scholarly journals Food Protective Effects of 3-Methylbenzaldehyde Derived from Myosotis arvensis and Its Analogues against Tyrophagus putrescentiae

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Jun-Hwan Park ◽  
Na-Hyun Lee ◽  
Young-Cheol Yang ◽  
Hoi-Seon Lee
2013 ◽  
Vol 76 (11) ◽  
pp. 1887-1891
Author(s):  
MIN-GI KIM ◽  
JU-HYUN JEON ◽  
HOI-SEON LEE

The acaricidal effects of the active constituent isolated from Ostericum praeteritum oil and its derivatives were compared with that of benzyl benzoate using fumigant and contact toxicity bioassays against Tyrophagus putrescentiae mites. The active compound of O. praeteritum was isolated by various chromatographic techniques and was identified as 3-methylphenol (C7H8O). On the basis of 50% lethal dose values, 3-methylphenol (1.42 μg/cm2) was determined to be 9.18 times more effective than benzyl benzoate (13.04 μg/cm2), followed by 6-fluoro-3-methylphenol (2.18 μg/cm2), 4-isopropyl-3-methylphenol (2.53 μg/cm2), and 6-chloro-3-methylphenol (4.03 μg/cm2), against Tyrophagus putrescentiae mites in the fumigant bioassay. In the contact toxicity bioassay, 3-methylphenol (1.03 μg/cm2) was the most-toxic compound against T. putrescentiae mites, followed by 6-fluoro-3-methylphenol (2.09 μg/cm2), 4-isopropyl-3-methylphenol (2.11 μg/cm2), 6-chloro-3-methylphenol (3.78 μg/cm2), and benzyl benzoate (10.33 μg/cm2). These results indicate that the introduction of chloro, isopropyl, and fluoro functional groups to the 3-methylphenol skeleton increased the acaricidal activity. Therefore, 3-methylphenol and its derivatives could potentially be used as natural acaricides against T. purescentiae.


Author(s):  
Paulina Iwan ◽  
Jan Stepniak ◽  
Malgorzata Karbownik-Lewinska

Abstract. Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9 mM. Either potassium iodide (KI) or potassium iodate (KIO3) are used in iodine prophylaxis. KI is confirmed as absolutely safe. KIO3 possesses chemical properties suggesting its potential toxicity. Melatonin (N-acetyl-5-methoxytryptamine) is an effective antioxidant and free radical scavenger. Study aims: to evaluate potential protective effects of melatonin against oxidative damage to membrane lipids (lipid peroxidation, LPO) induced by KI or KIO3 in porcine thyroid. Homogenates of twenty four (24) thyroids were incubated in presence of either KI or KIO3 without/with melatonin (5 mM). As melatonin was not effective against KI-induced LPO, in the next step only KIO3 was used. Homogenates were incubated in presence of KIO3 (200; 100; 50; 25; 20; 15; 10; 7.5; 5.0; 2.5; 1.25 mM) without/with melatonin or 17ß-estradiol. Five experiments were performed with different concentrations of melatonin (5.0; 2.5; 1.25; 1.0; 0.625 mM) and one with 17ß-estradiol (1.0 mM). Malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) concentration (LPO index) was measured spectrophotometrically. KIO3 increased LPO with the strongest damaging effect (MDA + 4-HDA level: ≈1.28 nmol/mg protein, p < 0.05) revealed at concentrations of around 15 mM, thus corresponding to physiological iodine concentrations in the thyroid. Melatonin reduced LPO (MDA + 4-HDA levels: from ≈0.97 to ≈0,76 and from ≈0,64 to ≈0,49 nmol/mg protein, p < 0.05) induced by KIO3 at concentrations of 10 mM or 7.5 mM. Conclusion: Melatonin can reduce very strong oxidative damage to membrane lipids caused by KIO3 used in doses resulting in physiological iodine concentrations in the thyroid.


2009 ◽  
Author(s):  
Phillip A. Ianni ◽  
Kenneth E. Hart ◽  
Stephen Hibbard ◽  
Michelle Carroll ◽  
Tobi Wilson ◽  
...  

2009 ◽  
Author(s):  
Pauline Garcia-Reid ◽  
Christina Hamme Peterson ◽  
Robert James Reid ◽  
Paul W. Speer ◽  
N. Andrew Peterson

2001 ◽  
Vol 11 (4) ◽  
pp. 183-193 ◽  
Author(s):  
Tedine Ranich ◽  
Sam J. Bhathena ◽  
Manuel T. Velasquez

2011 ◽  
Vol 49 (10) ◽  
Author(s):  
Lena John ◽  
Anja Fromm ◽  
Michael Fromm ◽  
Jörg-Dieter Schulzke ◽  
Maren Amasheh

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