scholarly journals The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sophie Fletcher ◽  
Helen Maddock ◽  
Rob S. James ◽  
Rob Wallis ◽  
Mayel Gharanei
Keyword(s):  
In Vitro Model ◽  
Papillary Muscles ◽  
Cardiac Work ◽  
Drug Induced ◽  
Loop Technique ◽  
Vitro Model ◽  
Induced Changes ◽  
Work Loop

The cardiac work-loop technique to assess drug-induced changes in cardiac contractility

2019 ◽  
Vol 99 ◽  
pp. 106595
Author(s):  
Sophie Fletcher ◽  
Rob James ◽  
Rob Wallis ◽  
Helen Maddock ◽  
Mayel Gharanei
Keyword(s):  
Cardiac Contractility ◽  
Cardiac Work ◽  
Drug Induced ◽  
Loop Technique ◽  
Induced Changes ◽  
Work Loop

Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis

2008 ◽  
Vol 54 (2) ◽  
pp. 428-437 ◽  
Author(s):  
F. Matrisciano ◽  
M. Zusso ◽  
I. Panaccione ◽  
B. Turriziani ◽  
A. Caruso ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
In Vitro Model ◽  
Antidepressant Drug ◽  
Drug Induced ◽  
Vitro Model

scholarly journals Porcine hepatocytes culture on biofunctionalized 3D inverted colloidal crystal scaffolds as an in vitro model for predicting drug hepatotoxicity

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 17995-18007 ◽  
Author(s):  
Lingyan Wu ◽  
Gaia Ferracci ◽  
Yan Wang ◽  
Teng Fei Fan ◽  
Nam-Joon Cho ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Colloidal Crystal ◽  
Three Dimensional ◽  
Drug Induced ◽  
Attrition Rates ◽  
Common Causes ◽  
Vitro Model ◽  
Colloidal Crystal Scaffolds

As drug-induced hepatotoxicity represents one of the most common causes of drug failure, three-dimensional in vitro liver platforms represent a fantastic toolbox to predict drug toxicity and reduce in vivo studies and drug attrition rates.

Novel in vitro model captures drug-induced inflammation as a mechanism contributing to hepatotoxicity

2021 ◽  
Vol 350 ◽  
pp. S59
Author(s):  
F. Tasnim ◽  
X. Huang ◽  
Y.T. Soong ◽  
H. Yu
Keyword(s):  
In Vitro Model ◽  
Drug Induced ◽  
Vitro Model

scholarly journals Co-culture of Hepatocytes and Kupffer Cells as an In Vitro Model of Inflammation and Drug-Induced Hepatotoxicity

2016 ◽  
Vol 105 (2) ◽  
pp. 950-964 ◽  
Author(s):  
Kelly A. Rose ◽  
Natalie S. Holman ◽  
Angela M. Green ◽  
Melvin E. Andersen ◽  
Edward L. LeCluyse
Keyword(s):  
Kupffer Cells ◽  
In Vitro Model ◽  
Drug Induced ◽  
Vitro Model ◽  
Culture Of Hepatocytes

An in vitro model for assessment of drug-induced torsade de pointes arrhythmia

2008 ◽  
Vol 378 (6) ◽  
pp. 631-644 ◽  
Author(s):  
Stefan Dhein ◽  
Franziska Perlitz ◽  
Friedrich-Wilhelm Mohr
Keyword(s):  
In Vitro Model ◽  
Torsade De Pointes ◽  
Drug Induced ◽  
Vitro Model
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