scholarly journals Rapid changes in brain estrogen concentration during male sexual behavior are site and stimulus specific

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie-Pierre de Bournonville ◽  
Catherine de Bournonville ◽  
Laura M. Vandries ◽  
Gwenaël Nys ◽  
Marianne Fillet ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
In Vivo Microdialysis ◽  
Aromatase Activity ◽  
Sexual Interaction ◽  
Bed Nucleus ◽  
Male Sexual Behavior ◽  
Sexual Stimuli ◽  
Vertebrate Brain ◽  
Rapid Changes

AbstractClassically, estrogens regulate male sexual behavior through effects initiated in the nucleus. However, neuroestrogens, i.e., estrogens locally produced in the brain, can act within minutes via membrane-initiated events. In male quail, rapid changes in brain aromatase activity occur after exposure to sexual stimuli. We report here that local extracellular estrogen concentrations measured by in vivo microdialysis increase during sexual interactions in a brain site- and stimulus-specific manner. Indeed, estrogen concentrations rose within 10 min of the initiation of sexual interaction with a female in the medial preoptic nucleus only, while visual access to a female led to an increase in estrogen concentrations only in the bed nucleus of the stria terminalis. These are the fastest fluctuations in local estrogen concentrations ever observed in the vertebrate brain. Their site and stimulus specificity strongly confirm the neuromodulatory function of neuroestrogens on behavior.

Dual modulation of male sexual behavior in rats by central prolactin: relationship with in vivo striatal dopaminergic activity

1999 ◽  
Vol 24 (7) ◽  
pp. 681-693 ◽  
Author(s):  
Pablo E Cruz-Casallas ◽  
Antonia G Nasello ◽  
Erica E.T.S Hucke ◽  
Luciano F Felicio
Keyword(s):  
Sexual Behavior ◽  
Dopaminergic Activity ◽  
Male Sexual Behavior

scholarly journals Solitary Nitric Oxide Signaling Mediates Mild Stress-Induced Anxiety and Norepinephrine Release in the Bed Nucleus of the Stria Terminalis during Protracted Ethanol Withdrawal

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Zhenglin Zhao ◽  
Sang Chan Kim ◽  
Yu Jiao ◽  
Yefu Wang ◽  
Bong Hyo Lee ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Elevated Plus Maze ◽  
In Vivo Microdialysis ◽  
Ethanol Withdrawal ◽  
Mild Stress ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Nitric Oxide Signaling ◽  
Plus Maze

Ethanol withdrawal (EtOHW) alters the pattern of neurohormonal and behavioral response toward internal and external stimuli, which mediates relapse to alcohol use even after a long period of abstinence. Increased noradrenergic signaling from the nucleus tractus solitarius (NTS) to the bed nucleus of the stria terminalis (BNST) during EtOHW underlies withdrawal-induced anxiety, while nitric oxide synthase (NOS) inhibitors injected into the periaqueductal area attenuate EtOHW-induced anxiety. Therefore, this study investigated the involvement of NOS within the NTS in anxiety and increased norepinephrine (NE) release in the BNST during protracted EtOHW in rats exposed to a mild stress. Rats were intraperitoneally administered 3 g/kg/day EtOH for 21 days followed by 28 days of withdrawal, and on the 28th day of withdrawal, the rats were subjected to restraint stress for 7 minutes. The elevated plus maze test was employed to evaluate anxiety-like behavior in rats, and in vivo microdialysis was used to measure the extracellular NE level in the BNST. In elevated plus maze tests, EtOHW rats but not EtOH-naive rats exhibited anxiety-like behavior when challenged with 7-minute mild restraint stress, which was, respectively, mitigated by prior intra-NTS infusion of the nitric oxide scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (carboxy-PTIO), nonselective NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), or selective neuronal NOS (nNOS) inhibitor 7-nitroindazole (7-NI). Each of these agents also decreased the plasma corticosterone levels in EtOHW rats. In in vivo microdialysis, prior intra-NTS infusion of carboxy-PTIO, L-NAME, or 7-NI attenuated the mild stress-induced NE release in the BNST of EtOHW rats. Additionally, EtOHW rats showed increased solitary nNOS gene and protein expression. Moreover, the anxiolytic effect of intra-NTS administration of 7-NI was abolished by subsequent intra-NTS administration of sodium nitroprusside. These results suggest that elevation of solitary nitric oxide signaling derived from nNOS mediates stress-precipitated anxiety and norepinephrine release in the BNST during protracted EtOHW.

scholarly journals Rapid Decreases in Preoptic Aromatase Activity and Brain Monoamine Concentrations after Engaging in Male Sexual Behavior

Endocrinology ◽  
2005 ◽  
Vol 146 (9) ◽  
pp. 3809-3820 ◽  
Author(s):  
C. A. Cornil ◽  
C. Dalla ◽  
Z. Papadopoulou-Daifoti ◽  
M. Baillien ◽  
C. Dejace ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Aromatase Activity ◽  
Male Sexual Behavior ◽  
Brain Monoamine

Effects of a novel partner and sexual satiety on the expression of male sexual behavior and brain aromatase activity in quail

2019 ◽  
Vol 359 ◽  
pp. 502-515
Author(s):  
Catherine de Bournonville ◽  
Mélanie Schmit ◽  
Maxim Telle ◽  
Lucas Court ◽  
Gregory F. Ball ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Aromatase Activity ◽  
Male Sexual Behavior ◽  
Brain Aromatase

Sexual Behavior in Males From a Neuroendocrine Perspective

2018 ◽  
Author(s):  
Jacques Balthazart ◽  
Gregory F. Ball
Keyword(s):  
Sexual Behavior ◽  
Critical Role ◽  
Time Frame ◽  
Behavioral Activity ◽  
Inactive Compound ◽  
Male Sexual Behavior ◽  
Brain Aromatase ◽  
Rapid Changes ◽  
Androgenic Steroids ◽  
Time Frames

It is well established that testosterone from testicular origin plays a critical role in the activation of male sexual behavior in most, if not all, vertebrate species. These effects take place to a large extent in the preoptic area although other brain sites are obviously also implicated. In its target areas, testosterone is actively metabolized either into estrogenic and androgenic steroids that have specific behavioral effects or into inactive metabolites. These transformations either amplify the behavioral activity of testosterone or, alternatively, metabolism to an inactive compound dissipates any biological effect. Androgens and estrogens then bind to nuclear receptors that modulate the transcription of specific genes. This process is controlled by a variety of co-activators and co-repressors that, respectively, enhance or inhibit these transcriptional processes. In addition, recent work has shown that the production of estrogens by brain aromatase can be modulated within minutes by changes in neural activity and that these rapid changes in neuroestrogen production impact sexual behavior, in particular sexual motivation within the same time frame. Estrogens thus affect specific aspects of male sexual behavior in two different time frames via two types of mechanisms that are completely different. Multiple questions remain open concerning the cellular brain mechanisms that mediate testosterone action on male sexual behavior.

Sign in / Sign up

Export Citation Format

Share Document