scholarly journals Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury

2011 ◽  
Vol 36 (8) ◽  
pp. 1062-1071 ◽  
Author(s):  
H Tokuyama ◽  
S Wakino ◽  
Y Hara ◽  
N Washida ◽  
K Fujimura ◽  
...  
Keyword(s):  
Renal Injury ◽  
Mineralocorticoid Receptor ◽  
Rho Kinase ◽  
Kinase Pathway

Critical role of the Rho-kinase pathway in TGF-β2-dependent collagen gel contraction by retinal pigment epithelial cells

2006 ◽  
Vol 82 (5) ◽  
pp. 849-859 ◽  
Author(s):  
Muneki Miura ◽  
Yasuaki Hata ◽  
Kumiko Hirayama ◽  
Takeshi Kita ◽  
Yoshihiro Noda ◽  
...  
Keyword(s):  
Retinal Pigment Epithelial ◽  
Retinal Pigment ◽  
Critical Role ◽  
Rho Kinase ◽  
Collagen Gel ◽  
Retinal Pigment Epithelial Cells ◽  
Collagen Gel Contraction ◽  
Kinase Pathway ◽  
Pigment Epithelial Cells

scholarly journals 0307 Role of vascular mineralocorticoid receptor in renal injury induced by ischemia/reperfusion

2014 ◽  
Vol 6 ◽  
pp. 52
Author(s):  
Jonatan Barrera-Chimal ◽  
Sonia Prince ◽  
Soumaya El Moghrabi ◽  
Norma Bobadilla ◽  
Fouad Fadel ◽  
...  
Keyword(s):  
Renal Injury ◽  
Mineralocorticoid Receptor ◽  
Ischemia Reperfusion

Effect of changes in pH on wall tension in isolated rat pulmonary artery: role of the RhoA/Rho-kinase pathway

2004 ◽  
Vol 287 (4) ◽  
pp. L673-L684 ◽  
Author(s):  
Jean-Marc Hyvelin ◽  
Clare O’Connor ◽  
Paul McLoughlin
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Kinase Inhibitor ◽  
Pulmonary Arteries ◽  
Rho Kinase ◽  
Systemic Circulation ◽  
Pulmonary Vasculature ◽  
Tension Development ◽  
Kinase Pathway

Pulmonary arteries (PA) are resistant to the vasodilator effects of extracellular acidosis in systemic vessels; the mechanism underlying this difference between systemic and pulmonary circulations has not been elucidated. We hypothesized that RhoA/Rho-kinase-mediated Ca2+ sensitization pathway played a greater role in tension development in pulmonary than in systemic vascular smooth muscle and that this pathway was insensitive to acidosis. In arterial rings contracted with the α1-agonist phenylephrine (PE), the Rho-kinase inhibitor Y-27632 (≤3 μM) induced greater relaxation in precontracted PA rings than in aortic rings. In PA rings stimulated by PE, the activation of RhoA was greater than in aorta. Normocapnic acidosis (NA) induced a smaller relaxation in precontracted PA than in aorta. However, in the presence of nifedipine and thapsigargin, when PE-induced contraction was predominantly mediated by Rho-kinase, the relaxant effect of NA was reduced and similar in both vessel types. Furthermore, in the presence of Y-27632, NA induced a greater relaxation in both PA and aorta, which was similar in both vessels. Finally, in α-toxin-permeabilized smooth muscle, PE-induced contraction at constant Ca2+ activity was inhibited by Y-27632 and unaffected by acidosis. These results indicate that Ca2+ sensitization induced by the RhoA/Rho-kinase pathway played a greater role in agonist-induced vascular smooth muscle contraction in PA than in aorta and that tension mediated by this pathway was insensitive to acidosis. The predominant role of the RhoA/Rho-kinase pathway in the pulmonary vasculature may account for the resistance of this circulation to the vasodilator effect of acidosis observed in the systemic circulation.

scholarly journals Alkannin Inhibited Hepatic Inflammation in Diabetic Db/Db Mice

2018 ◽  
Vol 45 (6) ◽  
pp. 2461-2470 ◽  
Author(s):  
Wenhua Xue ◽  
Zhirui Fan ◽  
Yuanzhe Li ◽  
Lifeng Li ◽  
Tengfei Zhang ◽  
...  
Keyword(s):  
Western Blotting ◽  
Tumour Necrosis ◽  
Rho Kinase ◽  
Hepatic Inflammation ◽  
Tnf Α ◽  
Hepatoprotective Effects ◽  
Kinase Pathway ◽  
Necrosis Factor ◽  
Pro Inflammatory Cytokines

Background/Aims: The current study was designed to investigate the protective role of alkannin (ALK) on liver injury in diabetic C57BL/KsJ-db/db mice and explore its potential mechanisms. Methods: An oral glucose tolerance test (OGTT) was performed. The levels of insulin, alanine aminotransferase (ALT), aspartate aminotransaminase (AST), total cholesterol (TC) and triglyceride (TG) were determined by commercial kits. The pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were determined by ELISA. The levels of the ROCK/NF-κB pathway were determined by Western blotting. Results: The contents of pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α were inhibited by ALK, metformin or fasudil in diabetic db/db mice. Further, Western blotting analysis showed that the expression of Rho, ROCK1, ROCK2, p-NF-κBp65, and p-IκBα was significantly reversed by ALK treatment. In human hepatic HepG2 cells, the hepatoprotective effects of ALK were further characterized. With response to palmitic acid-challenge, increased amounts of insulin, ALT, AST, TG, and TC were observed, whereas ALK pretreatment significantly inhibited their leakage in HepG2 cells without appreciable cytotoxic effects. The inflammation condition was recovered with ALK treatment as shown by changes of IL-1β, IL-6 and TNF-α. Further, Western blotting analysis also suggested that ALK improves hepatic inflammation in a Rho-kinase pathway. Conclusion: The present study successfully investigated the role of Rho-kinase signalling in diabetic liver injury. ALK exhibited hepatoprotective effects in diabetic db/db mice, and it might act through improving hepatic inflammation through the Rho-kinase pathway.

The Role of Rho/Rho-Kinase Pathway in the Expression of ICAM-1 by Linoleic Acid in Human Aortic Endothelial Cells

Inflammation ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 1041-1048 ◽  
Author(s):  
Chang Hee Jung ◽  
Woo Je Lee ◽  
Jenie Yoonoo Hwang ◽  
So Mi Seol ◽  
Yun Mi Kim ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Linoleic Acid ◽  
Rho Kinase ◽  
Aortic Endothelial Cells ◽  
Human Aortic Endothelial Cells ◽  
Kinase Pathway ◽  
Aortic Endothelial

Involvement of microglial RhoA/Rho-Kinase pathway activation in the dopaminergic neuron death. Role of angiotensin via angiotensin type 1 receptors

2012 ◽  
Vol 47 (2) ◽  
pp. 268-279 ◽  
Author(s):  
Begoña Villar-Cheda ◽  
Antonio Dominguez-Meijide ◽  
Belen Joglar ◽  
Ana I. Rodriguez-Perez ◽  
Maria J. Guerra ◽  
...  
Keyword(s):  
Dopaminergic Neuron ◽  
Rho Kinase ◽  
Neuron Death ◽  
Pathway Activation ◽  
Kinase Pathway ◽  
Angiotensin Type

The Role of the RhoA/rho-kinase Pathway in Pulmonary Hypertension

2009 ◽  
Vol 6 (1) ◽  
pp. 59-71 ◽  
Author(s):  
Bobby Nossaman ◽  
Philip Kadowitz
Keyword(s):  
Pulmonary Hypertension ◽  
Rho Kinase ◽  
Kinase Pathway

scholarly journals Rho-Kinase Inhibition Attenuates Acute Hypoxic Fetoplacental Vasoconstriction in the Rat

2012 ◽  
pp. S43-S48 ◽  
Author(s):  
P. KAFKA ◽  
O. VAJNEROVÁ ◽  
J. HERGET ◽  
V. HAMPL
Keyword(s):  
Calcium Influx ◽  
Acute Hypoxia ◽  
Rho Kinase ◽  
Calcium Sensitization ◽  
Constant Flow Rate ◽  
Vascular Beds ◽  
Kinase Signaling Pathway ◽  
Kinase Pathway ◽  
Hypoxic Gas Mixture

The vessels on the fetal side of the placenta differ from most other vascular beds except the lungs in that they respond to acute hypoxia by vasoconstriction. An essential role of calcium influx in the mechanism of this hypoxic fetoplacental vasoconstriction (HFPV) has been shown previously. That finding does not, however, exclude the possible involvement of other mechanisms of vascular tone regulation. In this study we tested the hypothesis that Rho-kinase-mediated calcium sensitization is involved in HFPV. We used a model of isolated rat placenta dually perfused (from both the maternal and fetal side) with Krebs salt solution saturated with normoxic and hypoxic gas mixture respectively at constant flow rate. Rho-kinase pathway was inhibited by fasudil (10 μM). We found that fasudil reduced basal normoxic fetoplacental vascular resistance and completely prevented HFPV. This suggests that the activity of Rho-kinase signaling pathway is essential for HFPV.

scholarly journals Altered ureteral contractility with ageing: Role of the rho-kinase pathway

2018 ◽  
Vol 171 ◽  
pp. 31-36 ◽  
Author(s):  
Iris Lim ◽  
Russ Chess-Williams ◽  
Donna Sellers
Keyword(s):  
Rho Kinase ◽  
Kinase Pathway
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