Topography of emotional valence and arousal within the motor part of the subthalamic nucleus in Parkinson’s disease

AbstractClinical motor and non-motor effects of deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson's disease (PD) seem to depend on the stimulation site within the STN. We analysed the effects of the position of the stimulation electrode within the motor STN on subjective emotional experience, expressed as emotional valence and arousal ratings to pictures representing primary rewards and aversive fearful stimuli in 20 PD patients. Patients’ ratings from both aversive and erotic stimuli matched the mean ratings from a group of 20 control subjects at similar position within the STN. Patients with electrodes located more posteriorly reported both valence and arousal ratings from both the rewarding and aversive pictures as more extreme. Moreover, posterior electrode positions were associated with a higher occurrence of depression at a long-term follow-up. This brain–behavior relationship suggests a complex emotion topography in the motor part of the STN. Both valence and arousal representations overlapped and were uniformly arranged anterior-posteriorly in a gradient-like manner, suggesting a specific spatial organization needed for the coding of the motivational salience of the stimuli. This finding is relevant for our understanding of neuropsychiatric side effects in STN DBS and potentially for optimal electrode placement.

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EP 45. Emotional valence and arousal gradient along the anterior–posterior axis within the subthalamic nucleus in Parkinson’s disease

Clinical Neurophysiology ◽

10.1016/j.clinph.2016.05.237 ◽

2016 ◽

Vol 127 (9) ◽

pp. e194-e195

Author(s):

T. Serranova ◽

T. Sieger ◽

F. Růžička ◽

P. Dušek ◽

P. Vostatek ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Subthalamic Nucleus ◽

Emotional Valence ◽

Valence And Arousal ◽

Anterior Posterior ◽

Anterior Posterior Axis

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Median Nerve Stimulation Facilitates the Identification of Somatotopy of the Subthalamic Nucleus in Parkinson’s Disease Patients under Inhalational Anesthesia

Biomedicines ◽

10.3390/biomedicines10010074 ◽

2021 ◽

Vol 10 (1) ◽

pp. 74

Author(s):

Yu-Chen Chen ◽

Chang-Chih Kuo ◽

Shin-Yuan Chen ◽

Tsung-Ying Chen ◽

Yan-Hong Pan ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Median Nerve ◽

Subthalamic Nucleus ◽

Nerve Stimulation ◽

Electrode Placement ◽

Beta Band ◽

Inhalational Anesthesia ◽

Median Nerve Stimulation ◽

Power Spectral

Deep brain stimulation (DBS) improves Parkinson’s disease (PD) symptoms by suppressing neuropathological oscillations. These oscillations are also modulated by inhalational anesthetics used during DBS surgery in some patients, influencing electrode placement accuracy. We sought to evaluate a method that could avoid these effects. We recorded subthalamic nucleus (STN) neuronal firings in 11 PD patients undergoing DBS under inhalational anesthesia. Microelectrode recording (MER) during DBS was collected under median nerve stimulation (MNS) delivered at 5, 20, and 90 Hz frequencies and without MNS. We analyzed the spike firing rate and neuronal activity with power spectral density (PSD), and assessed correlations between the neuronal oscillation parameters and clinical motor outcomes. No patient experienced adverse effects during or after DBS surgery. PSD analysis revealed that peripheral 20 Hz MNS produced significant differences in the dorsal and ventral subthalamic nucleus (STN) between the beta band oscillation (16.9 ± 7.0% versus 13.5 ± 4.8%, respectively) and gamma band oscillation (56.0 ± 13.7% versus 66.3 ± 9.4%, respectively) (p < 0.05). Moreover, 20-Hz MNS entrained neural oscillation over the dorsal STN, which correlated positively with motor disabilities. MNS allowed localization of the sensorimotor STN and identified neural characteristics under inhalational anesthesia. This paradigm may help identify an alternative method to facilitate STN identification and DBS surgery under inhalational anesthesia.

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Non-motor effects of deep brain stimulation of the subthalamic nucleus in Parkinson's disease: preliminary physiological results

Neurological Sciences ◽

10.1007/s100720170059 ◽

2001 ◽

Vol 22 (1) ◽

pp. 85-86 ◽

Cited By ~ 28

Author(s):

A. Priori ◽

C. Cinnante ◽

S. Genitrini ◽

A. Pesenti ◽

G. Tortora ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Deep Brain Stimulation ◽

Subthalamic Nucleus ◽

Brain Stimulation ◽

Motor Effects ◽

Deep Brain ◽

Stimulation Of

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Subthalamic nucleus stimulation in Parkinson's disease: Postoperative CT–MRI fusion images confirm accuracy of electrode placement using intraoperative multi-unit recording

Neurophysiologie Clinique ◽

10.1016/j.neucli.2007.09.005 ◽

2007 ◽

Vol 37 (6) ◽

pp. 457-466 ◽

Cited By ~ 25

Author(s):

M. Shin ◽

J.-P. Lefaucheur ◽

M.F. Penholate ◽

P. Brugières ◽

J.-M. Gurruchaga ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Subthalamic Nucleus ◽

Electrode Placement ◽

Unit Recording ◽

Subthalamic Nucleus Stimulation ◽

Fusion Images

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Subthalamic nucleus stimulation affects subjective emotional experience in Parkinson's disease patients

Neuropsychologia ◽

10.1016/j.neuropsychologia.2009.03.003 ◽

2009 ◽

Vol 47 (8-9) ◽

pp. 1928-1937 ◽

Cited By ~ 36

Author(s):

Siobhan Vicente ◽

Isabelle Biseul ◽

Julie Péron ◽

Pierre Philippot ◽

Sophie Drapier ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Subthalamic Nucleus ◽

Emotional Experience ◽

Subthalamic Nucleus Stimulation

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A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease

Parkinson s Disease ◽

10.4061/2011/742907 ◽

2011 ◽

Vol 2011 ◽

pp. 1-10

Author(s):

Sunsern Limsoontarakul ◽

Meghan C. Campbell ◽

Kevin J. Black

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Temporal Stability ◽

Cingulate Cortex ◽

Emotional Valence ◽

Brain Regions ◽

Posterior Cingulate Cortex ◽

Perfusion Mri ◽

Medial Pfc ◽

Valence And Arousal

Background. Brain regions subserving emotion have mostly been studied using functional magnetic resonance imaging (fMRI) during emotion provocation procedures in healthy participants.Objective. To identify neuroanatomical regions associated with spontaneous changes in emotional state over time.Methods. Self-rated emotional valence and arousal scores, and regional cerebral blood flow (rCBF) measured by perfusion MRI, were measured 4 or 8 times spanning at least 2 weeks in each of 21 subjects with Parkinson’s disease (PD). A random-effects SPM analysis, corrected for multiple comparisons, identified significant clusters of contiguous voxels in which rCBF varied with valence or arousal.Results. Emotional valence correlated positively with rCBF in several brain regions, including medial globus pallidus, orbital prefrontal cortex (PFC), and white matter near putamen, thalamus, insula, and medial PFC. Valence correlated negatively with rCBF in striatum, subgenual cingulate cortex, ventrolateral PFC, and precuneus—posterior cingulate cortex (PCC). Arousal correlated positively with rCBF in clusters including claustrum-thalamus-ventral striatum and inferior parietal lobule and correlated negatively in clusters including posterior insula—mediodorsal thalamus and midbrain.Conclusion. This study demonstrates that the temporal stability of perfusion MRI allows within-subject investigations of spontaneous fluctuations in mental state, such as mood, over relatively long-time intervals.

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Gaps and roadmap of novel neuromodulation targets for treatment of gait in Parkinson’s disease

npj Parkinson s Disease ◽

10.1038/s41531-021-00276-6 ◽

2022 ◽

Vol 8 (1) ◽

Author(s):

Rubens Gisbert Cury ◽

Nicola Pavese ◽

Tipu Z. Aziz ◽

Joachim K. Krauss ◽

Elena Moro ◽

...

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Globus Pallidus ◽

Subthalamic Nucleus ◽

Pedunculopontine Nucleus ◽

Globus Pallidus Internus ◽

Electrode Placement ◽

Optimal Programming ◽

Cortical Regions ◽

Oscillation Dynamics

AbstractGait issues in Parkinson’s disease (PD) are common and can be highly disabling. Although levodopa and deep brain stimulation (DBS) of the subthalamic nucleus and the globus pallidus internus have been established therapies for addressing the motor symptoms of PD, their effects on gait are less predictable and not well sustained with disease progression. Given the high prevalence of gait impairment in PD and the limitations in currently approved therapies, there has been considerable interest in alternative neuromodulation targets and techniques. These have included DBS of pedunculopontine nucleus and substantia nigra pars reticulata, spinal cord stimulation, non-invasive modulation of cortical regions and, more recently, vagus nerve stimulation. However, successes and failures have also emerged with these approaches. Current gaps and controversies are related to patient selection, optimal electrode placement within the target, placebo effects and the optimal programming parameters. Additionally, recent advances in pathophysiology of oscillation dynamics have driven new models of closed-loop DBS systems that may or may not be applicable to gait issues. Our aim is to describe approaches, especially neuromodulation procedures, and emerging challenges to address PD gait issues beyond subthalamic nucleus and the globus pallidus internus stimulation.

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