Relationship of ankle–brachial index with all-cause mortality and cardiovascular mortality after a 3-year follow-up: the China ankle–brachial index cohort study

ObjectivesTo examine the relationships of late-career physical heaviness of work and sitting at work with mortality. A national-level job exposure matrix was used to determine the occupation-specific level of physical heaviness and sitting.DesignProspective cohort study between years 1990 and 2015.SettingCommunity.Participants5210 men and 4725 women from the Helsinki Birth Cohort Study with an occupational code at baseline (ages 45–57 years).Primary and secondary outcome measuresTotal, cardiovascular (International Classification of Diseases 10th Revision I00–I99), cancer (C00–C97) and external (S00–Y84) mortality.ResultsThe exposures, physical heaviness and sitting had a non-linear, inverse relationship. During the 26-year follow-up, 1536 men and 759 women died. Among men, physical heaviness of work was positively associated and sitting at work was negatively associated with all-cause, cardiovascular and external cause mortality but they were not associated with cancer mortality. The HRs for men in the highest quartile of physical heaviness of work compared with men in the lowest quartile were 1.54 (1.31–1.80) for all-cause mortality, 1.70 (1.30–2.23) for cardiovascular mortality and 3.18 (1.75–5.78) for external cause mortality (adjusted for age and years of education). Compared with the lowest quartile, the HRs for the highest quartile of sitting at work among men were 0.71 (0.61–0.82) for all-cause mortality, 0.59 (0.45–0.77) for cardiovascular mortality and 0.38 (0.22–0.66) for external cause mortality. In women, neither physical heaviness of work nor sitting at work was associated with mortality.ConclusionsMen in physically heavy work at their late-work career are at higher risk of death than men in physically light work.

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Associations of Symptomatic or Asymptomatic Peripheral Arterial Disease with All-Cause and Cardiovascular Mortality after 3 Years Follow Up: The China Ankle-Brachial Index Cohort Study

Journal of Hypertension Open Access ◽

10.4172/2167-1095.1000124 ◽

2013 ◽

Vol 02 (03) ◽

Author(s):

Xiankai Li Yidong Wei ◽

DachunXu Yang Han ◽

Chang Liang Jianying Shen

Keyword(s):

Cohort Study ◽

Peripheral Arterial Disease ◽

Cardiovascular Mortality ◽

Ankle Brachial Index ◽

Arterial Disease ◽

Peripheral Arterial

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Change in ankle–brachial index and mortality among individuals with chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort Study

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa246 ◽

2020 ◽

Author(s):

Kirsten S Dorans ◽

Hua He ◽

Jing Chen ◽

Mirela Dobre ◽

Alan S Go ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Cohort Study ◽

Kidney Disease ◽

Renal Insufficiency ◽

Chronic Renal Insufficiency ◽

Ankle Brachial Index ◽

Annual Change ◽

All Cause Mortality ◽

Average Annual Change

Abstract Background Patients with chronic kidney disease (CKD) have an increased risk of peripheral arterial disease (PAD). The ankle–brachial index (ABI), a noninvasive measure of PAD, is a predictor of adverse events among individuals with CKD. In general populations, changes in ABI have been associated with mortality, but this association is not well understood among patients with CKD. Methods We conducted a prospective study of 2920 participants in the Chronic Renal Insufficiency Cohort Study without lower extremity revascularization or amputation at baseline and with at least one follow-up ABI measurement (taken at annual visits) during the first 4 years of follow-up. The ABI was obtained by the standard protocol. Results In Cox proportional hazard regression analyses, we found a U-shaped association of average annual change in ABI with all-cause mortality. After adjusting for baseline ABI and other covariates, compared with participants with an average annual change in ABI of 0–<0.02, individuals with an average annual change in ABI <−0.04 or ≥0.04 had multivariable-adjusted hazard ratios (HRs) of 1.81 [95% confidence interval (CI) 1.34–2.44) and 1.42 (95% CI 1.12–1.82) for all-cause mortality, respectively. Compared with the cumulative average ABI of 1.0–<1.4, multivariable-adjusted HRs for those with a cumulative average ABI of <0.9, 0.9–<1.0 and ≥1.4 were 1.93 (95% CI 1.42–2.61), 1.20 (0.90–1.62) and 1.31 (0.94–1.82), respectively. Conclusions This study indicates both larger decreases and increases in average annual changes in ABI (>0.04/year) were associated with higher mortality risk. Monitoring changes in ABI over time may facilitate risk stratification for mortality among individuals with CKD.

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Migraine as a predictor of mortality: The HUNT study

Cephalalgia ◽

10.1177/0333102415593090 ◽

2015 ◽

Vol 36 (4) ◽

pp. 351-357 ◽

Cited By ~ 9

Author(s):

Anders Nikolai Åsberg ◽

Lars Jacob Stovner ◽

John-Anker Zwart ◽

Bendik Slagsvold Winsvold ◽

Ingrid Heuch ◽

...

Keyword(s):

Cohort Study ◽

Cardiovascular Mortality ◽

Cox Regression ◽

Population Based ◽

Risk Of Death ◽

Hazard Ratios ◽

All Cause Mortality ◽

Large Prospective Cohort Study ◽

Migrainous Headache

Background There is conflicting evidence for the association between migraine and increased mortality risk. The aim of this study was to investigate the relationship between migraine and non-migrainous headache, and all-cause mortality and cardiovascular mortality. Methods In this prospective population-based cohort study from Norway, we used baseline data from the second Nord-Trøndelag Health Survey (HUNT2), performed between 1995 and 1997 in the County of Nord-Trøndelag. These data were linked with a comprehensive mortality database with follow-up through the year 2011. A total of 51,853 (56% of invited) people were categorized based on their answers to the headache questions in HUNT2 (headache free, migraine or non-migrainous headache). Hazard ratios (HRs) of mortality during a mean of 14.1 years of follow-up were estimated using Cox regression. Results During the follow-up period 9408 died, 4321 of these from cardiovascular causes. There was no difference in all-cause mortality between individuals with migraine and non-migrainous headache compared to those without headache or between headache status and mortality by cardiovascular disease. There was, however, among men with migraine without aura a reduced risk of death by cardiovascular diseases (HR 0.72, 95% confidence interval 0.56–0.93). This relationship was not evident in women. Conclusion In this large, prospective cohort study there was no evidence for a higher all-cause mortality or cardiovascular mortality among individuals with migraine.

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The Association of Mediterranean and DASH Diets with Mortality in Adults on Hemodialysis: The DIET-HD Multinational Cohort Study

Journal of the American Society of Nephrology ◽

10.1681/asn.2018010008 ◽

2018 ◽

Vol 29 (6) ◽

pp. 1741-1751 ◽

Cited By ~ 12

Author(s):

Valeria M. Saglimbene ◽

Germaine Wong ◽

Jonathan C. Craig ◽

Marinella Ruospo ◽

Suetonia C. Palmer ◽

...

Keyword(s):

Cohort Study ◽

Cardiovascular Mortality ◽

Cox Regression ◽

Total Mortality ◽

Regression Analyses ◽

Dash Diet ◽

Hazard Ratios ◽

All Cause Mortality ◽

Diet Score

Background Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diets associate with lower cardiovascular and all-cause mortality in the general population, but the benefits for patients on hemodialysis are uncertain.Methods Mediterranean and DASH diet scores were derived from the GA2LEN Food Frequency Questionnaire within the DIET-HD Study, a multinational cohort study of 9757 adults on hemodialysis. We conducted adjusted Cox regression analyses clustered by country to evaluate the association between diet score tertiles and all-cause and cardiovascular mortality (the lowest tertile was the reference category).Results During the median 2.7-year follow-up, 2087 deaths (829 cardiovascular deaths) occurred. The adjusted hazard ratios (95% confidence intervals) for the middle and highest Mediterranean diet score tertiles were 1.20 (1.01 to 1.41) and 1.14 (0.90 to 1.43), respectively, for cardiovascular mortality and 1.10 (0.99 to 1.22) and 1.01 (0.88 to 1.17), respectively, for all-cause mortality. Corresponding estimates for the same DASH diet score tertiles were 1.01 (0.85 to 1.21) and 1.19 (0.99 to 1.43), respectively, for cardiovascular mortality and 1.03 (0.92 to 1.15) and 1.00 (0.89 to 1.12), respectively, for all-cause mortality. The association between DASH diet score and all-cause death was modified by age (P=0.03); adjusted hazard ratios for the middle and highest DASH diet score tertiles were 1.02 (0.81 to 1.29) and 0.70 (0.53 to 0.94), respectively, for younger patients (≤60 years old) and 1.05 (0.93 to 1.19) and 1.08 (0.95 to 1.23), respectively, for older patients.Conclusions Mediterranean and DASH diets did not associate with cardiovascular or total mortality in hemodialysis.

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Abstract MP78: Long-term Antibiotic Use and Risks of All-Cause and Cause-Specific Mortality among Women: Prospective Cohort Study

Circulation ◽

10.1161/circ.137.suppl_1.mp78 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Yoriko Heianza ◽

Wenjie Ma ◽

Yin Cao ◽

Andrew T Chan ◽

Eric B Rimm ◽

...

Keyword(s):

Cohort Study ◽

Cardiovascular Diseases ◽

Cardiovascular Mortality ◽

Prospective Cohort ◽

Antibiotic Use ◽

Antibiotic Exposure ◽

Late Adulthood ◽

All Cause Mortality

Introduction: Antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent major chronic diseases such as cardiovascular diseases and cancer. No previous prospective cohort study has investigated associations between duration of antibiotic use during adulthood with mortality from major chronic diseases among populations at usual risk. Hypothesis: We investigated whether a longer duration of antibiotic use was associated with elevated risks of all-cause and cause-specific deaths among women. Methods: This study included 37,510 women aged ≥60 y who were initially free of cardiovascular diseases or cancer from the Nurses’ Health Study. The present analysis included women who reported data on antibiotic use on the 2004 questionnaire when the information was first assessed. We calculated hazard ratios (HR) for all-cause mortality, and deaths from cardiovascular disease (ICD-8 [international classification of diseases, eighth revision, ICD-8], codes 390 to 458) and cancer (ICD-8, 140-209) according to total days of antibiotic use per year (none, less than 15 days, 15 days to less than 2 months, or ≥2 months) in late adulthood (age 60 or older). Follow-up time was calculated from the return date of the 2004 questionnaire until the date of death, or end of follow-up (June 30, 2012), whichever occurred first. Results: During 287,474 person-years of follow-up, we documented 2908 deaths from any cause (including 474 cardiovascular deaths and 906 cancer deaths). Longer duration of antibiotic use was significantly associated with higher risk of death from any cause after adjusted for dietary intake, lifestyle factors, hypertension, hypercholesterolemia, diabetes ( P trend <0.0001), other medication use (such as aspirin, statin, H2 blockers, proton pump inhibitors) ( P trend =0.001), and other characteristics ( P trend =0.038). As compared to women who did not use antibiotics, those who used for ≥2 months in late adulthood had significantly increased risks of all-cause mortality (multivariate-adjusted HR 1.27; 95% CI, 1.07, 1.49) and cardiovascular mortality (HR 1.58; 95% CI, 1.02, 2.46), but not cancer mortality (HR=0.86; 95% CI, 0.63, 1.16). The association between long-term antibiotic use in late adulthood and an elevated risk of all-cause death was more evident among women who also used antibiotics in middle adulthood (during age 40-59) ( P trend =0.002) than among those who did not use during this life stage. Conclusions: Long-term duration of antibiotic exposure especially in late adulthood was associated with increased all-cause and cardiovascular mortality in women.

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