Relationship of blood pressure, heart rate and behavioral mood state to norepinephrine kinetics in younger and older men following caffeine ingestion

The purpose of this study was to examine the age-related differences in blood pressure, heart rate, and behavioral mood state after caffeine ingestion in younger and older women. Using a placebo-controlled, double-blind design, 10 younger (Y; 18–22 years) and 10 older (O; 50–67 years) healthy women who were moderate consumers of caffeine (self-reported mean intake: Y, 139 ± 152 mg·day–1; O, 204 ± 101 mg·day–1) were investigated. All volunteers were characterized for fasting plasma glucose, insulin, free-fatty acids and caffeine levels, body composition, cardiovascular fitness, physical activity, and energy intake. Before and after placebo and caffeine ingestion (5 mg·kg–1 fat-free mass; ~208–270 mg) test days, the following variables were measured in all subjects: plasma caffeine levels, heart rate, blood pressure, and behavioral mood state. Results showed that, following caffeine ingestion: (i) both systolic and diastolic blood pressure (SBP and DBP, respectively) increased significantly (p < 0.05) in the older women (SBP, 128.4 ± 14.2 vs. 132.1 ± 13.0 mm Hg (3%); DBP, 80.2 ± 6.9 vs. 83.4 ± 7.5 mm Hg (4%), whereas only DBP increased in the youger women (67.1 ± 4.7 vs. 69.9 ± 5.4 mm Hg (4.2%); p < 0.05); (ii) heart rate decreased significantly (Y, 59.2 ± 8.7 to 53.9 ± 10.6 beats·min–1 (p < 0.05); O, 61.9 ± 9.2 to 59.2 ± 8.4 beats·min–1 (p < 0.05)) in both groups; and (iii) self-reported feelings of tension and vigor increased and feelings of fatigue decreased (p < 0.05) in younger women, whereas depression decreased (p ≤ 0.05) in older women. Self-reported level of physical activity was inversely related to change in DBP following caffeine ingestion in younger women. In conclusion, blood pressure response is augmented and subjective feelings of behavioral mood state are attenuated to a greater degree in older than in younger women following acute caffeine ingestion. Less physically active younger women are more vulnerable to the pressor response to caffeine than more active younger women. It should be noted that these findings are limited to moderate consumers of caffeine who abstained for 48 h prior to testing, and who ingested caffeine in pill form (~240 mg).

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Relationship of Ambulatory Blood Pressure and the Heart Rate Profile with Renal Function Parameters in Hypertensive Patients with Chronic Kidney Disease

Clinical and Experimental Hypertension ◽

10.3109/10641963.2012.681082 ◽

2012 ◽

Vol 34 (4) ◽

pp. 264-269 ◽

Cited By ~ 9

Author(s):

Tomohiko Kanaoka ◽

Kouichi Tamura ◽

Masato Ohsawa ◽

Mai Yanagi ◽

Sona Haku ◽

...

Keyword(s):

Blood Pressure ◽

Chronic Kidney Disease ◽

Heart Rate ◽

Renal Function ◽

Kidney Disease ◽

Ambulatory Blood Pressure ◽

Hypertensive Patients ◽

Rate Profile ◽

Relationship Of

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PM337 Relationship of age and underweight with systolic and diastolic blood pressure, pulse pressure and heart rate among blacks schoolchildren in Central Africa Country

Global Heart ◽

10.1016/j.gheart.2014.03.1690 ◽

2014 ◽

Vol 9 (1) ◽

pp. e130

Author(s):

Bertrand F. Ellenga Mbolla ◽

Thierry R. Gombet ◽

Annie R. Okoko ◽

Christian M. Koula Landa ◽

suzy-Gisèle Kimbally-Kaky ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Diastolic Blood Pressure ◽

Pulse Pressure ◽

Pressure Pulse ◽

Central Africa ◽

Relationship Of

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Relationship of 24-hour ambulatory blood pressure and heart rate with markers of hepatic function in cirrhotic patients

BMC Gastroenterology ◽

10.1186/1471-230x-10-143 ◽

2010 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Dimitris G Tzamouranis ◽

Alexandra Alexopoulou ◽

Spyros P Dourakis ◽

George S Stergiou

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Ambulatory Blood Pressure ◽

Hepatic Function ◽

Cirrhotic Patients ◽

Relationship Of

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Associations of Blood Pressure and Heart Rate and Their Contribution to the Development of Cardiovascular Complications and All-Cause Mortality in the Russian Population of 25-64 Years

Rational Pharmacotherapy in Cardiology ◽

10.20996/1819-6446-2020-10-02 ◽

2020 ◽

Vol 16 (5) ◽

pp. 759-769

Author(s):

S. A. Shalnova ◽

V. A. Kutsenko ◽

A. V. Kapustina ◽

E. B. Yarovaya ◽

Yu. A. Balanova ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Cardiovascular Complications ◽

Adverse Outcomes ◽

Average Value ◽

Risk Of Mortality ◽

The Right ◽

Relationship Of ◽

The Relationship

Aim. To study the relationship of blood pressure (BP) and heart rate (HR) in a sample of men and women 25-64 years old and their predictive value for the development of fatal and non-fatal cardiovascular diseases (CVD) and mortality from all causes.Material and methods. Prospective observation was for cohorts of the population aged 25-64 years from 11 regions of the Russian Federation. 18,251 people were included in the analysis. Each participant gave written informed consent. All surveyed persons were interviewed with a standard questionnaire. BP was measured on the right hand with an automatic tonometer. BP and HR were measured twice with an interval of 2-3 min with the calculation of the average value. The patients were divided into 4 groups: the first group with BP<140/90 ><140/90 mm Hg and HR≤80 beats/min; the second group – BP<140/><140/90 mm Hg and HR>80; the third group – BP≥140/90 mm Hg and HR≤80; the fourth group – BP≥140/90 mm Hg and HR>80 beats/min. Risk factors and cardiovascular history were analyzed as well. Deaths over 6 years of follow-up occurred in 393 people (141 – from CVD). Statistical analysis was performed using the open source R3.6.1 system.Results. A HR>80 beats/min was found in 26.3% of people with BP≥140/90 mm Hg, regardless of medication. Analysis of the associations between HR and BP showed that for every increase in HR by 10 beats/min, systolic BP increases by 3 mm Hg. (p<0.0001). The group with HR>80 beats/min and BP≥140/90 mm Hg had the shortest life expectancy (p<0.001). Adding an increased HR to BP≥140/90 mm Hg significantly><0.001). Adding an increased HR to BP≥140/90 mm Hg significantly worsened the prognosis of patients. Similar results were obtained in the analysis of cardiovascular survival. Elevated BP and elevated HR had the same effect on outcomes, except for the combined endpoint, where the contribution of elevated BP was predominant. However, their combined effect was the largest and highly significant for the development of the studied outcomes, even after adjusting for other predictors. With an increase in HR by every 10 beats/min, the risk of mortality increased statistically significantly by 22%.Conclusion. The prevalence of HR>80 beats/min in people with BP≥140 mm Hg amounted to 26.34%. Every 10 beats/min significantly increases the risk of mortality by 22%. Increased HR with elevated BP leads to increased adverse outcomes.

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Underlying hemodynamic differences are associated with responses to tilt testing

Scientific Reports ◽

10.1038/s41598-021-97503-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Artur Fedorowski ◽

Giulia Rivasi ◽

Parisa Torabi ◽

Madeleine Johansson ◽

Martina Rafanelli ◽

...

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Reflex Response ◽

Tilt Test ◽

Logistic Regression Models ◽

Younger Age ◽

Lower Blood ◽

Unexplained Syncope ◽

Multivariable Analyses ◽

Relationship Of

AbstractAim of this study was to explore whether differences in resting hemodynamic parameters may be associated with tilt test results in unexplained syncope. We analyzed age, gender, systolic (SBP), diastolic blood pressure (DBP) and heart rate (HR) by merging three large databases of patients considered likely to be of vasovagal reflex etiology, comparing patients who had tilt-induced reflex response with those who did not. Tilt-induced reflex response was defined as spontaneous symptom reproduction with characteristic hypotension and bradycardia. Relationship of demographics and baseline supine BP to tilt-test were assessed using logistic regression models. Individual records of 5236 patients (45% males; mean age: 60 ± 22 years; 32% prescribed antihypertensive therapy) were analyzed. Tilt-positive (n = 3129, 60%) vs tilt-negative patients had lower SBP (127.2 ± 17.9 vs 129.7 ± 18.0 mmHg, p < 0.001), DBP (76.2 ± 11.5 vs 77.7 ± 11.7 mmHg, p < 0.001) and HR (68.0 ± 11.5 vs 70.5 ± 12.5 bpm, p < 0.001). In multivariable analyses, tilt-test positivity was independently associated with younger age (Odds ratio (OR) per 10 years:1.04; 95% confidence interval (CI), 1.01–1.07, p = 0.014), SBP ≤ 128 mmHg (OR:1.27; 95%CI, 1.11–1.44, p < 0.001), HR ≤ 69 bpm (OR:1.32; 95%CI, 1.17–1.50, p < 0.001), and absence of hypertension (OR:1.58; 95%CI, 1.38–1.81, p < 0.001). In conclusion, among patients with suspected reflex syncope, younger age, lower blood pressure and lower heart rate are associated with positive tilt-test result.

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Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.1997.273.2.r690 ◽

1997 ◽

Vol 273 (2) ◽

pp. R690-R695 ◽

Cited By ~ 10

Author(s):

K. P. Davy ◽

P. P. Jones ◽

D. R. Seals

Keyword(s):

Blood Pressure ◽

Heart Rate ◽

Arterial Blood Pressure ◽

Older Men ◽

Percentage Increase ◽

Burst Frequency ◽

Arterial Blood ◽

Normoxic Control ◽

Baseline Levels ◽

Total Minute

We tested the hypothesis that aging influences the regulation of sympathetic nervous system activity (SNA) and arterial blood pressure during alterations in systemic O2 levels in humans. To accomplish this, we performed direct (intraneural) measurements of SNA to skeletal muscle (MSNA) in 10 young and 7 older healthy normotensive men during room air breathing (normoxic-control), moderate isocapnic hypoxemia [15 min of 10% fractional inspired O2 (FIO2)], and hyperoxemia (10 min of 50% FIO2). After hypoxemia, arterial O2 saturation (SaO2) declined similarly in the young and older men. MSNA (burst frequency and total minute activity) increased significantly (P < 0.05) in both groups. The magnitudes of the absolute increases in MSNA and the delta MSNA/delta SaO2 were not significantly different in the young and older men; however, because of higher normoxic baseline levels, the percentage increases in burst frequency were smaller (P = 0.02) and those for total minute activity tended to be smaller (P = 0.11) in the older men. Arterial blood pressure increased modestly (P < 0.05) and similarly in both groups, although the older men demonstrated a smaller increase in heart rate. After hyperoxemia [corrected], SaO2 increased and MSNA decreased (both P < 0.05) similarly in the young and older men. Arterial blood pressure did not change significantly from normoxic control levels in either group; however, a small (P < 0.05) reduction in heart rate was observed in both groups. In conclusion, aging does not obviously influence the regulation of absolute levels of MSNA or arterial blood pressure during alterations in systemic O2 levels in healthy men, although older men demonstrate a smaller percentage increase in MSNA from their elevated baseline levels, as well as an attenuated tachycardia in response to acute hypoxemia. As such, the present results are consistent with our previous findings on aging and sympathocirculatory control during other types of acute stress in humans.

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