Relative fat mass at baseline and its early change may be a predictor of incident nonalcoholic fatty liver disease

Abstract The relationship between changes in body components and the risk of nonalcoholic fatty liver disease (NAFLD) is not fully understood. We investigated the effects of body components and subsequent changes on incident NAFLD at follow-up ultrasound scanning in a longitudinal cohort. We included 9967 participants without NAFLD at baseline who underwent serial health examinations. Sex-specific, weight-adjusted skeletal muscle index (SMI_Wt) was used. Mean follow-up duration was 48.5 ± 33.5 months. NAFLD developed in 2395 participants (24.0%). Body composition was measured using bioelectrical impedance analysis. The following baseline body components were significantly associated with incident NAFLD: the lowest and middle SMI_Wt tertiles in the normal-weight group (adjusted hazard ratio [aHR] = 2.20 and 1.54, respectively), and fat percentage in the normal-weight (aHR = 1.12), overweight (aHR = 1.05), and obese groups (aHR = 1.03) (all P < 0.05). Among 5,033 participants who underwent ≥ 3 health examinations, SMI_Wt increase between the first and second examinations was an independent protective factor against incident NAFLD in non-obese groups (P < 0.05). Increased fat percentage was an independent risk factor for incident NAFLD in all weight categories (P < 0.05). High fat mass at baseline may be a better predictor of incident NAFLD than muscle mass. Reciprocal changes in fat and muscle mass during the first year of follow-up predicted incident NAFLD in non-obese groups.

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Prevalence of nonalcoholic fatty liver disease in normal-weight and overweight preadolescent children in Haryana, India

Indian Pediatrics ◽

10.1007/s13312-017-1202-3 ◽

2017 ◽

Vol 54 (12) ◽

pp. 1012-1016 ◽

Cited By ~ 3

Author(s):

Manoja Kumar Das ◽

Vidyut Bhatia ◽

Anupam Sibal ◽

Abha Gupta ◽

Sarath Gopalan ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Normal Weight ◽

Nonalcoholic Fatty Liver ◽

Preadolescent Children

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The association between white blood cell subtypes and prevalence and incidence of nonalcoholic fatty liver disease

European Journal of Inflammation ◽

10.1177/2058739219834477 ◽

2019 ◽

Vol 17 ◽

pp. 205873921983447

Author(s):

Hongmei Zhang ◽

Yixin Niu ◽

Hongxia Gu ◽

Shuai Lu ◽

Weikang Su ◽

...

Keyword(s):

Liver Disease ◽

Blood Cell ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

White Blood Cell ◽

Fatty Liver Disease ◽

Complete Information ◽

Nonalcoholic Fatty Liver ◽

Independent Risk Factors

The association between white blood cell (WBC) and nonalcoholic fatty liver disease (NAFLD) has been studied before, but whether different WBC subtypes were related to NAFLD was not detailed. The aim of our study was to investigate the relationship between WBC subtypes and NAFLD cross-sectionally and prospectively. The detailed research design has been described previously. At baseline, there were 9930 participants who had complete information, in the end a total of 8079 participants (2588 men and 5491 women) were eventually included in this study. Hepatic ultrasound examination was performed on each participant at baseline and at the end of follow-up. Alcohol abuse and hepatitis were excluded. WBC subtypes and other serum indices were measured at baseline. We found that the total WBC, neutrophil, and lymphocyte counts were independently associated with the prevalence and incidence of NAFLD. After multiple adjustments for age, gender, body mass index (BMI), insulin, HOMA-IR, TG, TC, LDL, and HDL, increased odds ratios (ORs) for new onset NAFLD were observed from the 1st to the 4th quartiles of WBC, neutrophil, and lymphocyte (all P < 0.001 for trend). In conclusion, total WBC counts, neutrophils, and lymphocytes were all independent risk factors for NAFLD in the rural Chinese population. The association was independent of insulin resistance.

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Nonalcoholic Fatty Liver Disease Is Associated With Low Skeletal Muscle Mass in Overweight/Obese Youths

Frontiers in Pediatrics ◽

10.3389/fped.2020.00158 ◽

2020 ◽

Vol 8 ◽

Cited By ~ 1

Author(s):

Lucia Pacifico ◽

Francesco Massimo Perla ◽

Gianmarco Andreoli ◽

Rosangela Grieco ◽

Pasquale Pierimarchi ◽

...

Keyword(s):

Skeletal Muscle ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Muscle Mass ◽

Fatty Liver Disease ◽

Skeletal Muscle Mass ◽

Nonalcoholic Fatty Liver

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Hepatic transcriptome signatures in patients with varying degrees of nonalcoholic fatty liver disease compared with healthy normal-weight individuals

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00358.2018 ◽

2019 ◽

Vol 316 (4) ◽

pp. G462-G472 ◽

Cited By ~ 19

Author(s):

Malte P. Suppli ◽

Kristoffer T. G. Rigbolt ◽

Sanne S. Veidal ◽

Sara Heebøll ◽

Peter Lykke Eriksen ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Nonalcoholic Steatohepatitis ◽

Fatty Liver Disease ◽

Normal Weight ◽

Histological Techniques ◽

Nonalcoholic Fatty Liver ◽

The Metabolic Syndrome ◽

Hepatic Transcriptome

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of conditions ranging from simple steatosis (NAFL), over nonalcoholic steatohepatitis (NASH) with or without fibrosis, to cirrhosis with end-stage disease. The hepatic molecular events underlying the development of NAFLD and transition to NASH are poorly understood. The present study aimed to determine hepatic transcriptome dynamics in patients with NAFL or NASH compared with healthy normal-weight and obese individuals. RNA sequencing and quantitative histomorphometry of liver fat, inflammation and fibrosis were performed on liver biopsies obtained from healthy normal-weight ( n = 14) and obese ( n = 12) individuals, NAFL ( n = 15) and NASH ( n = 16) patients. Normal-weight and obese subjects showed normal liver histology and comparable gene expression profiles. Liver transcriptome signatures were largely overlapping in NAFL and NASH patients, however, clearly separated from healthy normal-weight and obese controls. Most marked pathway perturbations identified in both NAFL and NASH were associated with markers of lipid metabolism, immunomodulation, extracellular matrix remodeling, and cell cycle control. Interestingly, NASH patients with positive Sonic hedgehog hepatocyte staining showed distinct transcriptome and histomorphometric changes compared with NAFL. In conclusion, application of immunohistochemical markers of hepatocyte injury may serve as a more objective tool for distinguishing NASH from NAFL, facilitating improved resolution of hepatic molecular changes associated with progression of NAFLD. NEW & NOTEWORTHY Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries. NAFLD is associated with the metabolic syndrome and can progress to the more serious form, nonalcoholic steatohepatitis (NASH), and ultimately lead to irreversible liver damage. Using gold standard molecular and histological techniques, this study demonstrates that the currently used diagnostic tools are problematic for differentiating mild NAFLD from NASH and emphasizes the marked need for developing improved histological markers of NAFLD progression.

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Natural history of nonalcoholic fatty liver disease: A prospective follow‐up study with serial biopsies

Hepatology Communications ◽

10.1002/hep4.1134 ◽

2017 ◽

Vol 2 (2) ◽

pp. 199-210 ◽

Cited By ~ 34

Author(s):

Patrik Nasr ◽

Simone Ignatova ◽

Stergios Kechagias ◽

Mattias Ekstedt

Keyword(s):

Liver Disease ◽

Natural History ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Nonalcoholic Fatty Liver ◽

Follow Up Study ◽

History Of

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The Impact of Weight Changes on Nonalcoholic Fatty Liver Disease in Adult Men with Normal Weight

Korean Journal of Family Medicine ◽

10.4082/kjfm.2014.35.5.243 ◽

2014 ◽

Vol 35 (5) ◽

pp. 243 ◽

Cited By ~ 8

Author(s):

Ji-Young Cho ◽

Tae-Heum Chung ◽

Kyoung-Mo Lim ◽

Hee-Jin Park ◽

Jung-Mi Jang

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Normal Weight ◽

Weight Changes ◽

Nonalcoholic Fatty Liver ◽

Adult Men ◽

The Impact

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Nonalcoholic fatty liver disease without obesity: the problem to be solved

Terapevticheskii arkhiv ◽

10.17116/terarkh20178912226-232 ◽

2017 ◽

Vol 89 (12-2) ◽

pp. 226-232

Author(s):

A O Bueverov ◽

P O Bogomolov

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Fatty Liver Disease ◽

Lifestyle Modification ◽

Regulatory Element ◽

Normal Weight ◽

Atherogenic Dyslipidemia ◽

Nonalcoholic Fatty Liver ◽

Genes Encoding

It is generally agreed that nonalcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome and is frequently associated with obesity, type 2 diabetes mellitus, atherogenic dyslipidemia, and other components of the syndrome. However, there is no doubt that not all overweight people develop NAFLD and, conversely, the latter may be present in normal weight individuals. The prevalence of NAFLD without obesity in different countries is very variable from 3 to 30%. Its risk factors are considered to be both exogenous (for example, excess intakes of cholesterol and rapidly assimilable fructose) and genetically determined (allelic variants of the genes encoding adiponutrin, the cholesteryl ester transport protein, sterol-regulatory element-binding protein 2). The methods for the diagnosis of NAFLD without obesity do not differ in essence from those for classic NAFLD. Analysis of the conducted investigations gives grounds to claim that lifestyle modification as exercises and dietary restrictions improves biochemical parameters and histological pattern. The efficiency of drug treatments needs further investigation.

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Relationship Between Nonalcoholic Fatty Liver Disease and Low Skeletal Muscle Mass in Obese Youth

Journal of Health, Sports, and Kinesiology - JOHSK ◽

10.47544/johsk.2021.2.2.35 ◽

2021 ◽

Vol 2 (2) ◽

pp. 35-39

Author(s):

David Silas ◽

Jeremy Park ◽

Joon Young Kim

Keyword(s):

Skeletal Muscle ◽

Metabolic Syndrome ◽

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Muscle Mass ◽

Fatty Liver Disease ◽

Skeletal Muscle Mass ◽

Nonalcoholic Fatty Liver ◽

Obese Youth

Previous studies in adults have found a correlation between nonalcoholic fatty liver disease (NAFLD) and sarcopenia. The present study evaluated the relationship between NFALD and skeletal muscle mass in overweight/obese youth. A total of 234 children and adolescents (age 8-16) was stratified into tertiles based on relative muscle mass (RMM). Total, regional lean body mass, and total fat mass were obtained by dual-energy X-ray absorptiometry. RMM was defined as the percent of muscle mass (kg) relative to the sum of muscle and fat mass (kg). NAFLD was diagnosed via ultrasononography and a subset of participants with NAFLD (n=40) underwent a liver biopsy. The lowest tertile had a significantly higher risk for obesity, dyslipidemia, insulin resistance, metabolic syndrome, NAFLD, and nonalcoholic steatohepatitis (NASH). The present study demonstrated an association between low muscle mass, NAFLD, and NASH in overweight/obese youth. Despite the strong scientific merits of the present study, a lack of race/ethnic description could be a major critique as different ethnic background (specifically in the minorities) may be disproportionately impacted by fat distribution and relative muscle mass. Even though there is a clear relationship between sarcopenia and NAFLD in the elderly, this association may not stem from the same origin in the pediatric population. Lastly, but not least, future studies should evaluate NAFLD in obese youth with varying degrees of metabolic disorders (i.e., metabolic syndrome).

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