scholarly journals A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders

2017 ◽  
Vol 23 (7) ◽  
pp. 1652-1658 ◽  
Author(s):  
D Mataix-Cols ◽  
E Frans ◽  
A Pérez-Vigil ◽  
R Kuja-Halkola ◽  
C Gromark ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Obsessive Compulsive Disorder ◽  
Total Population ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Multigenerational Family ◽  
Chronic Tic Disorders

Cohort profile: Epidemiology and Genetics of Obsessive–compulsive disorder and chronic tic disorders in Sweden (EGOS)

2020 ◽  
Vol 55 (10) ◽  
pp. 1383-1393 ◽  
Author(s):  
Behrang Mahjani ◽  
Karin Dellenvall ◽  
Anna-Carin Säll Grahnat ◽  
Gun Karlsson ◽  
Aki Tuuliainen ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Chronic Tic Disorders

scholarly journals Evidence-Based Pharmacotherapy for Pediatric Obsessive-Compulsive Disorder and Chronic Tic Disorders

2011 ◽  
Vol 3 ◽  
pp. JCNSD.S6616 ◽  
Author(s):  
Alessandro S. De Nadai ◽  
Eric A. Storch ◽  
Joseph F. Mcguire ◽  
Adam B. Lewin ◽  
Tanya K. Murphy
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Psychosocial Interventions ◽  
Evidence Base ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Behavioral Healthcare ◽  
Pediatric Ocd ◽  
Chronic Tic Disorders

In recent years, much progress has been made in pharmacotherapy for pediatric obsessive-compulsive disorder (OCD) and chronic tic disorders (CTDs). What were previously considered relatively intractable conditions now have an array of efficacious medicinal (and psychosocial) interventions available at clinicians' disposal, including selective serotonin reuptake inhibitors, atypical antipsychotics, and alpha-2 agonists. The purpose of this review is to discuss the evidence base for pharmacotherapy with pediatric OCD and CTDs with regard to efficacy, tolerability, and safety, and to put this evidence in the context of clinical management in integrated behavioral healthcare. While there is no single panacea for these disorders, there are a variety of medications that provide considerable relief for children with these disabling conditions.

scholarly journals Cross-disorder comparison of sensory over-responsivity in chronic tic disorders and obsessive-compulsive disorder

2021 ◽  
pp. 152291
Author(s):  
David Isaacs ◽  
Alexandra P. Key ◽  
Carissa J. Cascio ◽  
Alexander C. Conley ◽  
Heather Riordan ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Chronic Tic Disorders

Bipolar disorder and comorbid obsessive-compulsive disorder is associated with higher rates of anxiety and impulse control disorders

2010 ◽  
Vol 22 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Cilly Klüger Issler ◽  
Emel Serap Monkul ◽  
José Antonio de Mello Siqueira Amaral ◽  
Renata Sayuri Tamada ◽  
Roseli Gedanke Shavitt ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Obsessive Compulsive Disorder ◽  
Impulse Control ◽  
Severe Form ◽  
Impulse Control Disorders ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Residual Symptoms ◽  
Compulsive Disorder ◽  
Depressive Episodes

Issler CK, Monkul ES, Amaral JAMS, Tamada RS, Shavitt RG, Miguel EC, Lafer B. Bipolar disorder and comorbid obsessive-compulsive disorder is associated with higher rates of anxiety and impulse control disorders.Objective:Although bipolar disorder (BD) with comorbid obsessive-compulsive disorder (OCD) is highly prevalent, few controlled studies have assessed this comorbidity. The objective of this study was to investigate the clinical characteristics and expression of comorbid disorders in female BD patients with OCD.Method:We assessed clinically stable female outpatients with BD: 15 with comorbid OCD (BD+OCD group) and 15 without (BD/no-OCD group). All were submitted to the Structured Clinical Interview for DSM-IV, with additional modules for the diagnosis of kleptomania, trichotillomania, pathological gambling, onychophagia and skin picking.Results:The BD+OCD patients presented more chronic episodes, residual symptoms and previous depressive episodes than the BD/no-OCD patients. Of the BD+OCD patients, 86% had a history of treatment-emergent mania, compared with only 40% of the BD/no-OCD patients. The following were more prevalent in the BD+OCD patients than the BD/no-OCD patients: any anxiety disorder other than OCD; impulse control disorders; eating disorders; and tic disorders.Conclusion:Female BD patients with OCD may represent a more severe form of disorder than those without OCD, having more depressive episodes and residual symptoms, and being at a higher risk for treatment-emergent mania, as well as presenting a greater anxiety and impulse control disorder burden.

scholarly journals Inflammation in Tic Disorders and Obsessive-Compulsive Disorder: Are PANS and PANDAS a Path Forward?

2019 ◽  
Vol 34 (10) ◽  
pp. 598-611 ◽  
Author(s):  
Donald L. Gilbert
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Tic Disorders ◽  
Published Data ◽  
Clinical Practices ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Scientific Questions

This review and commentary is the product of an invited lecture called “Autoimmunity: PANS/PANDAS” presented at the 2018 Neurobiology of Diseases in Children Symposium in Chicago, IL. The talk addressed clinical and scientific questions and recently published data. At this time, among highly experienced and respected clinicians and researchers spanning relevant disciplines, there is substantial controversy regarding a role for inflammation in producing tics and obsessive-compulsive disorder. This commentary summarizes these controversies, discusses reasons for opposing views on best clinical practices, and concludes with suggestions for pathways forward.

scholarly journals Comorbidity in Juvenile Obsessive—Compulsive Disorder: A Report from India

2000 ◽  
Vol 45 (3) ◽  
pp. 274-278 ◽  
Author(s):  
YC Janardhan Reddy ◽  
P Srinivas Reddy ◽  
S Srinath ◽  
S Khanna ◽  
SP Sheshadri ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Children And Adolescents ◽  
Obsessive Compulsive Disorder ◽  
Structured Interview ◽  
Child And Adolescent Psychiatry ◽  
Tic Disorders ◽  
Obsessive Compulsive ◽  
Interview Schedule ◽  
Compulsive Disorder ◽  
Disruptive Disorders

Objective: Using minimal exclusion criteria, to assess systematically the psychiatric comorbidity in children and adolescents with obsessive–compulsive disorder (OCD) and compare the findings with those of previous studies. Method: Fifty-four children and adolescents who satisfied DSM-III-R criteria for OCD were assessed using a structured interview schedule, the Children's version of the Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and the questionnaire for tic disorders. All 54 subjects were recruited from the Child and Adolescent Psychiatry (CAP) services of the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, South India. Diagnoses were determined consensually after a review of all the available data. Results: Comorbidity was found in 69% of the sample: 22% were diagnosed with disruptive disorders; 20% met criteria for mood disorders; 19% had anxiety disorders; and 17% had tic disorders. Only 1 subject had bipolar disorder, and none had psychosis. The rates for individual diagnoses—in particular, the rates for disruptive disorders, bipolar disorder, and psychosis—were considerably lower than those reported in previous studies. Conclusions: Patterns of comorbidity in this study differed from those previously reported. Novel patterns of comorbidity with disruptive disorders, bipolar disorder, and psychosis reported in a few recent studies were not replicated in this study. These differences are probably due to different ascertainment methods. Comorbidity needs to be assessed in large epidemiological samples before definite associations can be made between certain comorbid disorders and juvenile OCD.

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