scholarly journals Publisher Correction: A hidden Markov model for lymphatic tumor progression in the head and neck

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Roman Ludwig ◽  
Bertrand Pouymayou ◽  
Panagiotis Balermpas ◽  
Jan Unkelbach
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Roman Ludwig ◽  
Bertrand Pouymayou ◽  
Panagiotis Balermpas ◽  
Jan Unkelbach

AbstractCurrently, elective clinical target volume (CTV-N) definition for head and neck squamous cell carcinoma (HNSCC) is mostly based on the prevalence of nodal involvement for a given tumor location. In this work, we propose a probabilistic model for lymphatic metastatic spread that can quantify the risk of microscopic involvement in lymph node levels (LNL) given the location of macroscopic metastases and T-category. This may allow for further personalized CTV-N definition based on an individual patient’s state of disease. We model the patient's state of metastatic lymphatic progression as a collection of hidden binary random variables that indicate the involvement of LNLs. In addition, each LNL is associated with observed binary random variables that indicate whether macroscopic metastases are detected. A hidden Markov model (HMM) is used to compute the probabilities of transitions between states over time. The underlying graph of the HMM represents the anatomy of the lymphatic drainage system. Learning of the transition probabilities is done via Markov chain Monte Carlo sampling and is based on a dataset of HNSCC patients in whom involvement of individual LNLs was reported. The model is demonstrated for ipsilateral metastatic spread in oropharyngeal HNSCC patients. We demonstrate the model's capability to quantify the risk of microscopic involvement in levels III and IV, depending on whether macroscopic metastases are observed in the upstream levels II and III, and depending on T-category. In conclusion, the statistical model of lymphatic progression may inform future, more personalized, guidelines on which LNL to include in the elective CTV. However, larger multi-institutional datasets for model parameter learning are required for that.


2012 ◽  
Vol 132 (10) ◽  
pp. 1589-1594 ◽  
Author(s):  
Hayato Waki ◽  
Yutaka Suzuki ◽  
Osamu Sakata ◽  
Mizuya Fukasawa ◽  
Hatsuhiro Kato

MIS Quarterly ◽  
2018 ◽  
Vol 42 (1) ◽  
pp. 83-100 ◽  
Author(s):  
Wei Chen ◽  
◽  
Xiahua Wei ◽  
Kevin Xiaoguo Zhu ◽  
◽  
...  

2016 ◽  
Vol 7 (2) ◽  
pp. 76-82
Author(s):  
Hugeng Hugeng ◽  
Edbert Hansel

We have built an application of speech recognition for Indonesian geography dictionary based on Android operating system, named GAIA. This application uses a smartphone as a device to receive input in the form of a spoken word from a user. The approach used in recognition is Hidden Markov Model which is contained in the Pocketsphinx library. The phonemes used are Indonesian phonemes’ rule. The advantage of this application is that it can be used without internet access. In the application testing, word detection is done with four conditions to determine the level of accuracy. The four conditions are near silent, near noisy, far silent, and far noisy. From the testing and analysis conducted, it can be concluded that GAIA application can be built as a speech recognition application on Android for Indonesian geography dictionary; with the results in the near silent condition accuracy of word recognition reaches an average of 52.87%, in the near noisy reaches an average of 14.5%, in the far silent condition reaches an average of 23.2%, and in the far noisy condition reaches an average of 2.8%. Index Terms—speech recognition, Indonesian geography dictionary, Hidden Markov Model, Pocketsphinx, Android.


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