scholarly journals Modulation of intestinal microbiota by glycyrrhizic acid prevents high-fat diet-enhanced pre-metastatic niche formation and metastasis

2019 ◽  
Vol 12 (4) ◽  
pp. 945-957 ◽  
Author(s):  
Miao Qiu ◽  
Keqing Huang ◽  
Yanzhuo Liu ◽  
Yuqing Yang ◽  
Honglin Tang ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Glycyrrhizic Acid ◽  
High Fat ◽  
Metastatic Niche ◽  
Niche Formation

scholarly journals Dysbiosis of intestinal microbiota in early life aggravates high-fat diet induced dysmetabolism in adult mice

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Z. H. Miao ◽  
W. X. Zhou ◽  
R. Y. Cheng ◽  
H. J. Liang ◽  
F. L. Jiang ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Early Life ◽  
Fasting Blood Glucose ◽  
Fecal Microbiota ◽  
Long Term Effects ◽  
High Fat ◽  
Host Animal ◽  
Intestinal Microbes ◽  
Lipid Metabolism Disorders

Abstract Background Accumulating evidence have shown that the intestinal microbiota plays an important role in prevention of host obesity and metabolism disorders. Recent studies also demonstrate that early life is the key time for the colonization of intestinal microbes in host. However, there are few studies focusing on possible association between intestinal microbiota in the early life and metabolism in adulthood. Therefore the present study was conducted to examine whether the short term antibiotic and/or probiotic exposure in early life could affect intestinal microbes and their possible long term effects on host metabolism. Results A high-fat diet resulted in glucose and lipid metabolism disorders with higher levels of visceral fat rate, insulin-resistance indices, and leptin. Exposure to ceftriaxone in early life aggravated the negative influences of a high-fat diet on mouse physiology. Orally fed TMC3115 protected mice, especially those who had received treatment throughout the whole study, from damage due to a high-fat diet, such as increases in levels of fasting blood glucose and serum levels of insulin, leptin, and IR indices. Exposure to ceftriaxone during the first 2 weeks of life was linked to dysbiosis of the fecal microbiota with a significant decrease in the species richness and diversity. However, the influence of orally fed ceftriaxone on the fecal microbiota was limited to 12 weeks after the termination of treatment. Of note, at week 12 there were still some differences in the composition of intestinal microbiota between mice provided with high fat diet and antibiotic exposure and those only fed a high fat diet. Conclusions These results indicated that exposure to antibiotics, such as ceftriaxone, in early life may aggravate the negative influences of a high-fat diet on the physiology of the host animal. These results also suggest that the crosstalk between the host and their intestinal microbiota in early life may be more important than that in adulthood, even though the same intestinal microbes are present in adulthood.

scholarly journals Perinatal short‐chain fructooligosaccharides program intestinal microbiota and improve enteroinsular axis function and inflammatory status in high‐fat diet‐fed adult pigs

2018 ◽  
Vol 33 (1) ◽  
pp. 301-313 ◽  
Author(s):  
Cindy Le Bourgot ◽  
Stéphanie Ferret‐Bernard ◽  
Emmanuelle Apper ◽  
Bernard Taminiau ◽  
Armelle Cahu ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Short Chain ◽  
High Fat ◽  
Enteroinsular Axis ◽  
Inflammatory Status

Corn starch dextrin changes intestinal microbiota and its metabolic activity in rats fed a basal and high-fat diet

2019 ◽  
Vol 121 (9) ◽  
pp. 2219-2232 ◽  
Author(s):  
Renata Barczynska ◽  
Adam Jurgoński ◽  
Katarzyna Slizewska ◽  
Jerzy Juśkiewicz ◽  
Janusz Kapusniak
Keyword(s):  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Corn Starch ◽  
Enteric Bacteria ◽  
High Fat ◽  
Low Fat ◽  
Content Type ◽  
High Fat Diets ◽  
Fat Diets

Purpose The purpose of this paper is to determine the influence of low-fat and high-fat diets supplemented with dextrin obtained from corn starch on the numbers and relative proportions of enteric bacteria Bacteroidetes (Bacteroides, Prevotella), Actinobacteria (Bifidobacterium) and Firmicutes (Clostridium, Lactobacillus). Moreover, basic indicators of gastrointestinal function (among other things: epidydymal fat mass, mass with contents, pH in the colon, cecum, small intestine, fecal enzymes were investigation) and short-chain fatty acids are analyzed. Design/methodology/approach In vivo experimental studies in rats (analized samples of the ileal, cecal and colonic digesta; pH; blood serum; fecal enzymes); determination of the number of bacteria – fluorescence in situ hybridization; and determination of type and concentration SCFA – HPLC were considered. Findings No statistically significant differences in final body weight were found between rats fed low-fat and high-fat diets supplemented with dextrin. In rats fed the low-fat diet with dextrin, the gut microbiota composition was as follows: 42.74 percent Bacteroises and Prevotella (Bacteroidetes), 35.28 percent Clostridium and Lactobacilllus (Firmicutes) and 21.98 percent Bifidobacterium (Actinobacteria), while in rats fed the high-fat diet with dextrin it was similar. Irrespective of the diet type, supplementation with dextrin enhances bacterial glycolytic activity and the cecal production of total SCFAs, with strongly increased propionate and decreased butyrate fermentation. Practical implications Dextrin may enrich food or be a component of functional foods. Originality/value Dextrin from corn starch may contribute to changes in the composition of intestinal microbiota.

Pediococcus pentosaceus PP04 improves high-fat diet induced liver injury by modulation of gut inflammation and intestinal microbiota in C57BL/6N mice

2021 ◽  
Author(s):  
Yu Wang ◽  
Yuan Tian ◽  
Nan Zhang ◽  
Xia Li ◽  
Xiujuan Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
High Fat ◽  
Gut Inflammation ◽  
Pediococcus Pentosaceus

Abstract: In this study, Pediococcus pentococcus PP04 (PP04) isolated from the Northeast pickled cabbage was given to C57BL/6N mice for eight weeks, which aimed to investigate the ameliorative effects of...

scholarly journals Refined versus Extra Virgin Olive Oil High-Fat Diet Impact on Intestinal Microbiota of Mice and Its Relation to Different Physiological Variables

2019 ◽  
Vol 7 (2) ◽  
pp. 61 ◽  
Author(s):  
Nieves Martínez ◽  
Isabel Prieto ◽  
Marina Hidalgo ◽  
Ana Segarra ◽  
Ana Martínez-Rodríguez ◽  
...  
Keyword(s):  
Olive Oil ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Physiological Parameters ◽  
Minor Components ◽  
High Fat ◽  
Physiological Variables ◽  
Physiological Benefits

Extra virgin olive oil (EVOO) has been reported to have a distinct influence on gut microbiota in comparison to other fats, with its physiological benefits widely studied. However, a large proportion of the population consumes olive oil after a depurative process that not only mellows its taste, but also deprives it of polyphenols and other minority components. In this study, we compare the influence on the intestinal microbiota of a diet high in this refined olive oil (ROO) with other fat-enriched diets. Swiss Webster mice were fed standard or a high-fat diet enriched with EVOO, ROO, or butter (BT). Physiological parameters were also evaluated. At the end of the feeding period, DNA was extracted from feces and the 16S rRNA was pyrosequenced. The group fed ROO behaved differently to the EVOO group in half the families with statistically significant differences among the diets, with higher comparative levels in three families—Desulfovibrionaceae, Spiroplasmataceae, and Helicobacteraceae—correlating with total cholesterol. These results are again indicative of a link between specific diets, certain physiological parameters and the prevalence of some taxa, but also support the possibility that polyphenols and minor components of EVOO are involved in some of the proposed effects of this fat through the modulation of the intestinal microbiota

scholarly journals Inulin from Jerusalem artichoke tubers alleviates hyperglycaemia in high-fat-diet-induced diabetes mice through the intestinal microflora improvement

2019 ◽  
Vol 123 (3) ◽  
pp. 308-318 ◽  
Author(s):  
Tianyun Shao ◽  
Qiuhong Yu ◽  
Tingshuo Zhu ◽  
Anhong Liu ◽  
Xiumei Gao ◽  
...  
Keyword(s):  
Differentially Expressed Genes ◽  
Intestinal Microbiota ◽  
High Fat Diet ◽  
High Throughput Sequencing ◽  
Fasting Blood Glucose ◽  
Jerusalem Artichoke ◽  
Differentially Expressed ◽  
High Fat ◽  
Blood Concentrations ◽  
Linear Discriminant

AbstractThe rate of hyperglycaemia in people around the world is increasing at an alarming rate at present, and innovative methods of alleviating hyperglycaemia are needed. The effects of Jerusalem artichoke inulin on hyperglycaemia, liver-related genes and the intestinal microbiota in mice fed a high-fat diet (HFD) and treated with streptozotocin (STZ) to induce hyperglycaemia were investigated. Inulin-treated hyperglycaemic mice had decreased average daily food consumption, body weight, average daily water consumption and relative liver weight and blood concentrations of TAG, total cholesterol, HDL-cholesterol and fasting blood glucose. Liver-related gene expressions in hyperglycaemic (HFD-fed and STZ-treated) compared with control mice showed eighty-four differentially expressed genes (forty-nine up-regulated and thirty-five down-regulated). In contrast, hyperglycaemic mice treated with inulin had twenty-two differentially expressed genes compared with control ones. Using Illumina high-throughput sequencing technology, the rarefaction and the rank abundance curves as well as the α diversity indices showed the treatment-induced differences in bacterial diversity in intestine. The linear discriminant analysis of effect size showed that the inulin treatment improved intestinal microbiota; in particular, it significantly increased the number of Bacteroides in the intestine of mice. In conclusion, inulin is potentially an effective functional food for the prevention and/or treatment of hyperglycaemia.

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