Linear epitopes of colonization factor antigen I and peptide vaccine approach to enterotoxigenic Escherichia coli

1997 ◽  
Vol 19 (1) ◽  
pp. 66-70 ◽  
Author(s):  
F J Cassels ◽  
D L Jarboe ◽  
R H Reid ◽  
A Lees ◽  
C D Deal
Keyword(s):  
Escherichia Coli ◽  
Peptide Vaccine ◽  
Enterotoxigenic Escherichia Coli ◽  
Colonization Factor ◽  
Linear Epitopes ◽  
Vaccine Approach ◽  
Colonization Factor Antigen I ◽  
Factor Antigen

scholarly journals Structural Features of Colonization Factor Antigen I (CFA/I) Pili (Fimbriae) of Enterotoxigenic Escherichia coli

2006 ◽  
Vol 12 (S02) ◽  
pp. 356-357
Author(s):  
X-Q Mu ◽  
SJ Savarino ◽  
Y Akay ◽  
A McVeigh ◽  
F Cassels ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Structural Features ◽  
Enterotoxigenic Escherichia Coli ◽  
Colonization Factor ◽  
Colonization Factor Antigen I ◽  
Factor Antigen

Extended abstract of a paper presented at Microscopy and Microanalysis 2006 in Chicago, Illinois, USA, July 30 – August 3, 2006

scholarly journals Functional analysis of colonization factor antigen I positive enterotoxigenic Escherichia coli identifies genes implicated in survival in water and host colonization

2021 ◽  
Vol 7 (6) ◽  
Author(s):  
Moataz Abd El Ghany ◽  
Lars Barquist ◽  
Simon Clare ◽  
Cordelia Brandt ◽  
Matthew Mayho ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Enterotoxigenic Escherichia Coli ◽  
Mammalian Host ◽  
Content Type ◽  
Colonization Factor ◽  
Lipopolysaccharide Biosynthesis ◽  
Common Causes ◽  
Colonization Factor Antigen I ◽  
Factor Antigen

Enterotoxigenic Escherichia coli (ETEC) expressing the colonization pili CFA/I are common causes of diarrhoeal infections in humans. Here, we use a combination of transposon mutagenesis and transcriptomic analysis to identify genes and pathways that contribute to ETEC persistence in water environments and colonization of a mammalian host. ETEC persisting in water exhibit a distinct RNA expression profile from those growing in richer media. Multiple pathways were identified that contribute to water survival, including lipopolysaccharide biosynthesis and stress response regulons. The analysis also indicated that ETEC growing in vivo in mice encounter a bottleneck driving down the diversity of colonizing ETEC populations.

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