scholarly journals Lack of efficacy of Doxil® in TNF-α-based isolated limb perfusion in sarcoma-bearing rats

2004 ◽  
Vol 90 (9) ◽  
pp. 1830-1832 ◽  
Author(s):  
T L M ten Hagen ◽  
S Hoving ◽  
G Ambagtsheer ◽  
S T van Tiel ◽  
A M M Eggermont
Keyword(s):  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Tnf Α

scholarly journals TNF- α augments intratumoural concentrations of doxorubicin in TNF- α -based isolated limb perfusion in rat sarcoma models and enhances anti-tumour effects

2000 ◽  
Vol 82 (4) ◽  
pp. 973-980 ◽  
Author(s):  
A H van der Veen ◽  
J H W de Wilt ◽  
A M M Eggermont ◽  
S T van Tiel ◽  
A L B Seynhaeve ◽  
...  
Keyword(s):  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Tnf Α

Randomized Multicenter Trial of Hyperthermic Isolated Limb Perfusion With Melphalan Alone Compared With Melphalan Plus Tumor Necrosis Factor: American College of Surgeons Oncology Group Trial Z0020

2006 ◽  
Vol 24 (25) ◽  
pp. 4196-4201 ◽  
Author(s):  
Wendy R. Cornett ◽  
Linda M. McCall ◽  
Rebecca P. Petersen ◽  
Merrick I. Ross ◽  
Henry A. Briele ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Response Rate ◽  
Complete Response Rate ◽  
Locally Advanced ◽  
Complete Response ◽  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Tnf Α ◽  
Necrosis Factor

Purpose To determine in a randomized prospective multi-institutional trial whether the addition of tumor necrosis factor alpha (TNF-α) to a melphalan-based hyperthermic isolated limb perfusion (HILP) treatment would improve the complete response rate for locally advanced extremity melanoma. Patients and Methods Patients with locally advanced extremity melanoma were randomly assigned to receive melphalan or melphalan plus TNF-α during standard HILP. Patient randomization was stratified according to disease/treatment status and regional nodal disease status. Results The intervention was completed in 124 patients of the 133 enrolled. Grade 4 adverse events were observed in 14 (12%) of 129 patients, with three (4%) of 64 in the melphalan-alone arm and 11 (16%) of 65 in the melphalan-plus-TNF-α arm (P = .0436). There were two toxicity-related lower extremity amputations in the melphalan-plus-TNF-α arm, and one disease progression–related upper extremity amputation in the melphalan-alone arm. There was no treatment-related mortality in either arm of the study. One hundred sixteen patients were assessable at 3 months postoperatively. Sixty-four percent of patients (36 of 58) in the melphalan-alone arm and 69% of patients (40 of 58) in the melphalan-plus-TNF-α arm showed a response to treatment at 3 months, with a complete response rate of 25% (14 of 58 patients) in the melphalan-alone arm and 26% (15 of 58 patients) in the melphalan-plus-TNF-α arm (P = .435 and P = .890, respectively). Conclusion In locally advanced extremity melanoma treated with HILP, the addition of TNF-α to melphalan did not demonstrate a significant enhancement of short-term response rates over melphalan alone by the 3-month follow-up, and TNF-α plus melphalan was associated with a higher complication rate.

Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalan

2011 ◽  
Vol 103 (5) ◽  
pp. 371-379 ◽  
Author(s):  
Florian Grabellus ◽  
Corinna Kraft ◽  
Sien-Yi Sheu-Grabellus ◽  
Sebastian Bauer ◽  
Lars E. Podleska ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Isolated Limb Perfusion ◽  
Tumor Vascularization ◽  
Limb Perfusion ◽  
Tnf Α

Size-Based Clinical Response Evaluation is Insufficient to Assess Clinical Response of Sarcomas Treated with Isolated Limb Perfusion with TNF-α and Melphalan

2012 ◽  
Vol 19 (11) ◽  
pp. 3375-3385 ◽  
Author(s):  
Florian Grabellus ◽  
Eleni Stylianou ◽  
Lale Umutlu ◽  
Sien-Yi Sheu ◽  
Nils Lehmann ◽  
...  
Keyword(s):  
Clinical Response ◽  
Isolated Limb Perfusion ◽  
Response Evaluation ◽  
Limb Perfusion ◽  
Tnf Α

Isolated limb perfusion (ILP) with TNF-α for melanoma

1995 ◽  
Vol 5 ◽  
pp. 45
Author(s):  
D. Liénard ◽  
A. Eggermont ◽  
B. Kroon ◽  
H. Schraffordt Koops ◽  
F. Lejeune
Keyword(s):  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Tnf Α

Technology Insight: utility of TNF-α-based isolated limb perfusion to avoid amputation of irresectable tumors of the extremities

2006 ◽  
Vol 3 (2) ◽  
pp. 94-103 ◽  
Author(s):  
Dirk J Grünhagen ◽  
Johannes HW de Wilt ◽  
Timo LM ten Hagen ◽  
Alexander MM Eggermont
Keyword(s):  
Isolated Limb Perfusion ◽  
Limb Perfusion ◽  
Tnf Α
Sign in / Sign up

Export Citation Format

Share Document