scholarly journals Pigment epithelium-derived factor mediates retinal ganglion cell neuroprotection by suppression of caspase-2

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Vasanthy Vigneswara ◽  
Zubair Ahmed
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pigment Epithelium ◽  
Retinal Ganglion ◽  
Pigment Epithelium Derived Factor ◽  
Caspase 2

scholarly journals Pigment Epithelium-Derived Factor Gene Therapy Targeting Retinal Ganglion Cell Injuries: Neuroprotection against Loss of Function in Two Animal Models

2011 ◽  
Vol 22 (5) ◽  
pp. 559-565 ◽  
Author(s):  
Masanori Miyazaki ◽  
Yasuhiro Ikeda ◽  
Yoshikazu Yonemitsu ◽  
Yoshinobu Goto ◽  
Yusuke Murakami ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Animal Models ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pigment Epithelium ◽  
Retinal Ganglion ◽  
Loss Of Function ◽  
Factor Gene ◽  
Pigment Epithelium Derived Factor

scholarly journals Caspase-2 Mediates Site-Specific Retinal Ganglion Cell Death After Blunt Ocular Injury

2018 ◽  
Vol 59 (11) ◽  
pp. 4453 ◽  
Author(s):  
Chloe N. Thomas ◽  
Adam M. Thompson ◽  
Eleanor McCance ◽  
Martin Berry ◽  
Ann Logan ◽  
...  
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Ocular Injury ◽  
Retinal Ganglion ◽  
Site Specific ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death ◽  
Caspase 2

Retinal Ganglion Cell Axon Wiring Establishing the Binocular Circuit

2020 ◽  
Vol 6 (1) ◽  
pp. 215-236
Author(s):  
Carol Mason ◽  
Nefeli Slavi
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Molecular Mechanisms ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Optic Tract ◽  
Optic Chiasm ◽  
Retinal Ganglion ◽  
Temporal Features ◽  
Ipsilateral Projection

Binocular vision depends on retinal ganglion cell (RGC) axon projection either to the same side or to the opposite side of the brain. In this article, we review the molecular mechanisms for decussation of RGC axons, with a focus on axon guidance signaling at the optic chiasm and ipsi- and contralateral axon organization in the optic tract prior to and during targeting. The spatial and temporal features of RGC neurogenesis that give rise to ipsilateral and contralateral identity are described. The albino visual system is highlighted as an apt comparative model for understanding RGC decussation, as albinos have a reduced ipsilateral projection and altered RGC neurogenesis associated with perturbed melanogenesis in the retinal pigment epithelium. Understanding the steps for RGC specification into ipsi- and contralateral subtypes will facilitate differentiation of stem cells into RGCs with proper navigational abilities for effective axon regeneration and correct targeting of higher-order visual centers.

scholarly journals Retinal Ganglion Cell Death as a Late Remodeling Effect of Photoreceptor Degeneration

2019 ◽  
Vol 20 (18) ◽  
pp. 4649 ◽  
Author(s):  
Diego García-Ayuso ◽  
Johnny Di Pierdomenico ◽  
Manuel Vidal-Sanz ◽  
María P. Villegas-Pérez
Keyword(s):  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Retinal Ganglion ◽  
Photoreceptor Degeneration ◽  
Inner Retina ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death ◽  
Photoreceptor Degenerations

Inherited or acquired photoreceptor degenerations, one of the leading causes of irreversible blindness in the world, are a group of retinal disorders that initially affect rods and cones, situated in the outer retina. For many years it was assumed that these diseases did not spread to the inner retina. However, it is now known that photoreceptor loss leads to an unavoidable chain of events that cause neurovascular changes in the retina including migration of retinal pigment epithelium cells, formation of “subretinal vascular complexes”, vessel displacement, retinal ganglion cell (RGC) axonal strangulation by retinal vessels, axonal transport alteration and, ultimately, RGC death. These events are common to all photoreceptor degenerations regardless of the initial trigger and thus threaten the outcome of photoreceptor substitution as a therapeutic approach, because with a degenerating inner retina, the photoreceptor signal will not reach the brain. In conclusion, therapies should be applied early in the course of photoreceptor degeneration, before the remodeling process reaches the inner retina.

scholarly journals Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2

2021 ◽  
Vol 152 ◽  
pp. 105277
Author(s):  
Jennifer Ngolab ◽  
Saranya Canchi ◽  
Suhail Rasool ◽  
Abderrahman Elmaarouf ◽  
Kimberly Thomas ◽  
...  
Keyword(s):  
Cell Death ◽  
Ganglion Cell ◽  
Retinal Ganglion Cell ◽  
Retinal Ganglion ◽  
Retinal Ganglion Cell Death ◽  
Ganglion Cell Death ◽  
Caspase 2 ◽  
Tau Expression
Sign in / Sign up

Export Citation Format

Share Document