scholarly journals Real-time simultaneous recording of electrophysiological activities and dopamine overflow in the deep brain nuclei of a non-human primate with Parkinson’s disease using nano-based microelectrode arrays

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Song Zhang ◽  
Yilin Song ◽  
Mixia Wang ◽  
Guihua Xiao ◽  
Fei Gao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Real Time ◽  
Microelectrode Arrays ◽  
Simultaneous Recording ◽  
Brain Nuclei ◽  
Human Primate ◽  
Deep Brain

Complex analysis of neuronal spike trains of deep brain nuclei in patients with Parkinson's disease

2010 ◽  
Vol 81 (6) ◽  
pp. 534-542 ◽  
Author(s):  
Hsiao-Lung Chan ◽  
Ming-An Lin ◽  
Shih-Tseng Lee ◽  
Yu-Tai Tsai ◽  
Pei-Kuang Chao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Complex Analysis ◽  
Spike Trains ◽  
Brain Nuclei ◽  
Neuronal Spike ◽  
Neuronal Spike Trains ◽  
Deep Brain

scholarly journals Controlling pallidal oscillations in real-time in Parkinson's disease using evoked interference deep brain stimulation (eiDBS): proof of concept in the human

2021 ◽  
Author(s):  
David Escobar Sanabria ◽  
Joshua E Aman ◽  
Valentina Zapata Amaya ◽  
Luke A Johnson ◽  
Hafsa Farooqi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Real Time ◽  
Brain Stimulation ◽  
Neural Activity ◽  
Beta Band ◽  
Beta Oscillations ◽  
Oscillatory Dynamics ◽  
Deep Brain

Approaches to control basal ganglia neural activity in real-time are needed to clarify the causal role of 8-35 Hz ("beta band") oscillatory dynamics in the manifestation of Parkinson's disease (PD) motor signs. Here, we show that resonant beta oscillations evoked by electrical stimulation with precise amplitude and timing can be used to predictably suppress or amplify spontaneous beta band activity in the internal segment of the globus pallidus (GPi) in the human. Using this approach, referred to as closed-loop evoked interference deep brain stimulation (eiDBS), we could suppress or amplify frequency-specific (16-22 Hz) neural activity in a PD patient. Amplification of targeted oscillations led to an increase in the variance of motor tracking delays, supporting the hypothesis that pallidal beta oscillations are linked to motor performance. Our results highlight the utility of eiDBS to characterize the pathophysiology of PD and other brain conditions in the human and develop personalized neuromodulation therapies.

Magnetic Resonance Imaging-Directed Method for Functional Neurosurgery Using Implantable Guide Tubes

2007 ◽  
Vol 61 (suppl_5) ◽  
pp. ONS358-ONS366 ◽  
Author(s):  
Nikunj K. Patel ◽  
Puneet Plaha ◽  
Steven S. Gill
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Magnetic Resonance ◽  
General Anesthesia ◽  
Guide Tube ◽  
Resonance Imaging ◽  
Functional Neurosurgery ◽  
Brain Nuclei ◽  
Deep Brain

Abstract Objective: We present a magnetic resonance imaging-directed stereotactic system using implantable guide tubes for targeting deep brain nuclei in functional neurosurgery. Methods: Our method relies on visualization of the deep brain nuclei on high-resolution magnetic resonance images that delineate the target boundaries and enable direct targeting of specific regions of the nucleus. The delivery system comprises a modified stereoguide capable of delivering an implantable guide tube to the vicinity of the desired target. The guide tube (in-house investigational device) has a hub at its proximal end that is fixed within a burr hole and accommodates a radioopaque stylette that is inserted such that its distal end is at the desired target. After perioperative radiological confirmation of the stylette's relationship to the desired brain target, it is withdrawn from the guide tube, which may then act as a port for the implantation of an electrode for deep brain stimulation (DBS) or radiofrequency lesioning. Alternatively, the guide tube can be used to insert a catheter for drug delivery, cell transplantation, or viral-vector delivery. Implantation and verification are guided by magnetic resonance imaging or computed tomography, which enable the entire procedure to be performed under general anesthesia. The technique of implantation helps ensure optimal accuracy, and we have successfully used this device for implanting electrodes for DBS in the treatment of Parkinson's disease, essential tremor, and dystonia, and for implanting catheters for continuous delivery of glial-derived neurotrophic factor in the treatment of Parkinson's disease. The device also aids in securely fixing the DBS electrode or catheter to the cranium with ease, limiting hardware problems. Results: A total of 205 guide tubes have been implanted in 101 patients. Major complications in these cases were limited to 4% of patients. At the initial implantations, 96.3% of the guide tubes were within 1.5 mm of the target. Ten guide tubes required reimplantation secondary to target errors. With corrections, the DBS electrode was delivered to within 1.5 mm from the planned target in all cases. Conclusion: This system provides a safe and accurate magnetic resonance imaging-directed system for targeting deep brain nuclei in functional neurosurgery under general anesthesia and avoids the need for electrophysiological monitoring.

Influence of deep brain stimulation and levodopa on signs and symptoms in Parkinson's disease

2009 ◽  
Vol 36 (S 02) ◽  
Author(s):  
J Gierthmühlen ◽  
P Arning ◽  
G Wasner ◽  
A Binder ◽  
J Herzog ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Signs And Symptoms ◽  
Deep Brain
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