The cardiac work-loop technique to assess drug-induced changes in cardiac contractility

2019 ◽  
Vol 99 ◽  
pp. 106595
Author(s):  
Sophie Fletcher ◽  
Rob James ◽  
Rob Wallis ◽  
Helen Maddock ◽  
Mayel Gharanei
Keyword(s):  
Cardiac Contractility ◽  
Cardiac Work ◽  
Drug Induced ◽  
Loop Technique ◽  
Induced Changes ◽  
Work Loop

An in vitro platform using the human and rat primary cardiomyocyte work loop assay to screen for drug-induced effects on cardiac contractility

2020 ◽  
Vol 105 ◽  
pp. 106759
Author(s):  
Mayel Gharanei ◽  
Jeremy Billson ◽  
Oana Blair ◽  
Josh Hurst ◽  
Adam Linekar ◽  
...  
Keyword(s):  
Cardiac Contractility ◽  
Drug Induced ◽  
Work Loop

Drug Induced Changes in Cell Organelles

1968 ◽  
Vol 26 ◽  
pp. 110-111
Author(s):  
Sarah A. Luse
Keyword(s):  
Clinical Medicine ◽  
Cell Organelles ◽  
Riboflavin Deficiency ◽  
Drug Induced ◽  
New Era ◽  
Health And Disease ◽  
In The Beginning ◽  
Cellular Pathology ◽  
Induced Changes ◽  
The Impact

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.

Drug induced changes in free, labile and stable acetylcholine of guinea-pig brain

1969 ◽  
Vol 18 (6) ◽  
pp. 1315-1324 ◽  
Author(s):  
L. Beani ◽  
C. Bianchi ◽  
P. Megazzini ◽  
L. Ballotti ◽  
G. Bernardi
Keyword(s):  
Guinea Pig ◽  
Drug Induced ◽  
Pig Brain ◽  
Induced Changes ◽  
Guinea Pig Brain

scholarly journals Dynamic Proteomics Reveals High Plasticity of Cellular Proteome: Growth-Related and Drug-Induced Changes in Cancer Cells are Comparable

PROTEOMICS ◽  
2018 ◽  
Vol 18 (24) ◽  
pp. 1800118 ◽  
Author(s):  
Pierre Sabatier ◽  
Amir Ata Saei ◽  
Shiyu Wang ◽  
Roman A. Zubarev
Keyword(s):  
Cancer Cells ◽  
High Plasticity ◽  
Drug Induced ◽  
Induced Changes
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