Optical molecular imaging can differentiate metastatic from benign lymph nodes in head and neck cancer

Abstract Identification of lymph node (LN) metastasis is essential for staging of solid tumors, and as a result, surgeons focus on harvesting significant numbers of LNs during ablative procedures for pathological evaluation. Isolating those LNs most likely to harbor metastatic disease can allow for a more rigorous evaluation of fewer LNs. Here we evaluate the impact of a systemically injected, near-infrared fluorescently-labeled, tumor-targeting contrast agent, panitumumab-IRDye800CW, to facilitate the identification of metastatic LNs in the ex vivo setting for head and neck cancer patients. Molecular imaging demonstrates a significantly higher mean fluorescence signal in metastatic LNs compared to benign LNs in head and neck cancer patients undergoing an elective neck dissection. Molecular imaging to preselect at-risk LNs may thus allow a more rigorous examination of LNs and subsequently lead to improved prognostication than regular neck dissection.

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The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy

International Journal of Radiation Oncology*Biology*Physics ◽

10.1016/j.ijrobp.2006.09.021 ◽

2007 ◽

Vol 67 (3) ◽

pp. 660-669 ◽

Cited By ~ 137

Author(s):

Yun Li ◽

Jeremy M.G. Taylor ◽

Randall K. Ten Haken ◽

Avraham Eisbruch

Keyword(s):

Radiation Therapy ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

The Impact

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Impact of Tracheal Tube on Swallowing in Post-Operative Head and Neck Cancer Patients: Scintigraphic Analysis

Dysphagia ◽

10.1007/s00455-020-10222-y ◽

2020 ◽

Author(s):

Jacopo Galli ◽

Maria Raffaella Marchese ◽

Tiziana Di Cesare ◽

Laura Tricarico ◽

Giovanni Almadori ◽

...

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Tracheal Tube ◽

Transit Time ◽

Neck Cancer ◽

Retention Index ◽

Small Diameter ◽

Swallowing Rehabilitation ◽

The Impact

AbstractDysphagia is common in tracheostomized patients who underwent head and neck surgery for cancer treatment. The objective of this study was to evaluate, by means of oropharyngoesophageal scintigraphy (OPES), the impact of an occluded tracheal tube (TT) on swallowing in patients treated for head and neck cancer before hospital discharge, to provide further information to the benefit of out-patient care management. From October 2018 to November 2019, we enrolled 19 tracheostomized patients (6 females and 13 males; mean age 61 years) who underwent primary surgical resection of head and neck tumor and swallowing rehabilitation during hospitalization. All subjects underwent a double-standard OPES, one with occluded tracheal tube and the other without TT, with their tracheal stoma being closed directly by a plaster. For each study, we assessed and compared the following quantitative parameters: oral transit time (OTTsec), pharyngeal transit time (PTTsec), esophageal transit time (ETTsec), oral retention index (ORI%), pharyngeal retention index (PRI%), esophageal retention index (ERI%), and aspiration percentage (AP%). The mean values of OTT, PTT, ORI%, PRI%, and ERI% were abnormal during OPES both with TT and without TT and did not statistically differ between the two tests (p > 0.05). Aspiration was detected in 4 cases out of 19 (21.05%) cases during OPES with TT and in 4/19 (21.05%) cases without TT who showed a mean AP% of 11.4% and 11.5% respectively (p > 0.05). Patients with abnormal AP% (> 0%) during OPES with TT showed aspiration signs without TT. Our study showed that the mere presence of a closed tracheal tube does not impact significantly the oropharyngeal transit of bolus during swallowing. This result suggests the possibility to maintain a small-diameter occluded tracheal tube in place for the postsurgical management of head and neck cancer patients.

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The impact of the COVID-19 pandemic on head and neck cancer patients

Oral Oncology ◽

10.1016/j.oraloncology.2020.104881 ◽

2020 ◽

Vol 110 ◽

pp. 104881 ◽

Cited By ~ 2

Author(s):

Gaili Chen ◽

Qiuji Wu ◽

Huangang Jiang ◽

Yahua Zhong

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

The Impact

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Intraoperative Tumor Assessment Using Real-Time Molecular Imaging in Head and Neck Cancer Patients

Journal of the American College of Surgeons ◽

10.1016/j.jamcollsurg.2019.09.007 ◽

2019 ◽

Vol 229 (6) ◽

pp. 560-567.e1 ◽

Cited By ~ 6

Author(s):

Stan van Keulen ◽

Naoki Nishio ◽

Shayan Fakurnejad ◽

Nynke S. van den Berg ◽

Guolan Lu ◽

...

Keyword(s):

Head And Neck Cancer ◽

Molecular Imaging ◽

Head And Neck ◽

Real Time ◽

Cancer Patients ◽

Neck Cancer

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The Development and Treatment of Lymphatic Dysfunction in Cancer Patients and Survivors

Cancers ◽

10.3390/cancers12082280 ◽

2020 ◽

Vol 12 (8) ◽

pp. 2280

Author(s):

Melissa B. Aldrich ◽

John C. Rasmussen ◽

Caroline E. Fife ◽

Simona F. Shaitelman ◽

Eva M. Sevick-Muraca

Keyword(s):

Breast Cancer ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Cancer Progression ◽

Neck Cancer ◽

Cancer Metastasis ◽

Near Infrared ◽

Critical Role ◽

Lymphatic Function

Breast-cancer-acquired lymphedema is routinely diagnosed from the appearance of irreversible swelling that occurs as a result of lymphatic dysfunction. Yet in head and neck cancer survivors, lymphatic dysfunction may not always result in clinically overt swelling, but instead contribute to debilitating functional outcomes. In this review, we describe how cancer metastasis, lymph node dissection, and radiation therapy alter lymphatic function, as visualized by near-infrared fluorescence lymphatic imaging. Using custom gallium arsenide (GaAs)-intensified systems capable of detecting trace amounts of indocyanine green administered repeatedly as lymphatic contrast for longitudinal clinical imaging, we show that lymphatic dysfunction occurs with cancer progression and treatment and is an early, sub-clinical indicator of cancer-acquired lymphedema. We show that early treatment of lymphedema can restore lymphatic function in breast cancer and head and neck cancer patients and survivors. The compilation of these studies provides insights to the critical role that the lymphatics and the immune system play in the etiology of lymphedema and associated co-morbidities.

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