia Álvarez-Bueno ◽

Cristina Agudo-Conde ◽

Cristina Lugones-Sánchez ◽

...

Keyword(s):

Metabolic Syndrome ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Goodness Of Fit ◽

Pulse Wave ◽

Clinical Performance ◽

Intima Media Thickness ◽

Vascular Damage ◽

Creatinine Ratio ◽

Single Factor

(1) Background: To assess the suitability of replacing conventional markers used for insulin resistance and dysglycemia by HbA1c in both the quantitative and qualitative metabolic syndrome (MetS) definition criteria; (2) Methods: Confirmatory factorial analysis was used to compare three quantitative definitions of MetS that consisted of many single-factor models, one of which included HbA1c as the dysglycemia indicator. After that, the model with the better goodness-of-fit was selected. Furthermore, a new MetS qualitative definition was proposed by replacing fasting plasma glucose with HbA1c > 5.7% in the International Diabetes Federation (IDF) definition. The clinical performance of these two MetS criteria (IDF and IDF-modified including HbA1c as the dysglycemia indicator) to predict vascular damage (pulse wave velocity [PWv], intima media thickness [IMT] and albumin-to-creatinine ratio [ACR]) was estimated; (3) Results: The single-factor model including HbA1c showed the better goodness-of-fit (χ2 = 2.45, df = 2, p = 0.293, CFI = 0.999, SRMR = 0.010). Additionally, the IDF-modified criteria gained in clinical performance to predict vascular damage (diagnostic Odds Ratio: 6.94, 1.34 and 1.90) for pulse wave velocity (PWv), intima media thickness (IMT) and albumin-to-creatinine ratio (ACR), respectively; and (4) Conclusions: These data suggest that HbA1c could be considered as a useful component to be included in the MetS definition.

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