scholarly journals Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

Oncogene ◽  
2002 ◽  
Vol 21 (55) ◽  
pp. 8470-8476 ◽  
Author(s):  
Aristotelis Astrinidis ◽  
Timothy P Cash ◽  
Deborah S Hunter ◽  
Cheryl L Walker ◽  
Jonathan Chernoff ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Tuberous Sclerosis ◽  
Tumor Suppressor Gene ◽  
Gene Product ◽  
Tuberous Sclerosis Complex ◽  
Suppressor Gene ◽  
Tumor Suppressor Gene Product ◽  
Cell Adhesion And Migration ◽  
And Migration

scholarly journals E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.

1994 ◽  
Vol 127 (6) ◽  
pp. 2061-2069 ◽  
Author(s):  
J Hülsken ◽  
W Birchmeier ◽  
J Behrens
Keyword(s):  
Cell Adhesion ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Gene Product ◽  
Suppressor Gene ◽  
Cell Junctions ◽  
Beta Catenin ◽  
Tumor Suppressor Gene Product ◽  
Product Forms ◽  
E Cadherin

beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like repeats of beta-catenin; the NH2-terminal domain of beta-catenin mediates the interaction of the alternative E-cadherin and APC complexes to the cytoskeleton by binding to alpha-catenin. Plakoglobin (gamma-catenin), which is structurally related to beta-catenin, mediates identical interactions. We thus show that the APC tumor suppressor gene product forms strikingly similar associations as found in cell junctions and suggest that beta-catenin and plakoglobin are central regulators of cell adhesion, cytoskeletal interaction, and tumor suppression.

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