Exploring the oncogenic and therapeutic target potential of the MYB-TYK2 fusion gene in B-cell acute lymphoblastic leukemia

2022 ◽  
Author(s):  
Paniz Tavakoli Shirazi ◽  
Laura N. Eadie ◽  
Susan L. Heatley ◽  
Elyse C. Page ◽  
Maxime François ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Therapeutic Target ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals NG2 antigen is a therapeutic target for MLL-rearranged B-cell acute lymphoblastic leukemia

Leukemia ◽  
2019 ◽  
Vol 33 (7) ◽  
pp. 1557-1569 ◽  
Author(s):  
Belen Lopez-Millan ◽  
Diego Sanchéz-Martínez ◽  
Heleia Roca-Ho ◽  
Francisco Gutiérrez-Agüera ◽  
Oscar Molina ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Therapeutic Target ◽  
Lymphoblastic Leukemia ◽  
Cell Acute Lymphoblastic Leukemia

A fluorescence in situ hybridization study of TEL-AML1 fusion gene in B-cell acute lymphoblastic leukemia (1984–2001)

2003 ◽  
Vol 144 (2) ◽  
pp. 143-147 ◽  
Author(s):  
Nathalie Douet-Guilbert ◽  
Frédéric Morel ◽  
Marie-Josée Le Bris ◽  
Angèle Herry ◽  
Geneviève Le Calvez ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Fluorescence In Situ Hybridization ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Hybridization Study ◽  
Cell Acute Lymphoblastic Leukemia

Episomal amplification of NUP214-ABL1 fusion gene in B-cell acute lymphoblastic leukemia

Blood ◽  
2012 ◽  
Vol 120 (22) ◽  
pp. 4441-4443 ◽  
Author(s):  
Toby Eyre ◽  
Claire J. Schwab ◽  
Ross Kinstrie ◽  
Ann Keen McGuire ◽  
Jen Strefford ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Cell Acute Lymphoblastic Leukemia

CXCR4 Chemokine Receptor as a therapeutic target in B-Cell Acute Lymphoblastic Leukemia (B-ALL)

2015 ◽  
Vol 15 ◽  
pp. S1-S2
Author(s):  
Shubhchintan Randhawa ◽  
Byung Sik Cho ◽  
Dipanjan Ghosh ◽  
Amnon Peled ◽  
Richard E. Davis ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Chemokine Receptor ◽  
Therapeutic Target ◽  
Lymphoblastic Leukemia ◽  
Cell Acute Lymphoblastic Leukemia

scholarly journals Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4Positive B-Cell Acute Lymphoblastic Leukemia

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
F. Marchesi ◽  
K. Girardi ◽  
G. Avvisati
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Cooperative Groups ◽  
Newly Diagnosed ◽  
Treatment Intensification ◽  
Hematopoietic Stem ◽  
Prognostic Features ◽  
Cell Acute Lymphoblastic Leukemia

Translocation t(4;11)(q21;q23) leading to formation ofMLL-AF4fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients. Patients expressing this chromosomal aberration present typical biological, immunophenotypic, and clinical features. This form of leukemia is universally recognized as high-risk leukemia and treatment intensification with allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR) could be a valid option to improve prognosis, but data obtained from the literature are controversial. In this review, we briefly describe pathogenetic, clinical, and prognostic characteristics of adult t(4;11)(q21;q23)/MLL-AF4positive ALL and provide a review of the clinical outcome reported by the most important cooperative groups worldwide.

scholarly journals Philadelphia-positive precursor B-cell acute lymphoblastic leukemia in elderly alcoholic patient – A case report

2019 ◽  
Vol 1 ◽  
pp. 31-33
Author(s):  
Vijay Suri ◽  
Gunjan Bala ◽  
Ramit Gupta ◽  
Shikha Narang ◽  
Anshul Gupta ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Cell Lineage ◽  
Chronic Alcoholism ◽  
Alcoholic Patient ◽  
Delay In Diagnosis ◽  
Cell Acute Lymphoblastic Leukemia

Philadelphia chromosome is well-known chromosomal abnormality in chronic myeloid leukemia (CML). However, B-acute lymphoblastic leukemia (B-ALL) with Philadelphia-positive (Ph′) is a neoplasm of lymphoblast committed to the B-cell lineage. The clinical presentation of B-ALL Ph′+ is similar to B-ALL but is more common in adults than in children. Our 50-year-old male patient presented to psychiatry OPD for deaddiction of alcohol. The patient also complained of generalized weakness and pain in legs which may have been due to chronic alcoholism. He was further investigated and diagnosed as B-precursor ALL with positive BCR-ABL fusion gene. Here, we like to emphasize that overlapping symptoms may lead to delay in diagnosis, so clinician should always investigate the patient thoroughly so that the patient is diagnosed on time and treatment can be started as early as possible and fatal outcomes can be avoided.

Sign in / Sign up

Export Citation Format

Share Document