scholarly journals Too Much of a Good Thing: Blocking Noradrenergic Facilitation in Medial Prefrontal Cortex Prevents the Detrimental Effects of Chronic Stress on Cognition

2012 ◽  
Vol 38 (4) ◽  
pp. 585-595 ◽  
Author(s):  
Julianne D Jett ◽  
David A Morilak
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Good Thing

The effect of citalopram on chronic stress-induced depressive-like behavior in rats through GSK3β/β-catenin activation in the medial prefrontal cortex

2012 ◽  
Vol 88 (4) ◽  
pp. 338-344 ◽  
Author(s):  
Y.C. Chen ◽  
Q.R. Tan ◽  
W. Dang ◽  
H.N. Wang ◽  
R.B. Zhang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex

scholarly journals Molecular mechanism of reward treatment ameliorating chronic stress-induced depressive-like behavior assessed by sequencing miRNA and mRNA in medial prefrontal cortex

2020 ◽  
Author(s):  
Tingting An ◽  
Zhenhua Song ◽  
Jin-Hui Wang
Keyword(s):  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Molecular Mechanism ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Differentially Expressed ◽  
Mild Stress ◽  
Major Depressive ◽  
Differentially Expressed Mirnas

Abstract Background Major depressive disorder (MDD) is a disease that seriously endangers human health and mental state. Chronic stress and lack of reward may reduce the function of the brain's reward circuits, leading to major depressive disorder. The effect of reward treatment on chronic stress-induced depression-like behaviors and its molecular mechanism in the brain remain unclear.Methods Mice were divided into the groups of control, chronic unpredictable mild stress (CUMS), and CUMS-companion. Mice of CUMS group was performed by CUMS for 4 weeks, and CUMS-companion group was treated by CUMS accompanied with companion. The tests of sucrose preference, Y-maze, and forced swimming were conducted to assess depression-like behaviors or resilience. High-throughput sequencing was used to analyze mRNA and miRNA profiles in the medial prefrontal cortex harvested from control, CUMS-MDD (mice with depression-like behaviors in CUMS group), Reward-MDD (mice with depression-like behaviors in CUMS-companion group), CUMS-resilience (resilient mice in CUMS group), Reward-resilience (resilient mice in CUMS-companion group) mice.Results The results provided evidence that accompanying with companion ameliorated CUMS-induced depression-like behaviors in mice. 45 differentially expressed genes (DEGs) are associated with depression-like behaviors, 8 DEGs are associated with resilience and 59 DEGs are associated with nature reward (companion) were identified. Furthermore, 196 differentially expressed miRNAs were found to be associated with companion. Based on the differentially expressed miRNAs and DEGs data, miRNA-mRNA network was established to be associated with companion.Conclusion Taken together, our data here provided a method to ameliorate depression-like behaviors, and numerous potential drug targets for the prevention or treatment of depression.

scholarly journals Chronic stress alters neural activity in medial prefrontal cortex during retrieval of extinction

Neuroscience ◽  
2011 ◽  
Vol 174 ◽  
pp. 115-131 ◽  
Author(s):  
A.A. Wilber ◽  
A.G. Walker ◽  
C.J. Southwood ◽  
M.R. Farrell ◽  
G.L. Lin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Neural Activity

Sensitization of norepinephrine release in medial prefrontal cortex: effect of different chronic stress protocols

1999 ◽  
Vol 830 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Hank P. Jedema ◽  
Alan F. Sved ◽  
Michael J. Zigmond ◽  
Janet M. Finlay
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Norepinephrine Release

Chronic stress alters inhibitory networks in the medial prefrontal cortex of adult mice

2012 ◽  
Vol 218 (6) ◽  
pp. 1591-1605 ◽  
Author(s):  
Javier Gilabert-Juan ◽  
Esther Castillo-Gomez ◽  
Ramón Guirado ◽  
Maria Dolores Moltó ◽  
Juan Nacher
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Adult Mice ◽  
Inhibitory Networks

Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making

Science ◽  
2009 ◽  
Vol 325 (5940) ◽  
pp. 621-625 ◽  
Author(s):  
Eduardo Dias-Ferreira ◽  
João C. Sousa ◽  
Irene Melo ◽  
Pedro Morgado ◽  
Ana R. Mesquita ◽  
...  
Keyword(s):  
Decision Making ◽  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Structural Changes ◽  
Relative Advantage ◽  
Behavioral Strategies ◽  
Making Choices ◽  
Corticostriatal Circuits

The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.

Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: Does hemisphere location matter?

2008 ◽  
Vol 190 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Boldizsár Czéh ◽  
Claudia Perez-Cruz ◽  
Eberhard Fuchs ◽  
Gabriele Flügge
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex ◽  
Clinical Implications ◽  
Cellular Changes

Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex

Neuroscience ◽  
2011 ◽  
Vol 183 ◽  
pp. 108-120 ◽  
Author(s):  
Y.A. Lee ◽  
P. Poirier ◽  
S. Otani ◽  
Y. Goto
Keyword(s):  
Prefrontal Cortex ◽  
Chronic Stress ◽  
Medial Prefrontal Cortex
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