scholarly journals Identification of clinical and radiographic predictors of central nervous system injury in genetic skeletal disorders

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Antônio L Cunha ◽  
Ana P S Champs ◽  
Carla M. Mello ◽  
Mônica M. M. Navarro ◽  
Frederico J. C. Godinho ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Spinal Cord Injury ◽  
Nervous System ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Cns Injury ◽  
Cord Injury ◽  
Skeletal Disorders

AbstractSome studies report neurological lesions in patients with genetic skeletal disorders (GSDs). However, none of them describe the frequency of neurological lesions in a large sample of patients or investigate the associations between clinical and/or radiological central nervous system (CNS) injury and clinical, anthropometric and imaging parameters. The project was approved by the institution’s ethics committee (CAAE 49433215.5.0000.0022). In this cross-sectional observational analysis study, 272 patients aged four or more years with clinically and radiologically confirmed GSDs were prospectively included. Genetic testing confirmed the diagnosis in the FGFR3 chondrodysplasias group. All patients underwent blinded and independent clinical, anthropometric and neuroaxis imaging evaluations. Information on the presence of headache, neuropsychomotor development (NPMD), low back pain, joint deformity, ligament laxity and lower limb discrepancy was collected. Imaging abnormalities of the axial skeleton and CNS were investigated by whole spine digital radiography, craniocervical junction CT and brain and spine MRI. The diagnostic criteria for CNS injury were abnormal clinical and/or radiographic examination of the CNS. Brain injury included malacia, encephalopathies and malformation. Spinal cord injury included malacia, hydrosyringomyelia and spinal cord injury without radiographic abnormalities. CNS injury was diagnosed in more than 25% of GSD patients. Spinal cord injury was found in 21.7% of patients, and brain injury was found in 5.9%. The presence of low back pain, os odontoideum and abnormal NPMD remained independently associated with CNS injury in the multivariable analysis. Early identification of these abnormalities may have some role in preventing compressive CNS injury, which is a priority in GSD patients.

A systematic review of the prevalence of musculoskeletal pain, back and low back pain in people with spinal cord injury

2013 ◽  
Vol 36 (9) ◽  
pp. 705-715 ◽  
Author(s):  
Christina Michailidou ◽  
Louise Marston ◽  
Lorraine H. De Souza ◽  
Ian Sutherland
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Low Back Pain ◽  
Back Pain ◽  
Musculoskeletal Pain ◽  
Low Back ◽  
Cord Injury

Adaptation of Torso Movement Strategies in Persons With Spinal Cord Injury or Low Back Pain

Spine ◽  
2010 ◽  
Vol 35 (19) ◽  
pp. 1753-1759 ◽  
Author(s):  
K. Han Kim ◽  
Su Bang Choe ◽  
Andrew J. Haig ◽  
Bernard J. Martin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Low Back Pain ◽  
Back Pain ◽  
Low Back ◽  
Movement Strategies ◽  
Cord Injury

scholarly journals Prevalence of musculoskeletal problems in caregivers handling non-ambulatory spinal cord injury patients

2021 ◽  
Vol 7 (9) ◽  
pp. 454
Author(s):  
Pranjali Kulkarni ◽  
Manish Ray ◽  
Ashok Shyam ◽  
Parag Sancheti
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Low Back Pain ◽  
Back Pain ◽  
Cross Sectional Study ◽  
Low Back ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Cord Injury ◽  
Musculoskeletal Problems

<p class="abstract"><strong>Background:</strong> Spinal cord injury (SCI) is a distressing disorder that can cause of loss of physical, psychological and social functioning, that can cause high level of disability in patients. Due to disability, they are dependent on caregivers for their daily activities. Caregivers of SCI can be family or professional caregivers. Due to lack of training and awkward posture, caring for SCI patients may be burdensome which results in musculoskeletal problems in caregivers so it is important to find out the prevalence of musculoskeletal problems. The objectives were to find out the prevalence of musculoskeletal problems in caregivers handling non-ambulatory SCI patients and most common site of injury.</p><p class="abstract"><strong>Methods:</strong> A cross sectional study was carried out on 80 caregivers including both professional and family caregivers. Self-structured validated questionnaire used to interview the caregivers based on convenient sampling. The data was analysed by descriptive statistics.</p><p class="abstract"><strong>Results:</strong> The prevalence of musculoskeletal problems is 95% in caregivers including both family and professional caregivers. Low back pain was the commonest site of symptoms (53%) followed by 15% neck, 12% upper back pain, right shoulder (10%), right wrist (5%) and no pain (5%).</p><p class="abstract"><strong>Conclusions:</strong> The prevalence of musculoskeletal problems in caregivers handling non ambulatory SCI is high. Most affected area is low back pain and neck pain. The findings of the study indicated that proper training and exercise are required, on means of preventing musculoskeletal problems.</p><p> </p>

scholarly journals Role of NETosis in Central Nervous System Injury

2022 ◽  
Vol 2022 ◽  
pp. 1-15
Author(s):  
Yituo Chen ◽  
Haojie Zhang ◽  
Xinli Hu ◽  
Wanta Cai ◽  
Wenfei Ni ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Central Nervous System ◽  
Spinal Cord Injury ◽  
Cell Death ◽  
Nervous System ◽  
Brain Injury ◽  
Cns Injury ◽  
Cell Death Pathways ◽  
Cord Injury

Central nervous system (CNS) injury is divided into brain injury and spinal cord injury and remains the most common cause of morbidity and mortality worldwide. Previous reviews have defined numerous inflammatory cells involved in this process. In the human body, neutrophils comprise the largest numbers of myeloid leukocytes. Activated neutrophils release extracellular web-like DNA amended with antimicrobial proteins called neutrophil extracellular traps (NETs). The formation of NETs was demonstrated as a new method of cell death called NETosis. As the first line of defence against injury, neutrophils mediate a variety of adverse reactions in the early stage, and we consider that NETs may be the prominent mediators of CNS injury. Therefore, exploring the specific role of NETs in CNS injury may help us shed some light on early changes in the disease. Simultaneously, we discovered that there is a link between NETosis and other cell death pathways by browsing other research, which is helpful for us to establish crossroads between known cell death pathways. Currently, there is a large amount of research concerning NETosis in various diseases, but the role of NETosis in CNS injury remains unknown. Therefore, this review will introduce the role of NETosis in CNS injury, including traumatic brain injury, cerebral ischaemia, CNS infection, Alzheimer’s disease, and spinal cord injury, by describing the mechanism of NETosis, the evidence of NETosis in CNS injury, and the link between NETosis and other cell death pathways. Furthermore, we also discuss some agents that inhibit NETosis as therapies to alleviate the severity of CNS injury. NETosis may be a potential target for the treatment of CNS injury, so exploring NETosis provides a feasible therapeutic option for CNS injury in the future.

Shoulder muscular activity in individuals with low back pain and spinal cord injury during seated manual load transfer tasks

Ergonomics ◽  
2018 ◽  
Vol 61 (8) ◽  
pp. 1094-1101
Author(s):  
Clark R. Dickerson ◽  
Talia Alenabi ◽  
Bernard J. Martin ◽  
Don B. Chaffin
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Low Back Pain ◽  
Back Pain ◽  
Load Transfer ◽  
Muscular Activity ◽  
Low Back ◽  
Cord Injury ◽  
Transfer Tasks

scholarly journals Poststroke Pain – but Multiple Pain Mechanisms

2010 ◽  
Vol 15 (1) ◽  
pp. 24-26 ◽  
Author(s):  
Vinjamuri Chari ◽  
Eldon Tunks
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Low Back Pain ◽  
Back Pain ◽  
Heterotopic Ossification ◽  
Hemorrhagic Stroke ◽  
Central Pain ◽  
Low Back ◽  
Pain Mechanisms ◽  
Cord Injury

A 42-year-old man presented with acute left hemiplegia due to a right frontotemporal hemorrhagic stroke and left-sided pain. While the initial presentation suggested central poststroke pain, subsequent investigations also implicated heterotopic ossification of the left hip and amplification of previous low back pain by the new central pain. While heterotopic ossification has been commonly associated with brain injury, spinal cord injury or osseous injury, it is only rarely associated with stroke. Poststroke pain may be multifactorial, and discovering the pain mechanisms has important implications for treatment.

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