scholarly journals Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

2009 ◽  
Vol 41 (5) ◽  
pp. 524-526 ◽  
Author(s):  
Jennifer C King ◽  
Jin Xu ◽  
John Wongvipat ◽  
Haley Hieronymus ◽  
Brett S Carver ◽  
...  
Keyword(s):  
Pi3 Kinase ◽  
Pathway Activation ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals CSIG-34. PI3 KINASE PATHWAY ACTIVATION PROMOTES MALIGNANT PROGRESSION IN OLIGODENDROGLIAL TUMORS

2018 ◽  
Vol 20 (suppl_6) ◽  
pp. vi50-vi50
Author(s):  
Kensuke Tateishi ◽  
Taishi Nakamura ◽  
Alexandria Fink ◽  
Nina Lelic ◽  
Yuko Matsushita ◽  
...  
Keyword(s):  
Pi3 Kinase ◽  
Malignant Progression ◽  
Oligodendroglial Tumors ◽  
Pathway Activation ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

Integration of stimulatory and inhibitory signals in pituitary tumor cells through the PI3 kinase pathway

2006 ◽  
Vol 114 (08) ◽  
Author(s):  
T Colaco ◽  
C Onofri ◽  
M Theodoropoulou ◽  
M Kowarik ◽  
GK Stalla ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Pituitary Tumor ◽  
Pi3 Kinase ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

Integrin α8β1–fibronectin interactions promote cell survival via PI3 kinase pathway

2005 ◽  
Vol 329 (1) ◽  
pp. 305-311 ◽  
Author(s):  
Eduardo Farias ◽  
Min Lu ◽  
Xianwu Li ◽  
Lynn M. Schnapp
Keyword(s):  
Cell Survival ◽  
Pi3 Kinase ◽  
Promote Cell Survival ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals c-Cbl Is Tyrosine-Phosphorylated by Interleukin-4 and Enhances Mitogenic and Survival Signals of Interleukin-4 Receptor by Linking With the Phosphatidylinositol 3′-Kinase Pathway

Blood ◽  
1998 ◽  
Vol 91 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Hiroo Ueno ◽  
Ko Sasaki ◽  
Hiroaki Honda ◽  
Tetsuya Nakamoto ◽  
Tetsuya Yamagata ◽  
...  
Keyword(s):  
Specific Inhibitor ◽  
Pi3 Kinase ◽  
Interleukin 4 ◽  
Phosphatidylinositol 3 Kinase ◽  
Proliferation And Differentiation ◽  
Interleukin 4 Receptor ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway ◽  
Phosphatidylinositol 3 ◽  
Survival Signals

Interleukin-4 (IL-4) is a cytokine that induces both proliferation and differentiation and suppresses apoptosis of B cells. Although IL-4 has been shown to activate the phosphatidylinositol 3′ (PI3)-kinase pathway, the role of PI3 kinase in the IL-4 receptor (IL-4R) signaling remains unclear. In this study, we demonstrated that c-Cbl proto-oncogene product is inducibly phosphorylated on tyrosine residues and is associated with the p85 subunit of PI3-kinase by IL-4 stimulation. Overexpression of c-Cbl enhances the PI3-kinase activity and, at the same time, mitogenic activity and survival of cells in the presence of IL-4. However, these effects of c-Cbl were abolished by wortmannin, a specific inhibitor for the PI3 kinase pathway, or by a point mutation at tyrosine 731 of c-Cbl, which is a major binding site for p85. These results indicate that c-Cbl plays a role in linking IL-4R with the PI3 kinase pathway and thus enhancing the mitogenic and survival signals.

scholarly journals PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Rajani Kanteti ◽  
Jacob J. Riehm ◽  
Immanuel Dhanasingh ◽  
Frances E. Lennon ◽  
Tamara Mirzapoiazova ◽  
...  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Pi3 Kinase ◽  
Pleural Mesothelioma ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

scholarly journals PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA

2016 ◽  
Vol 15 (1) ◽  
Author(s):  
Zahid Nawaz ◽  
Vikas Patil ◽  
Yashna Paul ◽  
Alangar S. Hegde ◽  
Arimappamagan Arivazhagan ◽  
...  
Keyword(s):  
Pi3 Kinase ◽  
Tumour Suppressor ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway

Tonic support of contraction involving the PI3 kinase pathway in ventricular myocytes from failing human heart

2008 ◽  
Vol 44 (4) ◽  
pp. 752-753
Author(s):  
Edwin A. Garcia ◽  
Gaelle Kikonda Kanda ◽  
Alexander Lyon ◽  
Clare E. Gallon ◽  
Andrew E. Messer ◽  
...  
Keyword(s):  
Human Heart ◽  
Ventricular Myocytes ◽  
Pi3 Kinase ◽  
Pi3 Kinase Pathway ◽  
Kinase Pathway
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