scholarly journals Inhibition of IFN-γ transcription by site-specific methylation during T helper cell development

2006 ◽  
Vol 25 (11) ◽  
pp. 2443-2452 ◽  
Author(s):  
Brendan Jones ◽  
Jianzhu Chen
Keyword(s):  
Cell Development ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Site Specific ◽  
Ifn Γ

The Immunostimulatory Function of IL-12 in T-Helper Cell Development and Its Regulation by TGF-β, IFN-γ and IL-4

1997 ◽  
pp. 70-85 ◽  
Author(s):  
E. Schmitt ◽  
E. R�de ◽  
T. Germann
Keyword(s):  
Cell Development ◽  
T Helper Cell ◽  
Helper Cell ◽  
Tgf Beta ◽  
T Helper ◽  
Ifn Gamma

Regulatory role of IL4 and other cytokines in T helper cell development in an αβ TCR transgenic mouse system

1993 ◽  
Vol 144 (8) ◽  
pp. 620-625 ◽  
Author(s):  
A. O'Garra ◽  
S.E. Macatonia ◽  
C.-S. Hsieh ◽  
K.M. Murphy
Keyword(s):  
Transgenic Mouse ◽  
Cell Development ◽  
T Helper Cell ◽  
Regulatory Role ◽  
Helper Cell ◽  
T Helper ◽  
Mouse System

scholarly journals Interferon γ Stabilizes the T Helper Cell Type 1 Phenotype

2001 ◽  
Vol 194 (2) ◽  
pp. 165-172 ◽  
Author(s):  
Yongkang Zhang ◽  
Ron Apilado ◽  
John Coleman ◽  
Shlomo Ben-Sasson ◽  
Sharon Tsang ◽  
...  
Keyword(s):  
Critical Role ◽  
Interferon Γ ◽  
T Helper Cell ◽  
Helper Cell ◽  
Wild Type ◽  
T Helper ◽  
Helper Cell Type ◽  
Ifn Γ ◽  
Th 1

T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon (IFN)-γ2/− or IFN-γ receptor (IFN-γR)−/− mice resulted in substantial production of IL-4 and other Th2 cytokines. Adding IFN-γ to the priming culture markedly diminished the capacity of Th1-primed IFN-γ2/− cells to express IL-4. Even IFN-γ–producing cells from IFN-γR−/− mice could acquire IL-4–producing capacity. Thus, IFN-γ is not required for the development of IFN-γ–producing capacity, but it plays a critical role in suppressing the IL-4–producing potential of Th1 cells.

Parasites and T helper cell development: Some insights

1994 ◽  
Vol 10 (12) ◽  
pp. 485-488 ◽  
Author(s):  
S.L. Reiner
Keyword(s):  
Cell Development ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

scholarly journals Stroke-induced Immunodeficiency Promotes Spontaneous Bacterial Infections and Is Mediated by Sympathetic Activation Reversal by Poststroke T Helper Cell Type 1–like Immunostimulation

2003 ◽  
Vol 198 (5) ◽  
pp. 725-736 ◽  
Author(s):  
Konstantin Prass ◽  
Christian Meisel ◽  
Conny Höflich ◽  
Johann Braun ◽  
Elke Halle ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
Focal Cerebral Ischemia ◽  
Lymphocyte Activation ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Th2 Cytokine ◽  
Key Factor ◽  
Helper Cell Type ◽  
Ifn Γ

Infections are a leading cause of death in stroke patients. In a mouse model of focal cerebral ischemia, we tested the hypothesis that a stroke-induced immunodeficiency increases the susceptibility to bacterial infections. 3 d after ischemia, all animals developed spontaneous septicemia and pneumonia. Stroke induced an extensive apoptotic loss of lymphocytes and a shift from T helper cell (Th)1 to Th2 cytokine production. Adoptive transfer of T and natural killer cells from wild-type mice, but not from interferon (IFN)-γ–deficient mice, or administration of IFN-γ at day 1 after stroke greatly decreased the bacterial burden. Importantly, the defective IFN-γ response and the occurrence of bacterial infections were prevented by blocking the sympathetic nervous system but not the hypothalamo-pituitary-adrenal axis. Furthermore, administration of the β-adrenoreceptor blocker propranolol drastically reduced mortality after stroke. These data suggest that a catecholamine-mediated defect in early lymphocyte activation is the key factor in the impaired antibacterial immune response after stroke.

Comprehensive Intestinal T Helper Cell Profiling Reveals Specific Accumulation of IFN-γ+IL-17+Coproducing CD4+ T Cells in Active Inflammatory Bowel Disease

2014 ◽  
Vol 20 (12) ◽  
pp. 2321-2329 ◽  
Author(s):  
Anna-Maria Globig ◽  
Nadine Hennecke ◽  
Bianca Martin ◽  
Maximilian Seidl ◽  
Günther Ruf ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Cells ◽  
Bowel Disease ◽  
Cd4 T Cells ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Specific Accumulation ◽  
Inflammatory Bowel ◽  
Ifn Γ

Stability and commitment in T helper cell development

2001 ◽  
Vol 13 (2) ◽  
pp. 242-247 ◽  
Author(s):  
Hélène Asnagli ◽  
Kenneth M Murphy
Keyword(s):  
Cell Development ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper

T Helper Cell Control of B Cell Development and Isotype Expression

1986 ◽  
Vol 1 (2) ◽  
pp. 183-212
Author(s):  
Jacques Thèze ◽  
Lise Leclercq ◽  
Marie-Lise Gougeon
Keyword(s):  
B Cell ◽  
Cell Development ◽  
B Cell Development ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Cell Control ◽  
Isotype Expression

scholarly journals Dietary oxidized oil influences the levels of type 2 T-helper cell-related antibody and inflammatory mediators in mice

2000 ◽  
Vol 84 (6) ◽  
pp. 911-917 ◽  
Author(s):  
Bi-Fong Lin ◽  
Chia-Chun Lai ◽  
Kai-Wei Lin ◽  
Bor-Luen Chiang
Keyword(s):  
Inflammatory Mediators ◽  
T Helper Cell ◽  
Helper Cell ◽  
T Helper ◽  
Oxidized Oil ◽  
Unfavourable Effect ◽  
Microsomal Cytochrome P450 ◽  
Ifn Γ ◽  
Dietary Oil

The aim of this present study was to investigate the effect of amount and degree of oxidation of dietary oil on type 2 T-helper cell (TH)-related immune responses. Four groups of BALB/c mice were fed either 50 g soyabean oil/kg (50-S), 50 g oxidized oil/kg (50-O), 150 g soyabean oil/kg (150-S) or 150 g oxidized oil/kg (150-O). After 14 weeks consuming the experimental diets, the mice were immunized with ovalbumin (OVA) plus Al and antigen-specific immunoglobulin (Ig)E, IgG1 and IgG2a, inflammatory mediators such as prostaglandin (PG) E2 and leukotriene (LT)B4 were determined. Higher hepatic microsomal cytochrome P450 was noted in mice fed 150 g oxidized oil/kg compared with those of other groups. OVA-specific IgG1 and IgE were higher in mice fed 150 g oxidized oil/kg compared with those of the other groups. The data suggested the interleukin (IL)-4: interferon (IFN)-γ ratio was higher in mice fed 50 g dietary oxidized oil/kg compared with that of the 50-S group. The IL-5:IFN-γ ratios were higher in the 150-S and 150-O groups than in the 50-S and 50-O groups. PGE2 and LTB4 produced by macrophages stimulated by lipopolysaccharide were highest in mice in the 150 g oxidized oil/kg group. The data suggested that an increased intake of oxidized oil might exert an unfavourable effect on the TH2 response involved in allergic disease.

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