Luteinizing hormone receptor

2007 ◽  
Author(s):  
Thomas Buech ◽  
Pascal Nurwakagari ◽  
David Ben-Menahem ◽  
Thomas Gudermann
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor

Role of luteinizing hormone receptor in the ontogeny and progression of adrenocortical tumors in transgenic mice expressing SV40Tag under the inhibin-[alpha] promoter

2016 ◽  
Author(s):  
Milena Doroszko ◽  
Marcin Chrusciel ◽  
Kirstine Belling ◽  
Susanna Vuorenoja ◽  
Marlene Dalgaard ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Transgenic Mice ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Adrenocortical Tumors

Depletion of the primate-specific luteinizing-hormone receptor splice variant 'exon-6A' impairs LH-, but not hCG-mediated signaling in human primary granulosa cells

2018 ◽  
Author(s):  
Livio Casarini ◽  
Laura Riccetti ◽  
Samantha Sperduti ◽  
Clara Lazzaretti ◽  
Alessia Masini ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Granulosa Cells ◽  
Hormone Receptor ◽  
Splice Variant ◽  
Luteinizing Hormone Receptor ◽  
Variant Exon

scholarly journals Possible Relevance of Soluble Luteinizing Hormone Receptor during Development and Adulthood in Boys and Men

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1329
Author(s):  
Li Juel Mortensen ◽  
Mette Lorenzen ◽  
Anne Jørgensen ◽  
Jakob Albrethsen ◽  
Niels Jørgensen ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Adrenal Glands ◽  
Seminal Fluid ◽  
Body Fluids ◽  
Luteinizing Hormone Receptor ◽  
Gonadal Function ◽  
Fetal Kidney ◽  
Healthy Men ◽  
Human Fetal Kidney

Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are agonists for the luteinizing hormone receptor (LHCGR) which regulates male reproductive function. LHCGR may be released into body fluids. We wish to determine whether soluble LHCGR is a marker for gonadal function. Cross-sectional, longitudinal, and intervention studies on 195 healthy boys and men and 396 men with infertility, anorchia, or Klinefelter Syndrome (KS) were used to correlate LHCGR measured in serum, seminal fluid, urine, and hepatic/renal artery and vein with gonadal function. LHCGR was determined in fluids from in vitro and in vivo models of human testicular tissue and cell lines, xenograft mouse models, and human fetal kidney and adrenal glands. Western blot showed LHCGR fragments in serum and gonadal tissue of similar size using three different antibodies. The LHCGR-ELISA had no species cross-reactivity or unspecific reaction in mouse serum even after human xenografting. Instead, sLHCGR was released into the media after the culture of a human fetal kidney and adrenal glands. Serum sLHCGR decreased markedly during puberty in healthy boys (p = 0.0001). In healthy men, serum sLHCGR was inversely associated with the Inhibin B/FSH ratio (β −0.004, p = 0.027). In infertile men, seminal fluid sLHCGR was inversely associated with serum FSH (β 0.006, p = 0.009), sperm concentration (β −3.5, p = 0.003) and total sperm count (β −3.2, p = 0.007). The injection of hCG lowered sLHCGR in serum and urine of healthy men (p < 0.01). In conclusion, sLHCGR is released into body-fluids and linked with pubertal development and gonadal function. Circulating sLHCGR in anorchid men suggests that sLHCGR in serum may originate from and possibly exert actions in non-gonadal tissues. (ClinicalTrials: NTC01411527, NCT01304927, NCT03418896).

scholarly journals Glucose-Regulated Protein, 78-Kilodalton Is a Modulator of Luteinizing Hormone Receptor Expression in Luteinizing Granulosa Cells in Rats1

2013 ◽  
Vol 88 (1) ◽  
Author(s):  
Kayoko Kogure ◽  
Kazuto Nakamura ◽  
Sadatomo Ikeda ◽  
Yoshikazu Kitahara ◽  
Toshio Nishimura ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Granulosa Cells ◽  
Hormone Receptor ◽  
Receptor Expression ◽  
Luteinizing Hormone Receptor ◽  
Hormone Receptor Expression ◽  
Glucose Regulated Protein

scholarly journals [3H]Org 43553, the First Low-Molecular-Weight Agonistic and Allosteric Radioligand for the Human Luteinizing Hormone Receptor

2007 ◽  
Vol 73 (2) ◽  
pp. 518-524 ◽  
Author(s):  
Laura H. Heitman ◽  
Julia Oosterom ◽  
Kimberly M. Bonger ◽  
Cornelis M. Timmers ◽  
Peter H. G. Wiegerinck ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Low Molecular Weight

scholarly journals Compound heterozygous mutations of the luteinizing hormone receptor gene in Leydig cell hypoplasia.

1996 ◽  
Vol 10 (8) ◽  
pp. 987-997
Author(s):  
L L Laue ◽  
S M Wu ◽  
M Kudo ◽  
C J Bourdony ◽  
G B Cutler ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Leydig Cell ◽  
Hormone Receptor ◽  
Receptor Gene ◽  
Luteinizing Hormone Receptor ◽  
Compound Heterozygous ◽  
Compound Heterozygous Mutations ◽  
Leydig Cell Hypoplasia ◽  
Hormone Receptor Gene

Localization of Luteinizing Hormone Receptor Messenger Ribonucleic Acid Expression in Ovarian Cell Types during Follicle Development and Ovulation*

Endocrinology ◽  
1991 ◽  
Vol 129 (6) ◽  
pp. 3200-3207 ◽  
Author(s):  
XIAO-RONG PENG ◽  
AARON J. W. HSUEH ◽  
PHILIP S. LAPOLT ◽  
LARS BJERSING ◽  
T. NY
Keyword(s):  
Luteinizing Hormone ◽  
Ribonucleic Acid ◽  
Hormone Receptor ◽  
Cell Types ◽  
Luteinizing Hormone Receptor ◽  
Follicle Development ◽  
Ovarian Cell ◽  
Messenger Ribonucleic Acid
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