Reference value of left and right atrial size and phasic function by SSFP CMR at 3.0 T in healthy Chinese adults

Abstract The left and right atrial (LA and RA) volumes and function are tightly linked to the morbidity and mortality of multiple cardiovascular diseases. We aimed to establish cardiovascular magnetic resonance (CMR) reference values for LA and RA volumes and phasic function based on a large sample of healthy Chinese adults. 408 validated healthy Chinese adults (54% men; aged 21–70 years) were included. The atrial volumes: maximum, minimum, and pre-atrial contraction (Vmax, Vmin, and Vpac); atrial phasic emptying fractions: total, passive, and booster (EF total, EF passive, and EF booster); atrial phasic emptying volumes: total, passive, and active (TEV, PEV, and AEV); and atrial expansion index (EI) were measured. Normal reference values were calculated and were stratified by sex (men and women) and age decades. The absolute LA and RA volumes and the indexed RA volumes were all greater in men. Women demonstrated higher LAEF total, LAEF booster, LAEI, RAEF total, RAEF passive, RAEF booster, and RAEI, while men had greater RATEV and RAAEV. Aging was positively correlated with the absolute and indexed LA and RA volumes, except for LA Vmax. LA and RA reservoir and conduit function including EF total, EI, EF passive, and PEV increased with age, while the atrial booster function (EF booster and AEV) decreased. We systematically provide age- and sex-specific CMR reference values for LA, RA volumes and phasic function based on a large sample of healthy Chinese adults with a wide age range. Both age and sex are closely associated with atrial volumes and function.

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Left and right atrial size and the occurrence predictors in patients with paroxysmal atrial fibrillation

International Journal of Cardiology ◽

10.1016/j.ijcard.2007.07.006 ◽

2008 ◽

Vol 130 (1) ◽

pp. 69-71 ◽

Cited By ~ 10

Author(s):

Qiqiong Cui ◽

Wei Zhang ◽

Hu Wang ◽

Xin Sun ◽

Huanyi Yang ◽

...

Keyword(s):

Atrial Fibrillation ◽

Paroxysmal Atrial Fibrillation ◽

Right Atrial ◽

Atrial Size ◽

Left And Right

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Changes in left and right atrial size after cardioversion of atrial fibrillation: Role of mitral valve disease

Journal of the American College of Cardiology ◽

10.1016/0735-1097(93)90593-p ◽

1993 ◽

Vol 22 (6) ◽

pp. 1666-1672 ◽

Cited By ~ 66

Author(s):

A.T.Marcel Gosselink ◽

Harry J.G.M. Crijns ◽

Hans P.M. Hamer ◽

Hans Hillege ◽

Kong I. Lie

Keyword(s):

Atrial Fibrillation ◽

Mitral Valve ◽

Mitral Valve Disease ◽

Valve Disease ◽

Right Atrial ◽

Atrial Size ◽

Left And Right

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Gender-specific reference value of urine albumin–creatinine ratio in healthy Chinese adults: Results of the Beijing CKD survey

Clinica Chimica Acta ◽

10.1016/j.cca.2008.09.002 ◽

2008 ◽

Vol 398 (1-2) ◽

pp. 125-129 ◽

Cited By ~ 9

Author(s):

Rong Xu ◽

LuXia Zhang ◽

PuHong Zhang ◽

Fang Wang ◽

Li Zuo ◽

...

Keyword(s):

Reference Value ◽

Specific Reference ◽

Creatinine Ratio ◽

Chinese Adults ◽

Albumin Creatinine Ratio ◽

Urine Albumin ◽

Urine Albumin Creatinine Ratio ◽

Healthy Chinese ◽

Gender Specific

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Prenatal ultrasound diagnosis of pulmonary atresia in combination with left atrial isomerism

10.21516/2413-1458-2017-16-1-66-71 ◽

2017 ◽

Author(s):

M Medvedev, M.V. Kubrina, O.S. Zarubina et all

Keyword(s):

Left Atrial ◽

Reverse Flow ◽

Ductus Arteriosus ◽

Pulmonary Atresia ◽

Prenatal Ultrasound ◽

Ultrasound Diagnosis ◽

Right Atrial ◽

Second Trimester ◽

Left And Right ◽

Atrial Isomerism

Two cases of prenatal ultrasound diagnosis of left atrial isomerism in the second trimester of gestation is presented. These two cases were in combination with pulmonary atresia and right aortic arch. Left atrial isomerism was identify by the digit-like shape of the left and right atrial appendages. The pulmonary atresia was identified on the basis of reverse flow in small pulmonary artery. A right aortic was identified by “U”-shaped confluence of aorta and ductus arteriosus in view of three vessels and trachea. The trachea was located between the vessels. The pregnancies were terminated and prenatal diagnosis was conformed at autopsy

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Reference Values for Left Atrial Strain and Strain Rate Based on a Large Sample of Healthy Chinese Adults: An MR ‐Feature Tracking Study

Journal of Magnetic Resonance Imaging ◽

10.1002/jmri.27768 ◽

2021 ◽

Author(s):

Yiyuan Gao ◽

Zhen Zhang ◽

Gengxiao Li ◽

Shanshan Zhou ◽

Mingwu Lou ◽

...

Keyword(s):

Strain Rate ◽

Reference Values ◽

Left Atrial ◽

Feature Tracking ◽

Chinese Adults ◽

Left Atrial Strain ◽

Large Sample ◽

Strain And Strain Rate ◽

Healthy Chinese ◽

Atrial Strain

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Inducibility, but not stability, of atrial fibrillation is increased by NOX2 overexpression in mice

Cardiovascular Research ◽

10.1093/cvr/cvab019 ◽

2021 ◽

Author(s):

Alexandra S Mighiu ◽

Alice Recalde ◽

Klemen Ziberna ◽

Ricardo Carnicer ◽

Jakub Tomek ◽

...

Keyword(s):

Atrial Fibrillation ◽

Superoxide Production ◽

Right Atrial ◽

Burst Stimulation ◽

Lv Mass ◽

Surface Ecg ◽

Tissue Homogenates ◽

Genotype Difference ◽

Left And Right

Abstract Aims Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial superoxide production. An increase in NOX2 activity accompanies atrial fibrillation (AF) induction and electrical remodelling in animal models and predicts incident AF in humans; however, a direct causal role for NOX2 in AF has not been demonstrated. Accordingly, we investigated whether myocardial NOX2 overexpression in mice (NOX2-Tg) is sufficient to generate a favourable substrate for AF and further assessed the effects of atorvastatin, an inhibitor of NOX2, on atrial superoxide production and AF susceptibility. Methods and results NOX2-Tg mice showed a 2- to 2.5-fold higher atrial protein content of NOX2 compared with wild-type (WT) controls, which was associated with a significant (twofold) increase in NADPH-stimulated superoxide production (2-hydroxyethidium by HPLC) in left and right atrial tissue homogenates (P = 0.004 and P = 0.019, respectively). AF susceptibility assessed in vivo by transoesophageal atrial burst stimulation was modestly increased in NOX2-Tg compared with WT (probability of AF induction: 88% vs. 69%, respectively; P = 0.037), in the absence of significant alterations in AF duration, surface ECG parameters, and LV mass or function. Mechanistic studies did not support a role for NOX2 in promoting electrical or structural remodelling, as high-resolution optical mapping of atrial tissues showed no differences in action potential duration and conduction velocity between genotypes. In addition, we did not observe any genotype difference in markers of fibrosis and inflammation, including atrial collagen content and Col1a1, Il-1β, Il-6, and Mcp-1 mRNA. Similarly, NOX2 overexpression did not have consistent effects on RyR2 Ca2+ leak nor did it affect PKA or CaMKII-mediated RyR2 phosphorylation. Finally, treatment with atorvastatin significantly inhibited atrial superoxide production in NOX2-Tg but had no effect on AF induction in either genotype. Conclusion Together, these data indicate that while atrial NOX2 overexpression may contribute to atrial arrhythmogenesis, NOX2-derived superoxide production does not affect the electrical and structural properties of the atrial myocardium.

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