scholarly journals Author Correction: Mapping the genetic basis of diabetes mellitus in the Australian Burmese cat (Felis catus)

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Georgina Samaha ◽  
Claire M. Wade ◽  
Julia Beatty ◽  
Leslie A. Lyons ◽  
Linda M. Fleeman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Basis ◽  
Felis Catus

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

scholarly journals The quality of life in the relatives of Wolfram’s syndrome patients

2014 ◽  
Vol 5 (1) ◽  
pp. 89-97
Author(s):  
Gema Esteban ◽  
Mónica Ruano ◽  
Isabel Motero
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Genetic Basis ◽  
Clinical Symptoms ◽  
Daily Life ◽  
Wolfram Syndrome ◽  
Clinical Aspects ◽  
The Family ◽  
Low Prevalence

Wolfram Syndrome (WS) is a rare disease (RD) with an estimated prevalence of 1/770,000 inhabitants. It is considered a multisystemic, chronic and progressive disease.WS diagnosis implies devastating consequences at physical, educational and emotional levels. WS is also known by the acronym DIDMOAD, derived from the first letters of the main clinical symptoms: Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness. Rare diseases are characterized by their low prevalence and the lack of knowledge on the pathophysiology and treatment of them. Interestingly, around 80% of RD have a genetic basis, and this fact causes doubts and uncertainties in the couples, about the idea of having another child. The existence of a RD in a family, alters significantly the relationships and the quality of life within the family. The present work remarks the huge value of psychosocial aspects in order to pay an adequate attention to these patients, not only taking care of the clinical aspects. The main purpose of this study has been to ascertain the quality of life of Wolfram’s syndrome affected patients, and its impact in the daily life.

scholarly journals Peripheral Pathways in the Food-Intake Control towards the Adipose-Intestinal Missing Link

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Hugo Mendieta Zerón ◽  
Ma. Victoria Domínguez García ◽  
María del Socorro Camarillo Romero ◽  
Miriam V. Flores-Merino
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Basis ◽  
Physiological State ◽  
Hormone Secretion ◽  
Gut Hormones ◽  
Diabetic Patients ◽  
Early Presentation ◽  
Gut Hormone ◽  
Unknown Factor

In the physiological state a multitude of gut hormones are released into the circulation at the same time depending on the quality and quantity of the diet. These hormones interact with receptors at various points in the “gut-brain axis” to affect short-term and intermediate-term feelings of hunger and satiety. The combined effects of macronutrients on the predominant gut hormone secretion are still poorly understood. Besides, adipokines form an important part of an “adipoinsular axis” dysregulation which may contribute toβ-cell failure and hence to type 2 diabetes mellitus (T2DM). Even more, gestational diabetes mellitus (GDM) and T2DM seem to share a genetic basis. In susceptible individuals, chronic exaggerated stimulation of the proximal gut with fat and carbohydrates may induce overproduction of an unknown factor that causes impairment of incretin production and/or action, leading to insufficient or untimely production of insulin, so that glucose intolerance develops. The bypass of the duodenum and jejunum might avoid a putative hormone overproduction in the proximal foregut in diabetic patients that might counteract the action of insulin, while the early presentation of undigested or incompletely digested food to the ileum may anticipate the production of hormones such as GLP1, further improving insulin action.

GENETIC BASIS OF ENDOCRINE DISEASE 1 Molecular Genetics of Insulin Resistant Diabetes Mellitus

1991 ◽  
Vol 73 (6) ◽  
pp. 1158-1163 ◽  
Author(s):  
SIMEON I. TAYLOR ◽  
ALESSANDRO CAMA ◽  
DOMENICO ACCILI ◽  
FABRIZIO BARBETTI ◽  
EIICHI IMANO ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Molecular Genetics ◽  
Genetic Basis ◽  
Endocrine Disease ◽  
Insulin Resistant

Genetic Basis of Type 2 Diabetes Mellitus

2004 ◽  
Vol 3 (4) ◽  
pp. 257-267 ◽  
Author(s):  
Johanna K Wolford ◽  
Barbora Vozarova de Courten
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Basis

Genetics of type 2 diabetes mellitus

2011 ◽  
pp. 1734-1740 ◽  
Author(s):  
Niels Grarup ◽  
Torben Hansen ◽  
Oluf Pedersen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Basis ◽  
Genetic Factors ◽  
Molecular Genetic ◽  
Common Type ◽  
Molecular Pathogenesis ◽  
Molecular Genetic Basis

For years, it has been well known that genetic factors are crucially important for the development of type 2 diabetes. Despite major efforts in seeking to understand the molecular genetic basis, until a few years ago, only a handful of genes responsible for relatively rare monogenic and syndromic subsets of diabetes were detected, and progress in finding genetic predispositions to common type 2 diabetes was lacking. Even though the unravelling of the molecular pathogenesis of type 2 diabetes is still in its infancy, the last few years have, nevertheless, brought some interesting developments. Box 13.3.1.1 provides a glossary of terms used currently in genetics.

scholarly journals The genetic basis of high-carbohydrate and high-monosodium glutamate diet related to the increase of likelihood of type 2 diabetes mellitus: a review

Endocrine ◽  
2020 ◽  
Vol 69 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Joshua Nathanael ◽  
Hans Cristian Adhinatya Harsono ◽  
Aubrey Druce Wibawa ◽  
Putu Suardana ◽  
Yoanes Maria Vianney ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Basis ◽  
Monosodium Glutamate ◽  
High Carbohydrate
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