Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

Nature ◽  
2008 ◽  
Vol 453 (7197) ◽  
pp. 940-943 ◽  
Author(s):  
Ferdia A. Gallagher ◽  
Mikko I. Kettunen ◽  
Sam E. Day ◽  
De-En Hu ◽  
Jan Henrik Ardenkjær-Larsen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Hyperpolarized 13C

scholarly journals Metabolic Imaging by Hyperpolarized 13C Magnetic Resonance Imaging for In vivo Tumor Diagnosis

2006 ◽  
Vol 66 (22) ◽  
pp. 10855-10860 ◽  
Author(s):  
Klaes Golman ◽  
René in't Zandt ◽  
Mathilde Lerche ◽  
Rikard Pehrson ◽  
Jan Henrik Ardenkjaer-Larsen
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Tumor Diagnosis ◽  
Metabolic Imaging ◽  
Resonance Imaging ◽  
Hyperpolarized 13C

scholarly journals Monitoring urea transport in rat kidney in vivo using hyperpolarized 13C magnetic resonance imaging

2012 ◽  
Vol 302 (12) ◽  
pp. F1658-F1662 ◽  
Author(s):  
Cornelius von Morze ◽  
Robert A. Bok ◽  
Jeff M. Sands ◽  
John Kurhanewicz ◽  
Daniel B. Vigneron
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nuclear Polarization ◽  
Collecting Duct ◽  
Rat Kidney ◽  
Resonance Imaging ◽  
Hyperpolarized 13C ◽  
New Methods ◽  
Medullary Collecting Duct

Urea functions as a key osmolyte in the urinary concentrating mechanism of the inner medulla. The urea transporter UT-A1 is upregulated by antidiuretic hormone, facilitating faster equilibration of urea between the lumen and interstitium of the inner medullary collecting duct, resulting in the formation of more highly concentrated urine. New methods in dynamic nuclear polarization, providing ∼50,000-fold enhancement of nuclear magnetic resonance signals in the liquid state, offer a novel means to monitor this process in vivo using magnetic resonance imaging. In this study, we detected significant signal differences in the rat kidney between acute diuretic and antidiuretic states, using dynamic 13C magnetic resonance imaging following a bolus infusion of hyperpolarized [13C]urea. More rapid medullary enhancement was observed under antidiuresis, consistent with known upregulation of UT-A1.

Monitoring stem cell migration in the nervous system by in vivo magnetic resonance imaging

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S692-S692
Author(s):  
Mathias Hoehn ◽  
Uwe Himmelreich ◽  
Ralph Weber ◽  
Pedro Ramos-Cabrer ◽  
Susanne Wegener ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nervous System ◽  
Stem Cell ◽  
Cell Migration ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Stem Cell Migration

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

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