scholarly journals Relation of impaired energy metabolism to apoptosis and necrosis following transient cerebral hypoxia-ischaemia

1998 ◽  
Vol 5 (4) ◽  
pp. 321-329 ◽  
Author(s):  
Huseyin Mehmet ◽  
Xue Yue ◽  
Juliet Penrice ◽  
Ernest Cady ◽  
John C Wyatt ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cerebral Hypoxia ◽  
Apoptosis And Necrosis ◽  
Impaired Energy Metabolism

Impaired energy metabolism of lymphocytes in cirrhotics after hepatectomy

1992 ◽  
Vol 52 (2) ◽  
pp. 184-190 ◽  
Author(s):  
Shingo Iwata ◽  
Hiroto Egawa ◽  
Hiroshi Higashiyama ◽  
Ryuzaburo Kagawa ◽  
Yasuyuki Shimahara ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Impaired Energy Metabolism

Impaired energy metabolism as an initial step in the mechanism for 6-aminonicotinamide-induced limb malformation

Development ◽  
1980 ◽  
Vol 59 (1) ◽  
pp. 217-222
Author(s):  
Yal C. Sheffield ◽  
Robert E. Seegmiller
Keyword(s):  
Amino Acid ◽  
Energy Metabolism ◽  
Chick Embryo ◽  
Chondroitin Sulfate ◽  
Atp Synthesis ◽  
Initial Step ◽  
Chick Embryos ◽  
Impaired Energy Metabolism ◽  
All Treatment

The analogue and antagonist of nicotinamide, 6-aminonicotinamide (6-AN), impairs cartilage formation and results in shortening of the limbs when administered to chick embryos. Studies have shown that 6-AN forms an abnormal NAD analogue which inhibits the activity of NAD-dependent enzymes associated with production of ATP. To determine if an effect on ATP synthesis might be associated with the mechanism of teratogenesis in the chick embryo, ATP levels of cartilage from day-8 chick embryos treated in vitro were assayed in relation to biosynthesis of protein, DNA and chondroitin sulfate. Incorporation of 35SO4− was inhibited by 6 h of treatment with 10 µg/ml of 6-AN, whereas incorporation of [3H]thymidine and [3H]amino acid was not inhibited until 12 h. Incorporation of [3H]- glucosamine was increased at all treatment times. A decrease in the level of ATP preceded any detectable inhibition of precursor incorporation. These results are consistent with the hypothesis that 6-AN inhibits chondroitin sulfate synthesis through a reduction in the level of ATP in chondrocytes.

scholarly journals Lactate rescues neuronal sodium homeostasis during impaired energy metabolism

Channels ◽  
2015 ◽  
Vol 9 (4) ◽  
pp. 200-208 ◽  
Author(s):  
Claudia Karus ◽  
Daniel Ziemens ◽  
Christine R Rose
Keyword(s):  
Energy Metabolism ◽  
Sodium Homeostasis ◽  
Impaired Energy Metabolism

scholarly journals Relation of Energy Metabolism To Apoptosis Following Cerebral Hypoxia-Ischaemia (Hi)

1997 ◽  
Vol 42 (3) ◽  
pp. 386-386
Author(s):  
Huseyin Mehmet ◽  
Xu Yue ◽  
Juliet Penrice ◽  
Emest B Cady ◽  
John S Wyatt ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cerebral Hypoxia

scholarly journals Impaired Energy Metabolism after Co-Exposure to Leadand Ethanol

2005 ◽  
Vol 96 (6) ◽  
pp. 475-479 ◽  
Author(s):  
Suresh Kumar Verma ◽  
Raina Dua ◽  
Kiran Dip Gill
Keyword(s):  
Energy Metabolism ◽  
Impaired Energy Metabolism
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