scholarly journals Clinical significance of quantitative bone SPECT/CT in the evaluation of hand and wrist pain in patients with rheumatic disease

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Chae Hong Lim ◽  
Hyun-Sook Kim ◽  
Kyung-Ann Lee ◽  
JongSun Kim ◽  
Soo Bin Park
Keyword(s):  
Computed Tomography ◽  
Rheumatic Diseases ◽  
Roc Curve ◽  
Photon Emission ◽  
Curve Analysis ◽  
Wrist Pain ◽  
Emission Computed Tomography ◽  
Roc Curve Analysis ◽  
Quantitative Spect ◽  
Wrist Joints

AbstractWe investigated the diagnostic value of the maximum standardized uptake value (SUV) at hand and wrist joints for differentiating rheumatic diseases via bone single-photon emission computed tomography (SPECT)/computed tomography (CT). A total of 84 patients manifesting hand and wrist pain (58 women; age, 49.8 ± 15.4 years) were finally diagnosed with rheumatoid arthritis (RA, n = 42), osteoarthritis (OA, n = 16), fibromyalgia (FM, n = 2), and other rheumatic diseases (n = 24). The SUV of each patient was measured in 32 joints including the distal interphalangeal (DIP), proximal interphalangeal (PIP), metacarpophalangeal (MCP), and wrist joints bilaterally. Differences in pain and SUVs between specific rheumatic diseases were assessed using the chi-squared test or one-way analysis of variance. Using the highest SUV (hSUV) in each patient, the diagnostic performance in differentiating specific diseases was evaluated by receiver operating characteristic (ROC) curve analysis. Pain symptoms were present in 886 (33.0%) sites in a total of 2688 joints. In four joint groups (DIP, PIP, MCP, and wrist), the SUVs of joints with pain were significantly higher than those of pain-free joints (all P < 0.001). Active joint sites with higher SUVs than the median value of each joint group were the most common in RA (55.1%). RA showed the greatest hSUV in the PIP (3.0 ± 2.4), MCP (3.5 ± 3.4), and wrist (3.3 ± 1.9) joint groups. FM was characterized by the lowest hSUV of all joint groups. In ROC curve analysis, the cumulative hSUV of the PIP, MCP, and wrist joint groups showed good performance for evaluating RA (area under the curve (AUC), 0.668; P = 0.005). The summation of the hSUVs at all joint groups had an excellent predictive performance for FM (AUC, 0.878; P < 0.001). Consequently, the arthritic activity of the hand and wrist joints based on SUV differed according to specific rheumatic diseases. Quantitative SPECT/CT may provide objective information related to arthritic activity for differentiating specific rheumatic diseases.

scholarly journals Semi-Quantitative Chest Computed tomography Score in Novel Coronavirus (SARS-Cov-2) Patients: Its Correlation with Oxygen Saturation (SpO2) and Role in Predicting Oxygen Therapy Requirement.

2021 ◽  
Author(s):  
Ramamurthy S. Komatlapalli ◽  
Abhishek Jagdishchander Arora ◽  
Rajani Thakur
Keyword(s):  
Computed Tomography ◽  
Oxygen Saturation ◽  
Negative Correlation ◽  
Roc Curve ◽  
Oxygen Therapy ◽  
Curve Analysis ◽  
Scatter Plot ◽  
Roc Curve Analysis ◽  
Strong Negative Correlation ◽  
Novel Coronavirus

Abstract Context: Quantitative and semi-quantitative indicators of lung involvement in COVID-19 could help to stratify the patients and thus help in triaging and speeding up the entire workflow in hospitals as patients with higher severity scores require early therapeutic intervention and critical care.Objective: To calculate Computed Tomography (CT) severity score for COVID-19 infection based on lobar involvement of the disease and correlate the score with oxygen saturation levels (SpO2) of the patient and further predict oxygen therapy requirement.Settings and Design: Prospective study.Methods and Material: This is a prospective study of 154 proven novel coronavirus (SARS-CoV-2) infected (COVID-19) patients. SpO2 values of all the patients were obtained within 6 hours of scan. All the scans were reviewed and semi-quantitative CT score was calculated based on the extent of lobar involvement Statistical analysis used: Scatter plot correlation and ROC curve analysis were performed. Results: CT score and SpO2 values of patients were plotted in scatter plot chart and Pearson correlation co-efficient (r) was calculated, which was -0.836 suggesting a strong negative correlation. Forty-six patients were given oxygen therapy and they had oxygen saturation value ≤ 94% with CT score ranging from 10-22. ROC curve analysis was performed to determine and reach an optimum cut off value of 11 for oxygen therapy requirement with sensitivity and specificity of 95.83% and 95.58% respectively. Conclusions: CT score in COVID-19 patients has strong negative correlation with oxygen saturation and it definitely helped to predict the requirement of the oxygen therapy in our study.

scholarly journals The Primary Ciliary Dyskinesia Computed Tomography Score in Adults with Bronchiectasis: A Derivation und Validation Study

Respiration ◽  
2021 ◽  
pp. 1-11
Author(s):  
Jessica Rademacher ◽  
Sabine Dettmer ◽  
Jan Fuge ◽  
Jens Vogel-Claussen ◽  
Hoen-oh Shin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Roc Curve ◽  
Primary Ciliary Dyskinesia ◽  
Validation Cohort ◽  
Lower Lobe ◽  
Curve Analysis ◽  
Diagnostic Workup ◽  
Roc Curve Analysis ◽  
Etiological Diagnosis ◽  
Ciliary Dyskinesia

<b><i>Background:</i></b> Primary ciliary dyskinesia (PCD) is a rare genetic disorder which requires a complex diagnostic workup. Thus, an easy and widely available screening method would be helpful to identify patients who need a further diagnostic workup for PCD. <b><i>Objectives:</i></b> The aim of the study was to develop and validate a computed tomography (CT) score for PCD to facilitate etiological diagnosis in adults with bronchiectasis. <b><i>Method:</i></b> Chest CTs from 121 adults with bronchiectasis were scored for bronchiectasis morphology, distribution, and associated findings. Patients with and without the etiological diagnosis of PCD (46 and 75, respectively) were compared. Significantly, different imaging findings (<i>p</i> &#x3c; 0.05) in univariate analysis were considered for multivariate analysis. Distinct findings were used to build the score. Based on this score, receiver operating characteristic (ROC) curve analysis was performed. The score was validated with 2 independent cohorts, another cohort from the same institution with 56 patients (28 with PCD) and an external cohort from another referral center with 172 patients (86 with PCD). <b><i>Results:</i></b> The following parameters predicted PCD in adults with bronchiectasis and were included in the score with weighting according to their regression coefficients: 2 points were given for predominance in the middle/lower lobe, 2 points for tree-in-bud pattern, 2 points for atelectasis or prior resection of a middle/lower lobe, and 3 points for absence of emphysema and fibrosis. Situs inversus was only observed in subjects with PCD (Kartagener syndrome) and, thus, was not used in the primary ciliary dyskinesia computed tomography (PCD-CT) score as group comparisons could not be performed. ROC curve analysis revealed an area under the curve (AUC) of 0.90 (95% CI 0.85–0.96). Youden index was the highest at a threshold of &#x3e;6 with a sensitivity of 83% and a specificity of 83%. In the validation cohorts, ROC curve analysis confirmed the performance of the score with an AUC of 0.83 (95% CI 0.72–0.94) in the first validation cohort and 0.79 (95% CI 0.73–0.86) in the external validation cohort. <b><i>Conclusions:</i></b> The PCD-CT score provides the first validated CT score for PCD and helps physicians in identifying adult bronchiectasis patients who require further diagnostic workup. <b><i>Key message:</i></b> The PCD-CT score provides the first validated CT score to assist physicians in identifying adult bronchiectasis patients who require a further diagnostic workup for PCD. It potentially improves earlier recognition of this rare and underdiagnosed disease.

scholarly journals Quantitative bone single-photon emission computed tomography imaging for uninfected nonunion: comparison of hypertrophic nonunion and non-hypertrophic nonunion

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract Background Recently, a standardized uptake value (SUV) has been used to evaluate bone single-photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters. Methods We evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using the GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. Results The values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23)). Conclusions SUVmax, SUVpeak, and SUVmean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

scholarly journals Quantitative Bone Single Photon Emission Computed Tomography Imaging for Uninfected Nonunion: Comparison of Hypertrophic Nonunion and Non-Hypertrophic Nonunion

2020 ◽  
Author(s):  
Keisuke Oe ◽  
Feibi Zeng ◽  
Tomoaki Fukui ◽  
Munenobu Nogami ◽  
Takamichi Murakami ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Quantitative Spect ◽  
Quantitative Parameters ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Abstract BackgroundRecently, a standardized uptake value (SUV) has been used to evaluate bone single photon emission computed tomography (SPECT). The aim of this study was to investigate quantitative SPECT imaging of uninfected nonunion to compare hypertrophic nonunion and non-hypertrophic nonunion using volume-based parameters.MethodsWe evaluated 23 patients with uninfected nonunion who underwent SPECT acquisition 3 h after an injection of 99mTc-hydroxymethylene diphosphonate or 99mTc-methylene diphosphonate from April 2014 to November 2019. We reconstructed the acquired data and performed voxel-based quantitative analysis using GI-BONE software. Quantitative parameters, maximum SUV (SUVmax), peak SUV (SUVpeak), and mean SUV (SUVmean) in the high and low uptake areas of nonunion were compared between hypertrophic nonunion and non-hypertrophic nonunion. The contralateral limb was used as a control, and the ratios of the quantitative parameters were calculated. ResultsThe values for the quantitative parameters (high uptake area/low uptake area, respectively), SUVmax control ratio (12.13 ± 4.95/6.44 ± 4.71), SUVpeak control ratio (11.65 ± 4.58/6.45 ± 4.64), and SUVmean control ratio (11.94 ± 5.03/6.28 ± 4.95) for hypertrophic nonunion were higher than those for non-hypertrophic nonunion (7.82 ± 4.76/3.41 ± 2.09 (p = 0.065/0.12), 7.56 ± 4.51/3.61 ± 2.23 (p = 0.065/0.22), and 7.59 ± 5.18/3.05 ± 1.91 (p = 0.076/0.23). ConclusionsSUVmax, peak, mean control ratios obtained from bone SPECT images can quantitatively evaluate the biological activity of nonunions and may be an effective evaluation method for treatment decisions, especially the necessity of autologous bone grafting.

scholarly journals Standardized Uptake Value Using Thyroid Quantitative SPECT/CT for the Diagnosis and Evaluation of Graves’ Disease: A Prospective Multicenter Study

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Feng Dong ◽  
Lin Li ◽  
Yanzhu Bian ◽  
Guoquan Li ◽  
Xingmin Han ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Clinical Diagnosis ◽  
Multicenter Study ◽  
Photon Emission ◽  
Standardized Uptake Value ◽  
Control Group ◽  
Emission Computed Tomography ◽  
Graves Disease ◽  
Prospective Multicenter Study ◽  
Quantitative Spect

The clinical applications of the quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) are being expanded to a variety of fields of nuclear medicine. However, clinical application of quantitative SPECT/CT for the evaluation of Graves’ disease (GD) still needs further investigation. Our aim was to investigate the feasibility of standard uptake value (SUV) of the thyroid for the clinical diagnosis and evaluation of GD. In this prospective multicenter study, 116 patients diagnosed with GD (Graves group) and 74 healthy volunteers (control group) were enrolled from 8 different hospitals. All patients underwent technetium pertechnetate (TcO99m4-) SPECT/CT imaging with Q.Metrix quantitative software and 24-hour thyroid radioactive iodine uptake (24h-RAIU) test. The SUVmax and SUVmean in Graves group were significantly higher than those of control group (P<0.01). Cut-off values of SUVmax and SUVmean to predict GD were 231.425 and 116.66 by ROC curves, respectively. The SUVmax and SUVmean in Graves patients were significantly related to serum thyroxine level with correlation coefficient of 0.493 and 0.512 for FT3and 0.449 and 0.464 for FT4, respectively (allP<0.01). Additionally, the SUVmax and SUVmean in GD positively correlated with 24h-RAIU with a coefficient of 0.832 and 0.830, respectively (P<0.01). The volumes determined by Q.Metrix (35.65 ± 20.56ml) of 72 subjects also positively correlated with that from ultrasound (36.67 ± 21.00ml) with a coefficient of 0.927 (P<0.01). SUV measurements derived from thyroid SPECT/CT may be useful for the clinical diagnosis and evaluation of GD.

scholarly journals Performance of computed tomography angiography to determine anterograde and collateral blood flow status in patients with symptomatic middle cerebral artery stenosis

2017 ◽  
Vol 23 (3) ◽  
pp. 267-273 ◽  
Author(s):  
Baixue Jia ◽  
David S Liebeskind ◽  
Ligang Song ◽  
Xiaotong Xu ◽  
Xuan Sun ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Roc Curve ◽  
Computed Tomography Angiography ◽  
Scoring System ◽  
Curve Analysis ◽  
Collateral Blood Flow ◽  
Roc Curve Analysis ◽  
Conventional Angiography

Background The purpose of this study was to determine the performance of computed tomography angiography (CTA) by using a scoring system to predict anterograde and collateral blood flow status in patients with symptomatic middle cerebral artery (MCA) stenosis with use of conventional angiography as standard reference. Methods We retrospectively identified all consecutive patients with unilateral symptomatic MCA stenosis in our center who underwent conventional angiography and CTA within 1 month. The anterograde and collateral blood flow (AnCo) scoring system consisted of anterograde score (AnS) and collateral score (CoS). Evaluation of the CTA images was done independently by two readers, based on the AnCo scoring system. The conventional angiography was assessed by using the Thrombolysis in Cerebral Infarction (TICI) and American Society of Interventional and Therapeutic Neuroradiology (ASITN/SIR) scoring system to determine the status of anterograde and collateral blood flow. Diagnostic performance of AnCo was evaluated by using the area under the receiver operating characteristic (ROC) curve. Results A total of 61 patients were included in the analysis with mean age of 53.4 ± 11.0 years. AnS demonstrated a strong correlation with TICI with statistical significance ( r = 0.786; p < 0.001). CoS had a modest yet statistically significant correlation with ASITN/SIR ( r = 0.574; p < 0.001). The ROC curve analysis for AnS demonstrated an area under the curve (AUC) of 0.894 ( p < 0.001) and the ROC curve analysis for CoS showed an AUC of 0.824 ( p < 0.001). Conclusions CTA was a potential method to evaluate anterograde and collateral blood flow status in patients with symptomatic unilateral MCA stenosis.

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