scholarly journals On-chip coherent detection with quantum limited sensitivity

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Vadim Kovalyuk ◽  
Simone Ferrari ◽  
Oliver Kahl ◽  
Alexander Semenov ◽  
Michael Shcherbatenko ◽  
...  
Author(s):  
Alex Chow ◽  
Ron Ho ◽  
David Hopkins ◽  
Darko Popovic

2021 ◽  
Author(s):  
Yong Geng ◽  
Heng Zhou ◽  
Xinjie Han ◽  
Wenwen Cui ◽  
Qiang Zhang ◽  
...  

Abstract Dissipative Kerr soliton microcomb has been recognized as a promising on-chip multi-wavelength laser source for fiber optical communications, as its comb lines possess frequency and phase stability far beyond the independent lasers. In the scenarios of coherent optical transmission and interconnect, a highly beneficial but rarely explored target is to re-generate a Kerr soliton microcomb at the receiver side as local oscillators that conserve the frequency and phase property of the incoming data carriers, so that to enable coherent detection with minimized optical and electrical compensations. Here, by using the techniques of pump laser conveying and two-point locking, we implement re-generation of a Kerr soliton microcomb that faithfully clones the frequency and phase coherence of another microcomb sent from 50 km away. Moreover, leveraging the coherence-cloned soliton microcombs as carriers and local oscillators, we demonstrate terabit coherent data interconnect, wherein traditional digital processes for frequency offset estimation is totally dispensed with, and carrier phase estimation is substantially simplified via slowed-down phase estimation rate per channel and joint phase estimation among multiple channels. Our work reveals that, in addition to providing a multitude of laser tones, regulating the frequency and phase of Kerr soliton microcombs among transmitters and receivers can significantly improve optical coherent communication in terms of performance, power consumption, and simplicity.


Author(s):  
Deming Kong ◽  
Yong Liu ◽  
Zhengqi Ren ◽  
Yongmin Jung ◽  
Minhao Pu ◽  
...  

Author(s):  
Chuanshi Yang ◽  
Zesheng Zheng ◽  
Zhongyuan Fang ◽  
Xiaoyan Tang ◽  
Kai Tang ◽  
...  

2020 ◽  
Vol 477 (14) ◽  
pp. 2679-2696
Author(s):  
Riddhi Trivedi ◽  
Kalyani Barve

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.


VASA ◽  
2016 ◽  
Vol 45 (2) ◽  
pp. 149-154 ◽  
Author(s):  
Jie Li ◽  
Lei Feng ◽  
Jiangbo Li ◽  
Jian Tang

Abstract. Background: The aim of this meta-analysis was to evaluate the diagnostic accuracy of magnetic resonance angiography (MRA) for acute pulmonary embolism (PE). Methods: A systematic literature search was conducted that included studies from January 2000 to August 2015 using the electronic databases PubMed, Embase and Springer link. The summary receiver operating characteristic (SROC) curve, sensitivity, specificity, positive likelihood ratios (PLR), negative likelihood ratios (NLR), and diagnostic odds ratio (DOR) as well as the 95 % confidence intervals (CIs) were calculated to evaluate the diagnostic accuracy of MRA for acute PE. Meta-disc software version 1.4 was used to analyze the data. Results: Five studies were included in this meta-analysis. The pooled sensitivity (86 %, 95 % CI: 81 % to 90 %) and specificity (99 %, 95 % CI: 98 % to 100 %) demonstrated that MRA diagnosis had limited sensitivity and high specificity in the detection of acute PE. The pooled estimate of PLR (41.64, 95 % CI: 17.97 to 96.48) and NLR (0.17, 95 % CI: 0.11 to 0.27) provided evidence for the low missed diagnosis and misdiagnosis rates of MRA for acute PE. The high diagnostic accuracy of MRA for acute PE was demonstrated by the overall DOR (456.51, 95 % CI: 178.38 - 1168.31) and SROC curves (AUC = 0.9902 ± 0.0061). Conclusions: MRA can be used for the diagnosis of acute PE. However, due to limited sensitivity, MRA cannot be used as a stand-alone test to exclude acute PE.


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