scholarly journals High-dose ascorbic acid administration improves functional recovery in rats with spinal cord contusion injury

Spinal Cord ◽  
2014 ◽  
Vol 52 (11) ◽  
pp. 803-808 ◽  
Author(s):  
M Yan ◽  
M Yang ◽  
W Shao ◽  
X-g Mao ◽  
B Yuan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ascorbic Acid ◽  
Functional Recovery ◽  
High Dose ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Acid Administration

scholarly journals Automated Gait Analysis to Assess Functional Recovery in Rodents with Peripheral Nerve or Spinal Cord Contusion Injury

10.3791/61852 ◽  
2020 ◽  
Author(s):  
Johannes Heinzel ◽  
Nicole Swiadek ◽  
Mohamed Ashmwe ◽  
Alexander Rührnößl ◽  
Viola Oberhauser ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Peripheral Nerve ◽  
Gait Analysis ◽  
Functional Recovery ◽  
Contusion Injury ◽  
Spinal Cord Contusion

scholarly journals EGb761 improves histological and functional recovery in rats with acute spinal cord contusion injury

Spinal Cord ◽  
2015 ◽  
Vol 54 (4) ◽  
pp. 259-265 ◽  
Author(s):  
M Yan ◽  
Y-w Liu ◽  
W Shao ◽  
X-g Mao ◽  
M Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Contusion Injury ◽  
Spinal Cord Contusion

Functional Recovery After Central Infusion of α-Melanocyte-Stimulating Hormone in Rats With Spinal Cord Contusion Injury

1999 ◽  
Vol 16 (4) ◽  
pp. 323-331 ◽  
Author(s):  
ALEX J. LANKHORST ◽  
SIMONE E.J. DUIS ◽  
MARIËL P. ter LAAK ◽  
ELBERT A.J. JOOSTEN ◽  
FRANK P.T. HAMERS ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Melanocyte Stimulating Hormone ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Stimulating Hormone

scholarly journals Grafted human induced pluripotent stem cells improve the outcome of spinal cord injury: modulation of the lesion microenvironment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tamás Bellák ◽  
Zoltán Fekécs ◽  
Dénes Török ◽  
Zsuzsanna Táncos ◽  
Csilla Nemes ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Pluripotent Stem Cells ◽  
Functional Improvement ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Induced Pluripotent

AbstractSpinal cord injury results in irreversible tissue damage followed by a very limited recovery of function. In this study we investigated whether transplantation of undifferentiated human induced pluripotent stem cells (hiPSCs) into the injured rat spinal cord is able to induce morphological and functional improvement. hiPSCs were grafted intraspinally or intravenously one week after a thoracic (T11) spinal cord contusion injury performed in Fischer 344 rats. Grafted animals showed significantly better functional recovery than the control rats which received only contusion injury. Morphologically, the contusion cavity was significantly smaller, and the amount of spared tissue was significantly greater in grafted animals than in controls. Retrograde tracing studies showed a statistically significant increase in the number of FB-labeled neurons in different segments of the spinal cord, the brainstem and the sensorimotor cortex. The extent of functional improvement was inversely related to the amount of chondroitin-sulphate around the cavity and the astrocytic and microglial reactions in the injured segment. The grafts produced GDNF, IL-10 and MIP1-alpha for at least one week. These data suggest that grafted undifferentiated hiPSCs are able to induce morphological and functional recovery after spinal cord contusion injury.

scholarly journals Fenretinide Promotes Functional Recovery and Tissue Protection after Spinal Cord Contusion Injury in Mice

2010 ◽  
Vol 30 (9) ◽  
pp. 3220-3226 ◽  
Author(s):  
R. Lopez-Vales ◽  
A. Redensek ◽  
T. A. A. Skinner ◽  
K. I. Rathore ◽  
N. Ghasemlou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Tissue Protection ◽  
Contusion Injury ◽  
Spinal Cord Contusion

Functional recovery after complete contusion injury to the spinal cord and transplantation of human neuroteratocarcinoma neurons in rats

2002 ◽  
Vol 97 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Samuel Saporta ◽  
A. Shahram Makoui ◽  
Alison E. Willing ◽  
Marcel Daadi ◽  
David W. Cahill ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Functional Recovery ◽  
Control Group ◽  
Modest Improvement ◽  
Teratocarcinoma Cell ◽  
Content Type ◽  
Cord Injury ◽  
Contusion Injury ◽  
Spinal Cord Contusion ◽  
Fine Print

Object. Human neuroteratocarcinoma (hNT)—derived neurons are differentiated postmitotic neurons derived from a human teratocarcinoma cell line following treatment with retinoic acid. In preclinical transplantation studies investigators have demonstrated both their safety as a source of neurons for transplantation and efficacy in treating stroke-related behavioral deficits. The objective of this study was to examine whether hNT neurons transplanted in an area of complete spinal cord contusion would improve electrophysiological measures of spinal cord function. Methods. Complete spinal cord contusion injury, defined as the complete loss of motor evoked potentials (MEPs), was produced in 30 rats at T-8. Ten rats with contused spinal cords underwent transplantation with hNT neurons within the site of contusion immediately after injury (immediate transplant group). Ten rats underwent hNT neuron transplantation following a 2-week evaluation for loss of MEPs (delayed transplant group). Ten other rats with contusion injury served as a spinal cord injury control group, and 10 rats underwent only a T-8 laminectomy and served as noninjured controls. All rats survived 8 weeks after transplantation. In the delayed transplant group significant functional recovery was observed, as demonstrated by return of MEPs and a modest improvement of motor function. Immunohistochemical analysis showed the survival, integration, and long fiber outgrowth of the grafted hNT neurons. Conclusions. These findings suggest that the transplantation of the hNT neurons may be an effective means of reestablishing electrical connectivity of the injured spinal cord.

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