Simple single-section method for measurement of left and right atrial volumes with electron-beam CT

1999 ◽  
Vol 6 (8) ◽  
pp. 481-486 ◽  
Author(s):  
Matthew J. Budoff ◽  
Songshou Mao ◽  
ShaoJung Wang ◽  
Hamid Bakhsheshi ◽  
Bruce H. Brundage
Author(s):  
M Medvedev, M.V. Kubrina, O.S. Zarubina et all

Two cases of prenatal ultrasound diagnosis of left atrial isomerism in the second trimester of gestation is presented. These two cases were in combination with pulmonary atresia and right aortic arch. Left atrial isomerism was identify by the digit-like shape of the left and right atrial appendages. The pulmonary atresia was identified on the basis of reverse flow in small pulmonary artery. A right aortic was identified by “U”-shaped confluence of aorta and ductus arteriosus in view of three vessels and trachea. The trachea was located between the vessels. The pregnancies were terminated and prenatal diagnosis was conformed at autopsy


2021 ◽  
Author(s):  
Alexandra S Mighiu ◽  
Alice Recalde ◽  
Klemen Ziberna ◽  
Ricardo Carnicer ◽  
Jakub Tomek ◽  
...  

Abstract Aims Gp91-containing NADPH oxidases (NOX2) are a significant source of myocardial superoxide production. An increase in NOX2 activity accompanies atrial fibrillation (AF) induction and electrical remodelling in animal models and predicts incident AF in humans; however, a direct causal role for NOX2 in AF has not been demonstrated. Accordingly, we investigated whether myocardial NOX2 overexpression in mice (NOX2-Tg) is sufficient to generate a favourable substrate for AF and further assessed the effects of atorvastatin, an inhibitor of NOX2, on atrial superoxide production and AF susceptibility. Methods and results NOX2-Tg mice showed a 2- to 2.5-fold higher atrial protein content of NOX2 compared with wild-type (WT) controls, which was associated with a significant (twofold) increase in NADPH-stimulated superoxide production (2-hydroxyethidium by HPLC) in left and right atrial tissue homogenates (P = 0.004 and P = 0.019, respectively). AF susceptibility assessed in vivo by transoesophageal atrial burst stimulation was modestly increased in NOX2-Tg compared with WT (probability of AF induction: 88% vs. 69%, respectively; P = 0.037), in the absence of significant alterations in AF duration, surface ECG parameters, and LV mass or function. Mechanistic studies did not support a role for NOX2 in promoting electrical or structural remodelling, as high-resolution optical mapping of atrial tissues showed no differences in action potential duration and conduction velocity between genotypes. In addition, we did not observe any genotype difference in markers of fibrosis and inflammation, including atrial collagen content and Col1a1, Il-1β, Il-6, and Mcp-1 mRNA. Similarly, NOX2 overexpression did not have consistent effects on RyR2 Ca2+ leak nor did it affect PKA or CaMKII-mediated RyR2 phosphorylation. Finally, treatment with atorvastatin significantly inhibited atrial superoxide production in NOX2-Tg but had no effect on AF induction in either genotype. Conclusion Together, these data indicate that while atrial NOX2 overexpression may contribute to atrial arrhythmogenesis, NOX2-derived superoxide production does not affect the electrical and structural properties of the atrial myocardium.


1997 ◽  
Vol 70 (837) ◽  
pp. 964-966 ◽  
Author(s):  
M Takahashi ◽  
K Murata ◽  
M Yamori ◽  
M Okuno ◽  
M Nakagawa ◽  
...  

1999 ◽  
Vol 6 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Lloyd E. Greaser ◽  
Hyo-Chun Yoon ◽  
Richard T. Mather ◽  
Michael McNitt-Gray ◽  
Jonathan G. Goldin

2002 ◽  
Vol 93 (2) ◽  
pp. 660-666 ◽  
Author(s):  
Inéz Frerichs ◽  
José Hinz ◽  
Peter Herrmann ◽  
Gerald Weisser ◽  
Günter Hahn ◽  
...  

The aim of the study was to validate the ability of electrical impedance tomography (EIT) to detect local changes in air content, resulting from modified ventilator settings, by comparing EIT findings with electron beam computed tomography (EBCT) scans obtained under identical steady-state conditions. The experiments were carried out on six anesthetized supine pigs ventilated with five tidal volumes (Vt) at three positive end-expiratory pressure (PEEP) levels. The lung air content changes were determined both by EIT (Goe-MF1 system) and EBCT (Imatron C-150XP scanner) in six regions of interest, located in the ventral, middle, and dorsal areas of each lung, with respect to the reference air content at the lowest Vt and PEEP, as a change in either local electrical impedance or lung tissue density. An increase in local air content with Vt and PEEP was identified by both methods at all regions studied. A good correlation between the changes in lung air content determined by EIT and EBCT was revealed. Mean correlation coefficients in the ventral, middle, and dorsal regions were 0.81, 0.87, and 0.93, respectively. The study confirms that EIT is a suitable, noninvasive method for detecting regional changes in air content and monitoring local effects of artificial ventilation.


2000 ◽  
Vol 7 (11) ◽  
pp. 927-933 ◽  
Author(s):  
Bin Lu ◽  
Ruping Dai ◽  
Hua Bai ◽  
Sha He ◽  
ShiLiang Jiang ◽  
...  

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 712-712
Author(s):  
Martin G Rodriguez-Porcel ◽  
James D Krier ◽  
Amir Lerman ◽  
Juan C Romero ◽  
Lilach O Lerman

P105 The kidney is a target organ for cardiovascular risk factors, such as atherosclerosis and hypertension (HT), and is particularly susceptible to their combination. Even at an early stage, hypercholesterolemia (HC) and HT are individually associated with impaired renal perfusion responses to challenge with vasodilators. However, the effect of combined HC and HT on renal perfusion remains uncertain. To examine this, regional renal perfusion response to the renal vasodilator acetylcholine (Ach) was quantified in 4 groups of pigs, using electron beam CT, after 12 weeks of either normal (n=6), HC diet (n=6), HT (unilateral renal artery stenosis, n=5), or combined HC and HT (HC+HT, n=6). The HC and HC+HT groups had increased cholesterol levels vs. normal and HT (430±82 and 351±52 vs. 71±6 and 83±4 mg/dl, ANOVA p<0.05, respectively). Mean arterial pressure was significantly elevated in HT and HC+HT vs. normal and HC (132±6 and 127±13 vs. 88±5 and 92±6 mmHg, p<0.05, respectively). The combination of HC and HT was associated with a greater impairment in cortical and papillary perfusion responses than HC or HT alone (Table). Medullary perfusion response was not significantly different among the four groups (Table). These results demonstrate that concurrent HC and HT have a greater detrimental effect on renal perfusion responses than HC or HT alone, and that this effect is regionally heterogeneous. These effects may potentially lead to enhanced renal functional impairment and may play a role in the progression of renal damage in HT and atherosclerosis.


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