Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A

Abstract: Tumor Necrosis Factor alpha (TNF-α) is one of the pleiotrophic cytokines that plays a role in the inflammatory process, initiates and activates polymorphonuclears (PMNs), therefore the PMNs can reach the infection site. This study aimed to determine the profile of TNF-α based on body mass index (BMI) among the students of the Faculty of Medicine Unsrat batch 2014. This was a survey study with a cross sectional design. The study population was students of the Faculty of Medicine University of Sam Ratulangi Manado batch 2014. The results showed that samples with BMI 18-18.9 had an average TNF-α level of 69.48 pg/ml; samples with BMI 19-19.9 had an average TNF-α level of 78.04 pg/ml; samples with BMI 20-20.9 had an average TNF-α level of 61.94 pg/ml; samples with BMI 21-21.9 had an average TNF-α level of 64.37 pg/ml; and samples with BMI 22-22.9 had the highest average level of TNF-α which was 78.65 pg/ml. Conclusion: In this study, all students with normal body mass index (BMI) had normal levels of TNF-α, which was 10-100 pg/ml.Keywords: TNF-α, immune system, body mass index (BMI)Abstrak: Tumor necrosis factor alpha (TNF-α) adalah salah satu sitokin pleiotropik yang berperan dalam proses inflamsi, menginisiasi polymorphonuclear (PMN) dan mengaktivasinya sehingga PMN dapat mencapai tempat infeksi. Penelitian ini bertujuan untuk mengetahui profil TNF-α berdasarkan indeks massa tubuh (IMT) pada mahasiswa Fakultas Kedokteran Unsrat angkatan 2014. Jenis penelitian bersifat survei dengan rancangan potong lintang. Populasi penelitian ialah mahasiswa Fakultas Kedokteran Unsrat angkatan 2014. Hasil penelitian memperlihatkan bahwa sampel dengan IMT 18-18,9 memiliki nilai rerata kadar TNF-α 69,48 pg/ml; sampel dengan IMT 19-19,9 memilki nilai rerata kadar TNF-α 78,04 pg/ml; sampel dengan IMT 20-20,9 memiliki nilai rerata kadar TNF-α 61,94 pg/ml; sampel dengan IMT 21-21,9 memiliki nilai rerata kadar TNF-α 64,37 pg/ml; dan sampel dengan IMT 22-22,9 memiliki nilai rerata TNF-α tertinggi yaitu 78,65 pg/ml. Simpulan: Pada penelitian ini, semua mahasiswa Fakultas Kedokteran Unsrat angkatan 2014 dengan IMT normal memiliki kadar TNF-α normal, yaitu 10-100 ml/pg.Kata kunci: TNF-α, sistem imun, indeks massa tubuh (IMT)

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Dietary and Plasma Carboxymethyl Lysine and Tumor Necrosis Factor-α as Mediators of Body Mass Index and Waist Circumference among Women in Indonesia

Nutrients ◽

10.3390/nu11123057 ◽

2019 ◽

Vol 11 (12) ◽

pp. 3057 ◽

Cited By ~ 2

Author(s):

Patricia Budihartanti Liman ◽

Rina Agustina ◽

Ratna Djuwita ◽

Jahja Umar ◽

Inge Permadhi ◽

...

Keyword(s):

Body Mass Index ◽

Waist Circumference ◽

Tumor Necrosis Factor ◽

Body Mass ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Carboxymethyl Lysine ◽

Positive Direct ◽

Factor Α ◽

Necrosis Factor

Dietary and plasma carboxymethyl lysine (dCML, pCML) and plasma tumor necrosis factor-α (pTNF-α) may be associated with obesity in affluent society. However, evidence in women from low-middle income countries with predominantly traditional diets is lacking. We investigated the mediator effects of dCML, pCML and pTNF-α on body mass index (BMI) and waist circumference (WC) among Indonesian women. A cross-sectional study was conducted among 235 non-diabetic, non-anemic and non-smoking women aged 19–50 years from selected mountainous and coastal areas of West Sumatra and West Java. Dietary CML, pCML, pTNF-α were obtained from 2 × 24-h recalls, ultra-performance liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay, respectively. Between-group differences were analyzed by the Chi-square or Mann-Whitney test and mediator effects by Structural Equation Modeling. The medians and interquartile-ranges of dCML, pCML and pTNF-α were 2.2 (1.7–3.0) mg/day, 22.2 (17.2–28.2) ng/mL and 0.68 (0.52–1.00) IU/mL, respectively, and significantly higher in the WC ≥ 80 cm than in the WC < 80 cm group, but not in BMI ≥ 25 kg/m2 compared to BMI < 25 kg/m2 group. Plasma CML and pTNF-α were positively and directly related to WC (β = 0.21 [95% CI: 0.09, 0.33] and β = 0.23 [95% CI: 0.11, 0.35], respectively). Dietary CML that correlated with dry-heat processing and cereals as the highest contributions was positively related to WC (β = 0.33 [95% CI: 0.12, 0.83]). Ethnicity, level of education, intake of fat, and intake of energy contributed to dCML, pCML and pTNF-α, and subsequently affected WC, while only ethnicity contributed to BMI through dCML, pCML and pTNF-α (β = 0.07 [95% CI: 0.01, 0.14]). A positive direct effect of dCML on pCML and of pCML and pTNF-α on WC was seen among Indonesian women. Dietary CML seems to have several paths that indirectly influence the increases in WC if compared to BMI. Thus, intake of CML-rich foods should be reduced, or the foods consumed in moderate amounts to avoid the risk of central obesity in this population.

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