Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity

Leukemia ◽

10.1038/sj.leu.2402831 ◽

2003 ◽

Vol 17 (3) ◽

pp. 604-611 ◽

Author(s):

Z Zhu ◽

K Hattori ◽

H Zhang ◽

X Jimenez ◽

D L Ludwig ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Animal Model ◽

Biological Activity ◽

Growth Factor ◽

Growth Factor Receptor ◽

Human Leukemia ◽

Vascular Endothelial ◽

Antibody Affinity ◽

Human Antibodies ◽

Endothelial Growth Factor

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Synthesis and biological activity of N4-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2010.03.052 ◽

2010 ◽

Vol 18 (10) ◽

pp. 3575-3587 ◽

Author(s):

Aleem Gangjee ◽

Sonali Kurup ◽

Michael A Ihnat ◽

Jessica E. Thorpe ◽

Satyendra S. Shenoy

Keyword(s):

Vascular Endothelial Growth Factor ◽

Biological Activity ◽

Growth Factor ◽

Antitumor Agents ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.01.040 ◽

2013 ◽

Vol 21 (7) ◽

pp. 1857-1864 ◽

Author(s):

Aleem Gangjee ◽

Nilesh Zaware ◽

Sudhir Raghavan ◽

Bryan C. Disch ◽

Jessica E. Thorpe ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Biological Activity ◽

Growth Factor ◽

Growth Factor Receptor ◽

Antiangiogenic Agents ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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HCPTPA, a Protein Tyrosine Phosphatase That Regulates Vascular Endothelial Growth Factor Receptor-mediated Signal Transduction and Biological Activity

Journal of Biological Chemistry ◽

10.1074/jbc.274.53.38183 ◽

1999 ◽

Vol 274 (53) ◽

pp. 38183-38188 ◽

Author(s):

Liwen Huang ◽

Sabita Sankar ◽

Charles Lin ◽

Christopher D. Kontos ◽

Alfred D. Schroff ◽

...

Keyword(s):

Signal Transduction ◽

Vascular Endothelial Growth Factor ◽

Biological Activity ◽

Growth Factor ◽

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Protein Tyrosine ◽

Endothelial Growth Factor

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Inhibition of Both the Autocrine and the Paracrine Growth of Human Leukemia with a Fully Human Antibody Directed Against Vascular Endothelial Growth Factor Receptor 2

Leukemia & Lymphoma ◽

10.1080/10428190410001712225 ◽

2004 ◽

Vol 45 (9) ◽

pp. 1887-1897 ◽

Author(s):

Haifan Zhang ◽

Yiwen Li ◽

Hongli Li ◽

Rajiv Bassi ◽

Xenia Jimenez ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Human Antibody ◽

Human Leukemia ◽

Vascular Endothelial ◽

Endothelial Growth Factor

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Fortgeschrittenes medulläres Schilddrüsenkarzinom: Vandetanib verbessert das progressionsfreie Überleben

Onkologische Welt ◽

10.1055/s-0038-1631032 ◽

2012 ◽

Vol 03 (02) ◽

pp. 93-92

Author(s):

Alexander Kretzschmar

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Phase Iii ◽

Vascular Endothelial ◽

Medulläres Schilddrüsenkarzinom ◽

Epidermal Growth ◽

Endothelial Growth Factor

Vandetanib ist ein oraler Hemmer des RET-Kinase-, VEGF (Vascular Endothelial Growth Factor Receptor)- und EGFR (Epidermal Growth Factor Receptor)-Signalwegs. In einer zulassungsrelevanten, randomisierten, doppelblinden, placebokontrollierten Phase- III-Studie verlängerte der Tyrosinkinasehemmer das progressionsfreie Überleben (PFS) signifikant länger als Placebo.

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Expression des „Epidermal Growth-Factor Receptor“ (EGFR) und des „Vascular Endothelial Growth Factor“ (VEGF) bei Lymphangioleiomyomatose (LAM)

Pneumologie ◽

10.1055/s-2006-934022 ◽

2006 ◽

Vol 60 (S 1) ◽

Author(s):

H Watz ◽

K Engels ◽

M Amthor ◽

D Kirsten ◽

H Magnussen

Keyword(s):

Vascular Endothelial Growth Factor ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Epidermal Growth ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1163678.625451 ◽

2009 ◽

Author(s):

David Bates

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Lymphatic Vessel ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endogenous Inhibitor ◽

Vessel Growth ◽

Alternatively Spliced ◽

Endothelial Growth Factor

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.12828054 ◽

2011 ◽

Author(s):

Asma Nusrat

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.11744956.13740054 ◽

2011 ◽

Author(s):

Richard L Stevens

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Receptor Antagonism ◽

Endothelial Growth Factor ◽

Α2β1 Integrin

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Faculty Opinions recommendation of 111In-bevacizumab imaging of renal cell cancer and evaluation of neoadjuvant treatment with the vascular endothelial growth factor receptor inhibitor sorafenib.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717697854.793153053 ◽

2012 ◽

Author(s):

Hendrik van Poppel ◽

Yuri Tolkach

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Renal Cell Cancer ◽

Cell Cancer ◽

Neoadjuvant Treatment ◽

Growth Factor Receptor ◽

Vascular Endothelial ◽

Endothelial Growth Factor ◽

Receptor Inhibitor

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