scholarly journals Osteopontin contributes to late-onset asthma phenotypes in adult asthma patients

2020 ◽  
Vol 52 (2) ◽  
pp. 253-265
Author(s):  
Hoang Kim Tu Trinh ◽  
Thuy Van Thao Nguyen ◽  
Seo-Hee Kim ◽  
Thi Bich Tra Cao ◽  
Quoc Quang Luu ◽  
...  
Keyword(s):  
Late Onset ◽  
Adult Asthma ◽  
Asthma Phenotypes ◽  
Asthma Patients

scholarly journals Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes

2015 ◽  
Vol 46 (3) ◽  
pp. 688-696 ◽  
Author(s):  
Guus A. Westerhof ◽  
Daniël A. Korevaar ◽  
Marijke Amelink ◽  
Selma B. de Nijs ◽  
Jantina C. de Groot ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Operating Characteristics ◽  
Total Ige ◽  
Adult Asthma ◽  
Asthma Phenotypes ◽  
Sputum Eosinophilia ◽  
Asthma Patients ◽  
Outpatient Departments ◽  
Nonobese Patients ◽  
Blood Eosinophils

Several biomarkers have been used to assess sputum eosinophilia in asthma. It has been suggested that the diagnostic accuracy of these biomarkers might differ between asthma phenotypes. We investigated the accuracy of biomarkers in detecting sputum eosinophilia (≥3%) in different adult asthma phenotypes.Levels of eosinophils in blood and sputum, exhaled nitric oxide fraction (FeNO) and total immunoglobulin (Ig)E from 336 adult patients, enrolled in three prospective observational clinical trials and recruited at five pulmonology outpatient departments, were analysed. Areas under the receiver operating characteristics curves (AUC) for detecting sputum eosinophilia were calculated and compared between severe and mild, obese and nonobese, atopic and nonatopic and (ex-)smoking and never-smoking asthma patients.Sputum eosinophilia was present in 116 patients (35%). In the total group the AUC was 0.83 (95% CI 0.78–0.87) for blood eosinophils, 0.82 (0.77–0.87) for FeNO and 0.69 (0.63–0.75) for total IgE. AUCs were similar for blood eosinophils and FeNO between different phenotypes. Total IgE was less accurate in detecting sputum eosinophilia in atopic and obese patients than in nonatopic and nonobese patients.Blood eosinophils and FeNO had comparable diagnostic accuracy (superior to total IgE) in identifying sputum eosinophilia in adult asthma patients, irrespective of asthma phenotype such as severe, nonatopic, obese and smoking-related asthma.

Developing Episodes of Care for Adult Asthma Patients: A Cautionary Tale*†

1998 ◽  
Vol 13 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Amy K. Rosen ◽  
Robert L. Houchens ◽  
Teresa B. Gibson ◽  
Allison Mayer-Oakes
Keyword(s):  
Cautionary Tale ◽  
Adult Asthma ◽  
Asthma Patients ◽  
Episodes Of Care

scholarly journals Clinical and functional differences between early-onset and late-onset adult asthma: a population-based Tasmanian Longitudinal Health Study

Thorax ◽  
2016 ◽  
Vol 71 (11) ◽  
pp. 981-987 ◽  
Author(s):  
Daniel J Tan ◽  
E Haydn Walters ◽  
Jennifer L Perret ◽  
John A Burgess ◽  
David P Johns ◽  
...  
Keyword(s):  
Early Onset ◽  
Late Onset ◽  
Population Based ◽  
Health Study ◽  
Adult Asthma ◽  
Functional Differences

Positive Expiratory Pressure: A Potential Therapy to Mitigate Acute Bronchoconstriction in the Asthma of Obesity

2021 ◽  
Author(s):  
Swati a. Bhatawadekar ◽  
Anne E. Dixon ◽  
Ubong Peters ◽  
Nirav Daphtary ◽  
Kevin Hodgdon ◽  
...  
Keyword(s):  
Airway Resistance ◽  
Late Onset ◽  
Rescue Therapy ◽  
Pharmacologic Therapy ◽  
Airway Closure ◽  
Airway Narrowing ◽  
Asthma Patients ◽  
Peripheral Airway ◽  
Central Airway ◽  
Positive Expiratory Pressure

Late-onset non-allergic (LONA) asthma in obesity is characterized by increased peripheral airway closure secondary to abnormally collapsible airways. We hypothesized that positive expiratory pressure (PEP) would mitigate the tendency to airway closure during bronchoconstriction, potentially serving as rescue therapy for LONA asthma of obesity. The PC20 dose of methacholine was determined in 18 obese participants with LONA asthma. At each of 4 subsequent visits, we used oscillometry to measure input respiratory impedance (Zrs) over 8 minutes; participants received their PC20 concentration of methacholine aerosol during the first 4.5 minutes. PEP combinations of either 0 or 10 cmH2O either during and/or after the methacholine delivery were applied, randomized between visits. Parameters characterizing respiratory system mechanics were extracted from the Zrs spectra. In 18 LONA asthma patients (14 females, BMI: 39.6±3.4 kg/m2), 10 cmH2O PEP during methacholine reduced elevations in the central airway resistance, peripheral airway resistance and elastance, and breathing frequency was also reduced. During the 3.5 min following methacholine delivery, PEP of 10 cmH2O reduced Ax and peripheral elastance compared to no PEP. PEP mitigates the onset of airway narrowing brought on by methacholine challenge, and airway closure once it is established. PEP thus might serve as a non-pharmacologic therapy to manage acute airway narrowing for obese LONA asthma.

P111 CD-14 gene polymorphism in adult asthma patients with eosinophilic versus neutrophilic sputum in crimea

2016 ◽  
Vol 117 (5) ◽  
pp. S53
Author(s):  
Y. Bisyuk ◽  
A. Kurchenko ◽  
O. Akhtemiichuk ◽  
A. Dubovyi ◽  
L. DuBuske
Keyword(s):  
Gene Polymorphism ◽  
Adult Asthma ◽  
Asthma Patients

scholarly journals Acute non-atopic late-onset asthma induced by respiratory infection

2005 ◽  
pp. 53-57
Author(s):  
S. A. Sobchenko ◽  
O. S. Schetchikova ◽  
N. V. Yakovleva
Keyword(s):  
Respiratory Infection ◽  
Influenza A ◽  
Viral Infections ◽  
Late Onset ◽  
Lavage Fluid ◽  
Atopic Asthma ◽  
Influenza A Viruses ◽  
Asthma Patients ◽  
Bacterial Associations ◽  
Autumn And Winter

The aim of the study was to investigate features of respiratory infection inducing acute non-atopic late-onset asthma (NLA). Virologic and microbiologic examinations of brash biopsy samples of rhinopharyngeal and bronchial mucosa and bronchial lavage fluid were performed in 116 NLA patients admitted to a hospital in autumn and winter. The leading cause of acute NLA was found to be respiratory viral infections. We noted that different clinical NLA types had different sensibility to various viruses: adenoviruses mainly caused exacerbations of aspirin-induced asthma, respiratory syncytial and influenza A viruses were prevalently determined in non-atopic asthma. Patients with posttuberculotic lesions of the lungs mostly had viral and bacterial associations. Such mixed infection resulted in more severe and prolonged exacerbations of NLA.

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