Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study

ObjectivesIn England, healthcare policy advocates specialised age-appropriate services for teenagers and young adults (TYA), those aged 13 to 24 years at diagnosis. Specialist Principal Treatment Centres (PTC) provide enhanced TYA age-specific care, although many still receive care in adult or children’s cancer services. We present the first prospective structured analysis of quality of life (QOL) associated with the amount of care received in a TYA-PTCDesignLongitudinal cohort study.SettingHospitals delivering inpatient cancer care in England.Participants1114 young people aged 13 to 24 years newly diagnosed with cancer.InterventionExposure to the TYA-PTC defined as patients receiving NO-TYA-PTC care with those receiving ALL-TYA-PTC and SOME-TYA-PTC care.Primary outcomeQuality of life measured at five time points: 6, 12, 18, 24 and 36 months after diagnosis.ResultsGroup mean total QOL improved over time for all patients, but for those receiving NO-TYA-PTC was an average of 5.63 points higher (95% CI 2.77 to 8.49) than in young people receiving SOME-TYA-PTC care, and 4·17 points higher (95% CI 1.07 to 7.28) compared with ALL-TYA-PTC care. Differences were greatest 6 months after diagnosis, reduced over time and did not meet the 8-point level that is proposed to be clinically significant. Young people receiving NO-TYA-PTC care were more likely to have been offered a choice of place of care, be older, from more deprived areas, in work and have less severe disease. However, analyses adjusting for confounding factors did not explain the differences between TYA groups.ConclusionsReceipt of some or all care in a TYA-PTC was associated with lower QOL shortly after cancer diagnosis. The NO-TYA-PTC group had higher QOL 3 years after diagnosis, however those receiving all or some care in a TYA-PTC experienced more rapid QOL improvements. Receipt of some care in a TYA-PTC requires further study.

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Optimizing a Retention Strategy with Young People for BRIGHTLIGHT, a Longitudinal Cohort Study Examining the Value of Specialist Cancer Care for Young People

Journal of Adolescent and Young Adult Oncology ◽

10.1089/jayao.2016.0085 ◽

2017 ◽

Vol 6 (3) ◽

pp. 459-469 ◽

Cited By ~ 8

Author(s):

Rachel M. Taylor ◽

Natasha Aslam ◽

Sarah Lea ◽

Jeremy S. Whelan ◽

Lorna A. Fern

Keyword(s):

Cohort Study ◽

Young People ◽

Cancer Care ◽

Longitudinal Cohort Study ◽

Retention Strategy ◽

Longitudinal Cohort

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Heavy episodic drinking and deliberate self-harm in young people: a longitudinal cohort study

Addiction ◽

10.1111/add.12527 ◽

2014 ◽

Vol 109 (6) ◽

pp. 930-936 ◽

Cited By ~ 8

Author(s):

Ingeborg Rossow ◽

Thor Norström

Keyword(s):

Cohort Study ◽

Young People ◽

Heavy Episodic Drinking ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort ◽

Deliberate Self Harm ◽

Self Harm

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Development of an individualized risk calculator for poor functioning in young people victimized during childhood: A longitudinal cohort study

Child Abuse & Neglect ◽

10.1016/j.chiabu.2019.104188 ◽

2019 ◽

Vol 98 ◽

pp. 104188 ◽

Cited By ~ 2

Author(s):

Rachel M. Latham ◽

Alan J. Meehan ◽

Louise Arseneault ◽

Daniel Stahl ◽

Andrea Danese ◽

...

Keyword(s):

Cohort Study ◽

Young People ◽

Longitudinal Cohort Study ◽

Risk Calculator ◽

Longitudinal Cohort

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Correlates of Common Mental Disorders Among Dutch Women Who Have Had an Abortion: A Longitudinal Cohort Study

Perspectives on Sexual and Reproductive Health ◽

10.1363/psrh.12028 ◽

2017 ◽

Vol 49 (2) ◽

pp. 123-131 ◽

Cited By ~ 8

Author(s):

Jenneke van Ditzhuijzen ◽

Margreet ten Have ◽

Ron de Graaf ◽

Carolus H.C.J. van Nijnatten ◽

Wilma A.M. Vollebergh

Keyword(s):

Cohort Study ◽

Mental Disorders ◽

Common Mental Disorders ◽

Longitudinal Cohort Study ◽

Longitudinal Cohort

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Existential distress in patients with advanced cancer and their caregivers: study protocol of a longitudinal cohort study

BMJ Open ◽

10.1136/bmjopen-2020-046351 ◽

2021 ◽

Vol 11 (4) ◽

pp. e046351

Author(s):

Rebecca Philipp ◽

Anna Kalender ◽

Martin Härter ◽

Carsten Bokemeyer ◽

Karin Oechsle ◽

...

Keyword(s):

Cohort Study ◽

Mental Disorders ◽

End Of Life ◽

Advanced Cancer ◽

Psychosocial Interventions ◽

Longitudinal Cohort Study ◽

Life Outcomes ◽

Longitudinal Cohort ◽

Existential Distress ◽

Existential Concerns

IntroductionAt the end of life, patients with advanced cancer and their informal caregivers may confront multiple existential concerns. Despite the strong potential to alleviate existential distress through psychosocial interventions, existential distress and its impact on healthcare outcomes have not yet been studied systematically. We aim to investigate the frequency, longitudinal trajectory and predictive impact of existential distress on end-of-life outcomes. We further aim to determine patients’ and caregivers’ specific need for and utilisation of psychosocial support for existential distress.MethodsThis longitudinal cohort study will consecutively recruit 500 patients with advanced cancer and 500 caregivers from oncological outpatient and inpatient clinics. Participants will complete self-report questionnaires (sociodemographic and disease-related characteristics, existential distress, end-of-life outcomes, resources and support needs) at five points of assessment (at baseline and after 3, 6, 9 and 12 months). At baseline and 6-month follow-up, we will conduct structured diagnostic interviews to assess mental disorders. Statistical analyses will include descriptive statistics to determine the prevalence of existential distress, mental disorders and end-of-life outcomes; multiple linear and logistic regression analyses to calculate the predictive impact of existential distress on end-of-life outcomes; and growth mixture models to analyse longitudinal trajectories of existential distress.DiscussionThis study will provide comprehensive knowledge about patients’ and caregivers’ existential concerns. The longitudinal empirical data will allow for conclusions concerning the frequency and course of existential distress throughout 1 year. This important extension of existing cross-sectional research will contribute to further develop targeted psychosocial interventions. Profiles of existential distress may be applied by clinicians from multiple professions and help to address existential concerns effectively.Ethics and disseminationThe study was approved by the institutional research ethics committee (reference number LPEK-0177). Results will be presented at scientific conferences and published in peer-reviewed journals. Other forms of dissemination will include sharing results on the psychometric properties of the structured demoralisation interview with international research groups and communication with healthcare professionals providing psychosocial treatment for patients and caregivers. Following scientific standards, our progress will be regularly updated on ClinicalTrials.gov.Trial registration numberNCT04600206.

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