Relationship between post-traumatic amnesia and white matter integrity in traumatic brain injury using tract-based spatial statistics

AbstractThis study used tract-based spatial statistics to examine the relationship between post-traumatic amnesia (PTA) and white matter integrity in patients with a traumatic brain injury (TBI). Forty-seven patients with TBI in the chronic stage and 47 age- and sex-matched normal control subjects were recruited to the study. Correlation coefficients were calculated to observe the relationships among the PTA duration, white matter fractional anisotropy (FA) values, and mini-mental state examination (MMSE) results in the patient group. Both before and after Benjamini–Hochberg (BH) corrections, FA values of 46 of the 48 regions of interests of the patient group were lower than those of the control group. The FA values of column and body of fornix, left crus of fornix, left uncinate fasciculus, right hippocampus part of cingulum, left medial lemniscus, right superior cerebellar peduncle, left superior cerebellar peduncle, and left posterior thalamic radiation (after BH correction: the uncinate fasciculus and right hippocampus part of cingulum) in the patient group were negatively correlated with PTA duration. PTA duration was related to the injury severity of eight neural structures, each of which is involved in the cognitive functioning of patients with TBI. Therefore, PTA duration can indicate injury severity of the above neural structures in TBI patients.

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Are Anesthesia and Surgery during Infancy Associated with Decreased White Matter Integrity and Volume during Childhood?

Anesthesiology ◽

10.1097/aln.0000000000001808 ◽

2017 ◽

Vol 127 (5) ◽

pp. 788-799 ◽

Cited By ~ 10

Author(s):

Robert I. Block ◽

Vincent A. Magnotta ◽

Emine O. Bayman ◽

James Y. Choi ◽

Joss J. Thomas ◽

...

Keyword(s):

White Matter ◽

Mean Diffusivity ◽

White Matter Integrity ◽

Cerebral Peduncle ◽

Intracranial Volume ◽

Healthy Children ◽

Superior Cerebellar Peduncle ◽

Control Subjects ◽

Brain White Matter ◽

Cerebellar Peduncle

AbstractBackgroundAnesthetics have neurotoxic effects in neonatal animals. Relevant human evidence is limited. We sought such evidence in a structural neuroimaging study.MethodsTwo groups of children underwent structural magnetic resonance imaging: patients who, during infancy, had one of four operations commonly performed in otherwise healthy children and comparable, nonexposed control subjects. Total and regional brain tissue composition and volume, as well as regional indicators of white matter integrity (fractional anisotropy and mean diffusivity), were analyzed.ResultsAnalyses included 17 patients, without potential confounding central nervous system problems or risk factors, who had general anesthesia and surgery during infancy and 17 control subjects (age ranges, 12.3 to 15.2 yr and 12.6 to 15.1 yr, respectively). Whole brain white matter volume, as a percentage of total intracranial volume, was lower for the exposed than the nonexposed group, 37.3 ± 0.4% and 38.9 ± 0.4% (least squares mean ± SE), respectively, a difference of 1.5 percentage points (95% CI, 0.3 to 2.8; P = 0.016). Corresponding decreases were statistically significant for parietal and occipital lobes, infratentorium, and brainstem separately. White matter integrity was lower for the exposed than the nonexposed group in superior cerebellar peduncle, cerebral peduncle, external capsule, cingulum (cingulate gyrus), and fornix (cres) and/or stria terminalis. The groups did not differ in total intracranial, gray matter, and cerebrospinal fluid volumes.ConclusionsChildren who had anesthesia and surgery during infancy showed broadly distributed, decreased white matter integrity and volume. Although the findings may be related to anesthesia and surgery during infancy, other explanations are possible.

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Altered White Matter Integrity after Mild to Moderate Traumatic Brain Injury

Journal of Clinical Medicine ◽

10.3390/jcm8091318 ◽

2019 ◽

Vol 8 (9) ◽

pp. 1318 ◽

Cited By ~ 3

Author(s):

Kim ◽

Seo ◽

Lee ◽

Choi ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

White Matter ◽

Cognitive Dysfunction ◽

Diffusion Tensor ◽

Balance Control ◽

White Matter Integrity ◽

Moderate Traumatic Brain Injury ◽

Impaired Balance ◽

Cerebellar Peduncle

(1) Background: White matter changes among individuals with mild-to-moderate traumatic brain injury (TBI) may be sensitive imaging markers reflecting functional impairment, particularly in the context of post-concussion syndrome. The objective of this study was to examine the altered white matter integrity in mild-to-moderate TBI patients compared with age-matched normal controls. (2) Methods: Diffusion tensor imaging data from 15 individuals with TBI and 15 control subjects were retrospectively obtained. We investigated and compared white matter integrity in both groups, with regard to fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD) and examined the relationship with cognitive dysfunction and impaired balance in patients. (3) Results: In comparison with controls, the TBI patients had significantly decreased FA as well as increased RD, in the right corticospinal tract. Decreased RD was observed in the left cerebellar area near the middle cerebellar peduncle. Decreased AD was observed in the left inferior cerebellar peduncle, showing positive correlation with poor balance control. We observed decreased FA and increased AD in the left superior longitudinal fasciculus showing positive and negative correlation, respectively, with cognitive function in the TBI group. (4) Conclusions: Altered white matter integrity in mild-to-moderate TBI cases may be indicative of cognitive dysfunction and impaired balance.

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Decreases in White Matter Integrity of Ventro-Limbic Pathway Linked to Post-Traumatic Stress Disorder in Mild Traumatic Brain Injury

Journal of Neurotrauma ◽

10.1089/neu.2017.5541 ◽

2019 ◽

Vol 36 (7) ◽

pp. 1093-1098 ◽

Cited By ~ 5

Author(s):

Priya Santhanam ◽

Theresa Teslovich ◽

Steffanie H. Wilson ◽

Ping-Hong Yeh ◽

Terrence R. Oakes ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

White Matter ◽

Mild Traumatic Brain Injury ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Stress Disorder ◽

White Matter Integrity ◽

Post Traumatic Stress ◽

Post Traumatic

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Post-traumatic amnesia and the nature of post-traumatic stress disorder after mild traumatic brain injury

Journal of the International Neuropsychological Society ◽

10.1017/s1355617709990671 ◽

2009 ◽

Vol 15 (6) ◽

pp. 862-867 ◽

Cited By ~ 65

Author(s):

RICHARD A. BRYANT ◽

MARK CREAMER ◽

MEAGHAN O’DONNELL ◽

DERRICK SILOVE ◽

C. RICHARD CLARK ◽

...

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Injury Severity ◽

Stress Disorder ◽

Post Traumatic Stress ◽

Traumatic Amnesia ◽

Post Traumatic

AbstractThe prevalence and nature of post-traumatic stress disorder (PTSD) following mild traumatic brain injury (MTBI) is controversial because of the apparent paradox of suffering PTSD with impaired memory for the traumatic event. In this study, 1167 survivors of traumatic injury (MTBI: 459, No TBI: 708) were assessed for PTSD symptoms and post-traumatic amnesia during hospitalization, and were subsequently assessed for PTSD 3 months later (N = 920). At the follow-up assessment, 90 (9.4%) patients met criteria for PTSD (MTBI: 50, 11.8%; No-TBI: 40, 7.5%); MTBI patients were more likely to develop PTSD than no-TBI patients, after controlling for injury severity (adjusted odds ratio: 1.86; 95% confidence interval, 1.78–2.94). Longer post-traumatic amnesia was associated with less severe intrusive memories at the acute assessment. These findings indicate that PTSD may be more likely following MTBI, however, longer post-traumatic amnesia appears to be protective against selected re-experiencing symptoms. (JINS, 2009, 15, 862–867.)

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