scholarly journals Covariate selection for association screening in multiphenotype genetic studies

2017 ◽  
Vol 49 (12) ◽  
pp. 1789-1795 ◽  
Author(s):  
Hugues Aschard ◽  
Vincent Guillemot ◽  
Bjarni Vilhjalmsson ◽  
Chirag J Patel ◽  
David Skurnik ◽  
...  
Keyword(s):  
Genetic Studies ◽  
Covariate Selection ◽  
Selection For

scholarly journals A review of covariate selection for non-experimental comparative effectiveness research

2013 ◽  
Vol 22 (11) ◽  
pp. 1139-1145 ◽  
Author(s):  
Brian C. Sauer ◽  
M. Alan Brookhart ◽  
Jason Roy ◽  
Tyler VanderWeele
Keyword(s):  
Comparative Effectiveness Research ◽  
Comparative Effectiveness ◽  
Effectiveness Research ◽  
Covariate Selection ◽  
Selection For

Genetic studies of South Australian Merino sheep. 4. Genetic, phenotypic and environmental correlations between various wool and body traits

1982 ◽  
Vol 33 (2) ◽  
pp. 363 ◽  
Author(s):  
IP Gregory
Keyword(s):  
Great Increase ◽  
Fibre Diameter ◽  
Skin Thickness ◽  
Primary Follicle ◽  
Genetic Studies ◽  
Environmental Correlations ◽  
Merino Sheep ◽  
Selection For ◽  
Fleece Weight ◽  
Australian Merino

Genetic, phenotypic and environmental correlations were estimated between 23 quantitative and qualitative wool and body traits of South Australian Merino sheep. Clean fleece weight was significantly correlated genetically with greasy fleece weight (0.62), yield (0.47), staple length (0.41), crimps per inch (-0.34), secondary/primary follicle ratio (0.37) and skin thickness (0.39). No significant half-sib genetic correlation was found between clean fleece weight and fibre diameter and the dam-offspring correlation was quite low, although significant (0.16, P < 0.05). This indicates that selection for clean fleece weight should not lead to any great increase in fibre diameter. Skin thickness is discussed as a possible early indicator of clean fleece weight.

scholarly journals An Improved Cloning Vector for Construction of Gene Replacements in Listeria monocytogenes

2003 ◽  
Vol 69 (5) ◽  
pp. 3020-3023 ◽  
Author(s):  
Guojie Li ◽  
S. Kathariou
Keyword(s):  
Escherichia Coli ◽  
Listeria Monocytogenes ◽  
Plasmid Vector ◽  
Gene Replacement ◽  
Direct Selection ◽  
Genetic Studies ◽  
Food Borne ◽  
Food Borne Illness ◽  
Selection For ◽  
Selection Of

ABSTRACT Listeria monocytogenes is a gram-positive, facultative intracellular bacterium implicated in severe food-borne illness (listeriosis) in humans. The construction of well-defined gene replacements in the genome of L. monocytogenes has been instrumental to several genetic studies of the virulence and other attributes of the organism. Construction of such mutations by currently available procedures, however, tends to be labor intensive, and gene replacement mutants are sometimes difficult to recover due to lack of direct selection for the construct. In this study we describe the construction and use of plasmid vector pGF-EM, which can be conjugatively transferred from Escherichia coli S17-1 to L. monocytogenes and which provides the genetic means for direct selection of gene replacements.

GENETIC STUDIES ON WALKING BEHAVIOR IN DROSOPHILA MELANOGASTER I. SELECTION AND HYBRIDIZATION ANALYSIS

1975 ◽  
Vol 17 (4) ◽  
pp. 535-542 ◽  
Author(s):  
Jong-Kil Choo
Keyword(s):  
Drosophila Melanogaster ◽  
Major Gene ◽  
Test Tube ◽  
Hybridization Analysis ◽  
Slow Response ◽  
Genetic Studies ◽  
Walking Behavior ◽  
Selection For

Rapid vs. slow types of walking behavior in Drosophila melanogaster were tested in response to light in a connected test-tube apparatus. The effect of selection for both types of behavior was clearly recognized after only a few generations. The heritability of the two traits of walking behavior was remarkably different; the former was estimated to be about 7%, the latter 26%. Walking behavior is possibly controlled by a major gene with the behaviour manifesting slow response to light being dominant to that manifesting rapid walking behavior.

scholarly journals Covariate Selection for Mortgage Default Analysis Using Survival Models

2021 ◽  
Vol 11 (02) ◽  
pp. 218-233
Author(s):  
Dongfang Zhang ◽  
Basu Bhandari ◽  
Dennis Black
Keyword(s):  
Survival Models ◽  
Mortgage Default ◽  
Covariate Selection ◽  
Selection For

Six years of selection responses for resistance or susceptibility to ryegrass staggers in sheep

1999 ◽  
Vol 7 ◽  
pp. 27-31
Author(s):  
C.A. Morris ◽  
N.R. Towers ◽  
N.C. Amyes
Keyword(s):  
Genetic Parameters ◽  
Phase 1 ◽  
Breeding Value ◽  
Selection Line ◽  
Phase 2 ◽  
Genetic Studies ◽  
Lolium Perenne L ◽  
Susceptible Line ◽  
Ewe Lambs ◽  
Selection For

Ryegrass staggers (RGS) is a neurotoxic disease in ruminants. It is caused by the mycotoxin lolitrem B, found in endophyte-infected perennial ryegrass (Lolium perenne L.). This paper reviews genetic studies on the resistance of sheep to RGS at Ruakura. Genetic differences in susceptibility among sire groups were evaluated in lambs born in 1988-92 (Phase 1). Selection lines were then formed and responses to selection for resistance or susceptibility are described for the 1993-98 birth years (Phase 2). The incidence of RGS was recorded on a presence or absence basis from January to March or April each year, in experimental flocks with animals of known pedigree. For estimating genetic parameters (Phase 1), there were 3587 RGS records available from 2307 animals representing 232 sires. Clinical cases of RGS occurred in 17 of 25 contemporary groups, with incidences per group up to 16%. Estimates of heritability and acrossyear repeatability for RGS incidence were 0.068 ± 0.028 and 0.24 ± 0.05 respectively. Breeding value data were used at the beginning of Phase 2 to screen ewes, two-tooths and ewe lambs into resistant and susceptible selection flocks (lines). Breeding values were also used to select rams that were elite for RGS, and to allocate these to each line for mating. At least some natural RGS challenge was experienced by the resulting selection-line stock born in five of the six years of Phase 2. Susceptible-line lambs had a mean incidence of 39% clinical RGS cases over these five years, whilst the resistant-line lambs grazing the same paddocks had a much lower mean clinical RGS incidence (P

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