Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus

2008 ◽  
Vol 4 (7) ◽  
pp. 352-353 ◽  
Author(s):  
Hai Feng Pan ◽  
Dong Qing Ye ◽  
Xiang Pei Li
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Therapeutic Target ◽  
T Helper Cells ◽  
T Helper ◽  
Systemic Lupus ◽  
Helper Cells ◽  
Promising Therapeutic Target

scholarly journals Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

1999 ◽  
Vol 42 (8) ◽  
pp. 1644-1648 ◽  
Author(s):  
Mitsuteru Akahoshi ◽  
Hitoshi Nakashima ◽  
Yosuke Tanaka ◽  
Tsutomu Kohsaka ◽  
Shuji Nagano ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
T Helper Cells ◽  
T Helper ◽  
Systemic Lupus ◽  
Helper Cells

scholarly journals Current Insights and Future Prospects for Targeting IL-17 to Treat Patients With Systemic Lupus Erythematosus

2021 ◽  
Vol 11 ◽  
Author(s):  
Tomohiro Koga ◽  
Kunihiro Ichinose ◽  
Atsushi Kawakami ◽  
George C. Tsokos
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Therapeutic Target ◽  
Molecular Mechanisms ◽  
Immune Cell ◽  
Ex Vivo ◽  
Systemic Lupus ◽  
Promising Therapeutic Target ◽  
Attractive Therapeutic Target ◽  
And Function

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immune cell abnormalities which lead to the production of autoantibodies and the deposition of immune complexes. Interleukin (IL)-17-producing cells play an important role in the pathogenesis of the disease, making them an attractive therapeutic target. Studies in lupus-prone mice and of ex vivo cells from patients with SLE humans have shown that IL-17 represents a promising therapeutic target. Here we review molecular mechanisms involved in IL-17 production and Th17 cell differentiation and function and an update on the role of IL-17 in autoimmune diseases and the expected usefulness for targeting IL-17 therapeutically.

Type 17 T-helper cells might be a promising therapeutic target for osteoporosis

2011 ◽  
Vol 39 (1) ◽  
pp. 771-774 ◽  
Author(s):  
Feng-Lai Yuan ◽  
Xia Li ◽  
Wei-Guo Lu ◽  
Yi-Qing Zhao ◽  
Cheng-Wan Li ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
T Helper Cells ◽  
T Helper ◽  
Helper Cells ◽  
Promising Therapeutic Target

IL-23: A Promising Therapeutic Target for Systemic Lupus Erythematosus

2010 ◽  
Vol 41 (3) ◽  
pp. 221-225 ◽  
Author(s):  
Rui-Xue Leng ◽  
Hai-Feng Pan ◽  
Gui-Mei Chen ◽  
Chao Wang ◽  
Wei-Zi Qin ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Therapeutic Target ◽  
Systemic Lupus ◽  
Promising Therapeutic Target

scholarly journals The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus

Rheumatology ◽  
2009 ◽  
Vol 48 (12) ◽  
pp. 1491-1497 ◽  
Author(s):  
B. C.-H. Kwan ◽  
L.-S. Tam ◽  
K.-B. Lai ◽  
F. M.-M. Lai ◽  
E. K.-M. Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Systemic Lupus ◽  
Urinary Sediment
Sign in / Sign up

Export Citation Format

Share Document