scholarly journals Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses

npj Vaccines ◽  
2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Edmond J. Remarque ◽  
Bart W. Faber ◽  
Roberto Rodriguez Garcia ◽  
Herman Oostermeijer ◽  
Sodiomon B. Sirima ◽  
...  
Keyword(s):  
Immune Responses ◽  
Malaria Vaccine ◽  
Vaccine Antigen ◽  
Future Research ◽  
Apical Membrane Antigen 1 ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Naturally Occurring ◽  
Candidate Malaria Vaccine ◽  
Malaria Vaccine Candidate

AbstractPlasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversity Covering (DiCo) protein sequences were designed and tested in a staggered phase Ia/b trial. A cohort of malaria-naive adults received PfAMA1-DiCo adjuvanted with Alhydrogel® or GLA-SE and a cohort of malaria-exposed adults received placebo or GLA-SE adjuvanted PfAMA1 DiCo at weeks 0, 4 and 26. IgG and GIA levels measured 4 weeks after the third vaccination are similar in malaria-naive volunteers and placebo-immunised malaria-exposed adults, and have a similar breadth. Vaccination of malaria-exposed adults results in significant antibody level increases to the DiCo variants, but not to naturally occurring PfAMA1 variants. Moreover, GIA levels do not increase following vaccination. Future research will need to focus on stronger adjuvants and/or adapted vaccination regimens, to induce potentially protective responses in the target group of the vaccine.

Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon

Cytokine ◽  
2015 ◽  
Vol 74 (2) ◽  
pp. 273-278 ◽  
Author(s):  
Franciele Maira Moreira Batista Tomaz ◽  
Adriana Antônia da Cruz Furini ◽  
Marcela Petrolini Capobianco ◽  
Marinete Marins Póvoa ◽  
Pamella Cristina Alves Trindade ◽  
...  
Keyword(s):  
Immune Responses ◽  
Endemic Area ◽  
Malaria Vaccine ◽  
Vaccine Candidate ◽  
Brazilian Amazon ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Vaccine Candidate Antigen ◽  
Malaria Vaccine Candidate ◽  
Candidate Antigen

Humoral immune responses during a malaria vaccine trial in Tanzanian infants

2000 ◽  
Vol 22 (9) ◽  
pp. 437-443 ◽  
Author(s):  
Galindo ◽  
Acosta ◽  
Schellenberg ◽  
Aponte ◽  
Roca ◽  
...  
Keyword(s):  
Immune Responses ◽  
Malaria Vaccine ◽  
Vaccine Trial ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Breadth of humoral immune responses to the C-terminus of the circumsporozoite protein is associated with protective efficacy induced by the RTS,S malaria vaccine

2020 ◽  
Author(s):  
Sidhartha Chaudhury ◽  
Randall S. MacGill ◽  
Angela M. Early ◽  
Jessica S. Bolton ◽  
C. Richter King ◽  
...  
Keyword(s):  
Immune Responses ◽  
Malaria Vaccine ◽  
Protective Efficacy ◽  
Cross Reactivity ◽  
Antibody Responses ◽  
Circumsporozoite Protein ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
C Terminus ◽  
Fold Reduction

AbstractThe circumsporozoite protein (CSP) is the main surface antigen of malaria sporozoites and a prime vaccine target. Responses induced by the CSP-based RTS,S vaccine towards the polymorphic C-terminal region of P.falciparum-CSP raise concerns that vaccines using single alleles may have lower efficacy against genotypic variants. We characterized the extent of C-terminal cross-reactivity of antibodies induced by RTS,S (based on the 3D7 allele) with variants representing seven circulating field isolates through a novel HTS-multiplex assay for screening closely related peptides. Reactivity to variants showed approximately 30-fold reduction in recognition relative to 3D7. The degree of reduced cross-reactivity,ranging from 21 to 69-fold, directly correlated with the number of polymorphisms between variants and 3D7. Surprisingly, protection assessed by challenge with 3D7 parasites was strongly associated with higher C-terminal antibody breadth suggesting that C-terminal specific avidity or fine-specificity may play a role in RTS,S/AS01B-mediated protection and that breadth of C-terminal CSP-specific antibody responses may be a marker of protection.

scholarly journals Atraumatic Oral Spray Immunization with Replication-Deficient Viral Vector Vaccines

2007 ◽  
Vol 81 (23) ◽  
pp. 13180-13190 ◽  
Author(s):  
Christiane Stahl-Hennig ◽  
Seraphin Kuate ◽  
Monika Franz ◽  
You S. Suh ◽  
Heribert Stoiber ◽  
...  
Keyword(s):  
Immune Responses ◽  
Viral Vector ◽  
Rhesus Macaques ◽  
Vaccine Antigen ◽  
Lymphatic Tissue ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Novel Approach ◽  
Immunodeficiency Virus ◽  
Vaccines For Children

ABSTRACT The development of needle-free vaccines is one of the recently defined “grand challenges in global health” (H. Varmus, R. Klausner, R. Klausner, R. Zerhouni, T. Acharya, A. S. Daar, and P. A. Singer, Science 302:398-399, 2003). To explore whether a natural pathway to the inductive site of the mucosa-associated lymphatic tissue could be exploited for atraumatic immunization purposes, replication-deficient viral vector vaccines were sprayed directly onto the tonsils of rhesus macaques. Tonsillar immunization with viral vector vaccines encoding simian immunodeficiency virus (SIV) antigens induced cellular and humoral immune responses. Viral RNA levels after a stringent SIV challenge were reduced, providing a level of protection similar to that observed after systemic immunization with the same vaccines. Thus, atraumatic oral spray immunization with replication-deficient vectors can overcome the epithelial barrier, deliver the vaccine antigen to the mucosa-associated lymphatic tissue, and avoid induction of tolerance, providing a novel approach to circumvent acceptability problems of syringe and needle vaccines for children and in developing countries.

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization
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