Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis

Men diagnosed and treated for prostate cancer experience severe adverse effects on quality of life (QoL) and metabolic health, some of which may be preventable or reversible with exercise, the benefits of which healthcare providers and patients increasingly acknowledge, though existing evidence on its effects varies in significance and magnitude. We aimed to review the effect of exercise on QoL and metabolic health in a broad prostate cancer population. A systematic search was conducted in nine databases and eligible trials were included in the meta-analytic procedure. All outcomes were stratified into aerobic exercise, resistance exercise, and a combination of both. The review identified 33 randomised controlled trials (2567 participants) eligible for inclusion. Exercise had a borderline small positive effect on cancer-specific QoL (standardised mean difference (SMD) = 0.10, 95% confidence interval (CI) −0.01–0.22), and a moderate to large effect on cardiovascular fitness (SMD = 0.46, 95% CI 0.34–0.59) with aerobic exercise being the superior modality (SMD = 0.60, 95% CI 0.29–0.90). A positive significant effect was seen in lower body strength, whole-body fat mass, general mental health, and blood pressure. No significant effect was seen in fatigue, lean body mass, and general physical health. We thereby conclude that exercise is effective in improving metabolic health in men diagnosed with prostate cancer, with aerobic exercise as the superior modality. The effect of exercise on QoL was small and not mediated by choice of exercise modality.

Physiological and Performance Correlates of Squash Physical Performance

The physiological and performance attributes of elite squash players were investigated. Thirty-one players (21 males, world ranking [WR] 42-594; 10 females, WR 7-182) completed a battery of fitness tests which included an aerobic squash-specific physical performance test (SPPT), repeated-sprint ability (RSA), change-of-direction speed (COD), acceleration (5-m sprint), body composition and force development (countermovement jump) assessments. The SPPT provided a finishing lap score, V̇O2max, average movement economy and the lap corresponding to a blood lactate concentration of 4 mM.L-1. Players were ranked and assigned to HIGH or LOW performance tiers. Two-way ANOVA (performance level*sex) revealed higher ranked players performed better (p < 0.05) for SPPT final lap (d = 0.35), 4 mM.L-1 lap (d = 0.52) and COD (d = 0.60). SPPT displayed a ‘very-large’ correlation with 4 mM.L-1 lap (r = 0.86), ‘large’ correlations with COD (r = 0.79), RSA (r = 0.79), sum-of-7 skinfolds (r = 0.71) and V̇O2max (r = 0.69), and a ‘trivial’ correlation with average movement economy (r = 0.02). Assessments of cardiovascular fitness (i.e. 4 mM.L-1 lap), RSA, COD and body composition appear highly pertinent for performance profiling of squash players. Regular, submaximal assessment of the 4 mM.L-1 lap during the SPPT may offer a practical athlete monitoring approach for elite squash players.

The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study

Healthy aging has been associated with alterations in pulmonary vascular and right ventricular (RV) hemodynamics, potentially leading to RV remodeling. Despite the current evidence suggesting an association between aging and alterations in RV function and higher prevalence of pulmonary hypertension in the elderly, limited data exist on age-related differences in RV structure and biomechanics. In this work, we report our preliminary findings on the effects of healthy aging on RV structure, function, and biomechanical properties. Hemodynamic measurements, biaxial mechanical testing, constitutive modeling, and quantitative transmural histological analysis were employed to study two groups of male Sprague-Dawley rats: control (11 weeks) and aging (80 weeks). Aging was associated with increases in RV peak pressures (+17%, p = 0.017), RV contractility (+52%, p = 0.004), and RV wall thickness (+38%, p = 0.001). Longitudinal realignment of RV collagen (16.4°, p = 0.013) and myofibers (14.6°, p = 0.017) were observed with aging, accompanied by transmural cardiomyocyte loss and fibrosis. Aging led to increased RV myofiber stiffness (+141%, p = 0.003), in addition to a bimodal alteration in the biaxial biomechanical properties of the RV free wall, resulting in increased tissue-level stiffness in the low-strain region, while progressing into decreased stiffness at higher strains. Our results demonstrate that healthy aging may modulate RV remodeling via increased peak pressures, cardiomyocyte loss, fibrosis, fiber reorientation, and altered mechanical properties in male Sprague-Dawley rats. Similarities were observed between aging-induced remodeling patterns and those of RV remodeling in pressure overload. These findings may help our understanding of age-related changes in the cardiovascular fitness and response to disease.

Use of the Behavioral Regulation in Exercise Questionnaire-2 to assess motivation for physical activity in persons with rheumatoid arthritis: an observational study

Arthritis patients may show little motivation for physical activity (PA), resulting in a sedentary lifestyle. The primary objective of the study was to investigate whether motivation for PA and fulfillment of PA recommendations were associated with cardiorespiratory fitness in patients with RA. The exploratory objective was to study whether university students could be used as controls for RA patients in future studies of PA motivation. Peak oxygen uptake (VO2peak) was measured in 93 RA patients. The patients and 354 students filled in the Behavioral Regulation in Exercise Questionnaire-2 (BREQ-2). Data were analyzed using structural equation modeling with adjustment for age and sex. The BREQ-2 scores were also compiled to an overall motivational style “Relative Autonomy Index” as previously published. Mean VO2peak for the RA patients was 32.2 (SD: 9.6) mL × min−1 × kg−1. Only 29 patients (31%) fulfilled the current recommendations for PA. BREQ-2 scores were associated with measured VO2peak (standardized coefficient 0.33, p < 0.001). Whether a person fulfilled the current recommendations for PA was a significant mediator of this effect (standardized coefficients: mediated effect; 0.22, p = 0.001, remaining direct effect; 0.11, p = 0.18). The Relative Autonomy Index also significantly predicted measured VO2peak (standardized coefficient 0.30, p < 0.001). The underlying BREQ-2 factor structure was significantly different between RA patients and university students, and comparison of scores would not be adequate. Motivation for PA was significantly associated with measured VO2peak in RA patients. The effect was mediated by whether the patient fulfilled the current recommendations for PA. Addressing and stimulating motivation is important when intervening to increase PA and cardiovascular fitness in RA patients.

Proprioceptive Training versus Progressive Adaptive Physical Activity on Balance in Subjects with Sub-Acute Stroke

Background: Post-stroke, gait and balance are often affected increasing the risk of fall, social isolation and sedentary lifestyle. Proprioceptive training has always been a part of post-stroke rehabilitation which has seen to improve muscle strength, balance and gait. Progressive adaptive physical activity has also shown to improve balance, cardiovascular fitness and gait after stroke. This study aims to compare the effect of proprioceptive training and progressive adaptive physical activity on balance in sub-acute stroke subjects. Method: 30 subacute stroke subjects were randomly assigned to one of the two groups. Group A received proprioceptive training while Group B received progressive adaptive physical activity for 30 minutes, 3 times a week for eight weeks. Subjects in both the groups were assessed for balance using Berg Balance Scale and Functional Reach Test prior to the intervention and post-intervention. Result: Both the groups showed significant improvement in the pre to post FRT and BBS scores (p<0.001). Post-intervention, when compared between groups, Group A showed better improvement than Group B on the FRT scores (p<0.001) but no difference was seen in the BBS scores (p value>0.05). Conclusion: Proprioceptive training is found to be more effective than the progressive adaptive physical activity in improving balance among sub-acute stroke subjects. Key words: Stroke, Balance, proprioceptive training, progressive adaptive physical activity.

Training-Associated Superior Visuomotor Integration Performance in Elite Badminton Players after Adjusting for Cardiovascular Fitness

Badminton is recognized as the fastest racket sport in the world based on the speed of the birdie which can travel up to 426 km per hour. On the badminton court, players are not only required to track the moving badminton birdie (visual tracking and information integration) but also must anticipate the exact timing to hit it back (temporal estimation). However, the association of training experience related to visuomotor integration or temporal prediction ability remains unclear. In this study, we tested this hypothesis by examining the association between training experience and visuomotor performances after adjusting for age, education, and cardiovascular fitness levels. Twenty-eight professional badminton players were asked to perform a compensatory tracking task and a time/movement estimation task for measuring visuomotor integration and temporal prediction, respectively. Correlation analysis revealed a strong association between training experience and performance on visuomotor integration, indicating badminton training may be promoted to develop visuomotor integration ability. Furthermore, the regression model suggests training experience explains 32% of visuomotor integration performances. These behavioral findings suggest badminton training may facilitate the perceptual–cognitive performance related to visuomotor integration. Our findings highlight the potential training in visuomotor integration may apply to eye–hand coordination performance in badminton sport.

The Importance of Physical Exercise in Cardiovascular Fitness in Breast Cancer Survivors. A Cross-sectional Study: Women in Motion 2.0.”

PurposeTo compare the cardiovascular fitness of breast cancer (BC) survivors with an active lifestyle to those with a sedentary lifestyle. MethodsA cross-sectional study was conducted. Participants were classified into four different groups: sedentary with BC (Sed-BCW), active with BC (Act-BCW), sedentary without BC (Sed-HW) and active without BC (Act-HW). VO2max was estimated by the 6-minute walking test (6MWT); speed was measured by the 35-meter test; isometric strength was measured by dynamometry tests; lower body maximum strength was measured by the squat test; explosive strength was measured by the Sargent Jump Test; balance was measured by the 30-second balance test; and body composition was measured by bioimpedance. ANOVA was used to analyze group differences and post hoc comparisons were developed with the Bonferroni test. ResultsA total of 92 women were recruited. Significant differences were found in VO2max between the Act-BCW and Sed-BCW groups (MeanDif=5.86, p<0.001). No differences in VO2max were observed between the active groups (MeanDif= 0.42, p= 0.753). Related body composition and fat mass levels were significantly lower in the Act-BCW group than in the sedentary groups (Sed-BCW MeanDif= -6.78; p= 0.012 and Sed-HW MeanDif= -12.07; p<0.001) ConclusionsWomen who are Act-BCW can achieve similar values in physical condition as women who are Act-HW and have better values than women in who are sedentary. Moreover, physical exercise might be a stronger determinant of body composition than a previous history of BC.

High Intensity Functional Training (HIFT) Improves Fitness in Recruit Firefighters

Background: Firefighting is a strenuous profession requiring adequate levels of fitness for effective job performance. Providing firefighters with a safe and effective fitness program is essential for optimal performance. The purpose of this project was to examine changes in various parameters of physical fitness and firefighter ability following a 7-week high intensity functional training (HIFT) program. Methods: Participants were male firefighter recruits (N = 89; age = 27.1 ± 4.2 years, height = 1.78 ± 0.1 m, BMI = 28.1 ± 4.2) enrolled in a Basic Operations Firefighter Academy. Fitness and firefighting ability (via the Academy Firefighter Challenge) were assessed at Weeks 1 and 7 of the Academy. Results: Significant improvements in both fitness and firefighter ability were seen following the HIFT program. Specifically, fitness (BMI, cardiovascular fitness, muscular endurance) improved significantly [Hotelling’s T2 = 8.98, F(5, 84) = 150.92, p < 0.001, η2p = 0.90]. Firefighter ability also improved significantly [Hotelling’s T2 = 3.95, F(7, 88) = 46.26, p < 0.001, η2p = 0.80]. Conclusions: Following a 7-week Basic Operations Firefighter Academy that included daily HIFT, significant increases in fitness and firefighting ability were observed. These findings suggest that HIFT appears to be an effective means of improving fitness and firefighting ability in recruit firefighters.

Repetitions of Strenuous Exercise Consistently Increase Paraoxonase 1 Concentration and Activity in Plasma of Average-Trained Men

Objectives. Oxidative stress, induced by physical activity, may stimulate the expression, release, and activity of certain antioxidant enzymes. We investigated the effect of three repeated bouts of strenuous exercise on paraoxonase 1 concentration (PON1c) and paraoxonase activity (PON). Methods. Eleven average-trained healthy men (age 34.0 ± 5.2 years) performed three strenuous exercise tests on a treadmill separated by 72 hours periods of resting. PON1c, PON, ferric-reducing activity of plasma (FRAP), lipid profile, C-reactive protein concentration (CRP), and lactate concentration were determined in plasma. Results. Each exercise bout resulted in similar PON1c, PON, FRAP, and high-density lipoprotein concentration (HDL-C) increments, while PON/HDL-C ratio remained stable in all repetitions. Percentage increments at the bout of each exercise were higher for PON1c (by 64.82% at the first, by 92.9% at the second, and by 77.02% at the third exercise) than for PON (by 6.49% at the first, 10.06% at the second, and by 12.32% at the third exercise). Association was found between preexercise PON and PON1c ( r = 0.56 , p = 0.029 ), pre- ( r = 0.87 , p = 0.00003 ) and postexercise HDL-C ( r = 0.6 , p = 0.0002 ), preexercise PON and cardiovascular fitness level of participants measured as VO2max ( r = 0.39 , p = 0.026 ), and postexercise PON and lactate concentration ( r = 0.44 , p = 0.01 ). Conclusions. PON1c and PON increase during strenuous exercise, yet the effect of exercise on PON1 concentration is more pronounced. PON1 does not show tolerance to physical activity. The enzyme may provide short-term protection from oxidative stress in each exercise bout. PON may depend on exercise load. Cardiovascular fitness levels may be associated with PON1 activity.

Get Moving! Your Brain Will Thank You

Exercise and cardiovascular fitness are important for physical health and well-being. Recent studies show that exercise is associated with cognitive performance across multiple domains including memory, a common complaint for older adults. Data included a ten-word list of delayed recall, a clock drawing activity, and a three-meter walking course derived from the National Health & Aging Trends Study Database (NHATS Round 9). A total of 4977 participants were included in the analysis which was predominantly white (69.7%), non-Hispanic (94.5%), female (59.2%), and between the ages of 70-84 (62.7%). A hierarchical linear regression revealed that performance on the three-meter walking course positively predicted performance on delayed recall, F(4,3999)=300.257, p&lt;.001, and on the clock drawing activity, which is a common screening task for cognitive decline, F(4,3978)=156.433, p&lt;.001; accounting for 23.1% and 13.6% of the variability, respectively, over and above known demographic variables. Findings suggest that fitness may be one of many factors that is associated with memory and overall cognitive decline. These findings are timely as many individuals slowed down as a result of the COVID-19 pandemic, resulting in decreases in exercise and physical activity. Not being physically active or exercising may be related to poorer physical and cognitive health, with specific concerns regarding memory. Taking into consideration the fear and anxiety associated with declining memory in late life, it is crucial to explore this area further along with other factors that may contribute to the association and develop new ways for older adults to exercise safely during the COVID-19 pandemic.