scholarly journals Herpes simplex virus-binding IgG traps HSV in human cervicovaginal mucus across the menstrual cycle and diverse vaginal microbial composition

2018 ◽  
Vol 11 (5) ◽  
pp. 1477-1486 ◽  
Author(s):  
Holly A. Schroeder ◽  
Kenetta L. Nunn ◽  
Alison Schaefer ◽  
Christine E. Henry ◽  
Felix Lam ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Menstrual Cycle ◽  
Virus Binding ◽  
Microbial Composition ◽  
Simplex Virus ◽  
Cervicovaginal Mucus

scholarly journals The Effect of Hormonal Contraception and Menstrual Cycle Timing on Genital Herpes Simplex Virus-2 Shedding and Lesions

2019 ◽  
Vol 46 (1) ◽  
pp. 58-62
Author(s):  
Elizabeth Micks ◽  
Hyunju Son ◽  
Amalia Magaret ◽  
Stacy Selke ◽  
Christine Johnston ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Menstrual Cycle ◽  
Genital Herpes ◽  
Hormonal Contraception ◽  
Simplex Virus ◽  
Herpes Simplex Virus 2

scholarly journals Function of Dynein and Dynactin in Herpes Simplex Virus Capsid Transport

2002 ◽  
Vol 13 (8) ◽  
pp. 2795-2809 ◽  
Author(s):  
Katinka Döhner ◽  
André Wolfstein ◽  
Ute Prank ◽  
Christophe Echeverri ◽  
Denis Dujardin ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Cytoplasmic Dynein ◽  
Transport Processes ◽  
Viral Envelope ◽  
Cell Periphery ◽  
Virus Binding ◽  
Viral Protein Synthesis ◽  
Simplex Virus

After fusion of the viral envelope with the plasma membrane, herpes simplex virus type 1 (HSV1) capsids are transported along microtubules (MTs) from the cell periphery to the nucleus. The motor ATPase cytoplasmic dynein and its multisubunit cofactor dynactin mediate most transport processes directed toward the minus-ends of MTs. Immunofluorescence microscopy experiments demonstrated that HSV1 capsids colocalized with cytoplasmic dynein and dynactin. We blocked the function of dynein by overexpressing the dynactin subunit dynamitin, which leads to the disruption of the dynactin complex. We then infected such cells with HSV1 and measured the efficiency of particle binding, virus entry, capsid transport to the nucleus, and the expression of immediate-early viral genes. High concentrations of dynamitin and dynamitin-GFP reduced the number of viral capsids transported to the nucleus. Moreover, viral protein synthesis was inhibited, whereas virus binding to the plasma membrane, its internalization, and the organization of the MT network were not affected. We concluded that incoming HSV1 capsids are propelled along MTs by dynein and that dynein and dynactin are required for efficient viral capsid transport to the nucleus.

scholarly journals Inhibition of herpes simplex virus infection by lactoferrin is dependent on interference with the virus binding to glycosaminoglycans

Virology ◽  
2004 ◽  
Vol 318 (1) ◽  
pp. 405-413 ◽  
Author(s):  
Magda Marchetti ◽  
Edward Trybala ◽  
Fabiana Superti ◽  
Maria Johansson ◽  
Tomas Bergström
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Infection ◽  
Herpes Simplex Virus Infection ◽  
Virus Binding ◽  
Simplex Virus
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