scholarly journals Spatial regulation of gene expression during growth of articular cartilage in juvenile mice

2014 ◽  
Vol 77 (3) ◽  
pp. 406-415 ◽  
Author(s):  
Julian C. Lui ◽  
Michael Chau ◽  
Weiping Chen ◽  
Crystal S. F. Cheung ◽  
Jeffrey Hanson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Articular Cartilage ◽  
Regulation Of Gene Expression ◽  
Spatial Regulation

scholarly journals A transcriptomic taxonomy of Drosophila circadian neurons around the clock

2020 ◽  
Author(s):  
Dingbang Ma ◽  
Dariusz Przybylski ◽  
Katharine C. Abruzzi ◽  
Matthias Schlichting ◽  
Qunlong Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synapse Formation ◽  
Regulation Of Gene Expression ◽  
Surface Proteins ◽  
Circadian Oscillation ◽  
Temporal Regulation ◽  
Functional Studies ◽  
Spatial Regulation ◽  
Sequencing Method ◽  
The Many

AbstractMany different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we optimized a single cell RNA sequencing method and assayed clock neuron gene expression at different times of day. The data identify at least 17 clock neuron categories with striking spatial regulation of gene expression. Transcription factor regulation is prominent and likely contributes to the robust circadian oscillation of many transcripts, including those that encode cell-surface proteins previously shown to be important for cell recognition and synapse formation during development. We suggest that these molecules orchestrate the temporal regulation of synapse formation and/or strength. The many other clock-regulated genes also constitute an important resource for future mechanistic and functional studies between clock neurons and/or for temporal signaling to circuits elsewhere in the fly brain.

Regulatory noncoding RNAs at Hox lociThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

2009 ◽  
Vol 87 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Hugh W. Brock ◽  
Jacob W. Hodgson ◽  
Svetlana Petruk ◽  
Alexander Mazo
Keyword(s):  
Gene Expression ◽  
Hox Genes ◽  
Peer Review Process ◽  
Regulation Of Gene Expression ◽  
Chromatin Dynamics ◽  
Spatial Regulation ◽  
Positional Identity ◽  
In Trans ◽  
In Cis

There is growing awareness of the importance of noncoding (nc)RNAs in the regulation of gene expression during pattern formation in development. Spatial regulation of Hox gene expression in development controls positional identity along the antero–posterior axis. In this review, we will focus on the role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long ncRNAs that may repress a Hox in cis in Drosophila by transcriptional interference, and on a novel long ncRNA that functions in trans to regulate Hox genes mammals.

scholarly journals A transcriptomic taxonomy of Drosophila circadian neurons around the clock

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Dingbang Ma ◽  
Dariusz Przybylski ◽  
Katharine C Abruzzi ◽  
Matthias Schlichting ◽  
Qunlong Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Synapse Formation ◽  
Regulation Of Gene Expression ◽  
Surface Proteins ◽  
Circadian Oscillation ◽  
Functional Studies ◽  
Spatial Regulation ◽  
Sequencing Method ◽  
Transcription Factor Regulation ◽  
The Many

Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we optimized a single-cell RNA sequencing method and assayed clock neuron gene expression at different times of day. The data identify at least 17 clock neuron categories with striking spatial regulation of gene expression. Transcription factor regulation is prominent and likely contributes to the robust circadian oscillation of many transcripts, including those that encode cell-surface proteins previously shown to be important for cell recognition and synapse formation during development. The many other clock-regulated genes also constitute an important resource for future mechanistic and functional studies between clock neurons and/or for temporal signaling to circuits elsewhere in the fly brain.

scholarly journals Turning on Myogenin in Muscle: A Paradigm for Understanding Mechanisms of Tissue-Specific Gene Expression

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Herve Faralli ◽  
F. Jeffrey Dilworth
Keyword(s):  
Gene Expression ◽  
Developmental Regulation ◽  
Regulation Of Gene Expression ◽  
Specific Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Spatial Regulation ◽  
Dna Elements ◽  
Temporal And Spatial ◽  
Expression Program

Expression of themyogenin(Myog) gene is restricted to skeletal muscle cells where the transcriptional activator turns on a gene expression program that permits the transition from proliferating myoblasts to differentiating myotubes. The strict temporal and spatial regulation onMyogexpression in the embryo makes it an ideal gene to study the developmental regulation of tissue-specific expression. Over the last 20 years, our knowledge of the regulation ofMyogexpression has evolved from the identification of the minimal promoter elements necessary for the gene to be transcribed in muscle, to a mechanistic understanding of how the proteins that bind these DNA elements work together to establish transcriptional competence. Here we present our current understanding of the developmental regulation of gene expression gained from studies of theMyoggene.

scholarly journals Temporal and Spatial Regulation of Gene Expression During Asexual Development ofNeurospora crassa

Genetics ◽  
2010 ◽  
Vol 186 (4) ◽  
pp. 1217-1230 ◽  
Author(s):  
Charles J. Greenwald ◽  
Takao Kasuga ◽  
N. Louise Glass ◽  
Brian D. Shaw ◽  
Daniel J. Ebbole ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulation Of Gene Expression ◽  
Asexual Development ◽  
Spatial Regulation ◽  
Ofneurospora Crassa ◽  
Temporal And Spatial

Linking transcription, RNA polymerase II elongation and alternative splicing

2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt
Keyword(s):  
Gene Expression ◽  
Alternative Splicing ◽  
Rna Polymerase Ii ◽  
Environmental Changes ◽  
Transcription Elongation ◽  
Single Gene ◽  
Regulation Of Gene Expression ◽  
Regulation Of Transcription ◽  
Stepping Stones ◽  
Eukaryotic Transcription

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.

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