scholarly journals Germline mutations in fumarate hydratase (FH) do not predispose to prostate cancer

2003 ◽  
Vol 6 (1) ◽  
pp. 12-14 ◽  
Author(s):  
S Bevan ◽  
◽  
S M Edwards ◽  
A Ardern Jones ◽  
A Dowe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Fumarate Hydratase ◽  
Germline Mutations

scholarly journals BRCA Germline Mutations in Prostate Cancer: The Future Is Tailored

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 908
Author(s):  
Felice Crocetto ◽  
Biagio Barone ◽  
Vincenzo Francesco Caputo ◽  
Matteo Fontana ◽  
Ottavio de Cobelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cause Of Death ◽  
Germline Mutations ◽  
The Future

Prostate cancer (PCa) is the second most common neoplasm in men and the fifth leading cause of death worldwide [...]

scholarly journals Comparison of germline mutations in African American and Caucasian men with metastatic prostate cancer

The Prostate ◽  
2021 ◽  
Author(s):  
Elisa M. Ledet ◽  
Earle F. Burgess ◽  
Alexandra O. Sokolova ◽  
Ellen B. Jaeger ◽  
Whitley Hatton ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Metastatic Prostate Cancer ◽  
Germline Mutations ◽  
Caucasian Men

scholarly journals Identification of Two Novel HOXB13 Germline Mutations in Portuguese Prostate Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132728 ◽  
Author(s):  
Sofia Maia ◽  
Marta Cardoso ◽  
Pedro Pinto ◽  
Manuela Pinheiro ◽  
Catarina Santos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Germline Mutations

The role of germline mutations in the BRCA1/2 and mismatch repair genes in men ascertained for early-onset and/or familial prostate cancer

2015 ◽  
Vol 15 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Sofia Maia ◽  
Marta Cardoso ◽  
Paula Paulo ◽  
Manuela Pinheiro ◽  
Pedro Pinto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mismatch Repair ◽  
Early Onset ◽  
Germline Mutations ◽  
Mismatch Repair Genes ◽  
Repair Genes

scholarly journals Risk-adapted approach to prostate cancer screening

2018 ◽  
Vol 14 (2) ◽  
pp. 109-121 ◽  
Author(s):  
A. A. Kirichek ◽  
L. N. Lyubchenko ◽  
V. B. Matveev
Keyword(s):  
Prostate Cancer ◽  
Early Detection ◽  
Germline Mutation ◽  
Prostate Cancer Screening ◽  
Germline Mutations ◽  
Polygenic Inheritance ◽  
Psa Screening ◽  
Psa Testing ◽  
Mutation Carriers ◽  
Brca1 Brca2

Mass prostatic specific antigen (PSA) testing (population-based PSA screening) has remained controversial, nevertheless there are men cohorts likely to benefit from PSA screening. Heritable factors contribute to 60 % risk for developing familial prostate cancer. Despite the fact that its clinical application is challenging due to polygenic inheritance, advances in new generation sequencing technologies permit identifying highly penetrant germline mutations in genes BRCA1, BRCA2, CHEK2, HOXB13 and MMR associated with tremendous increase in risk of developing the prostate cancer. Several germline mutations are associated with clinically aggressiveness of disease and shortened survival. Targeted screening that is based on family history and genomic aberrations should be the next step towards the precision medicine. Men at elevated risk should been performed for early detection are those with familiar history of prostate cancer, or BRCA1, BRCA2, CHEK2, HOXB13 and MMR pathogenic germline mutation carriers, or first line relatives diagnosed with certain types of cancer. Systematic PSA testing in 1–2 years among germline mutation carriers men beginning at age 45 years would contribute to increase in early detection of localized prostate cancer resulting in more chance of curative treatment and improve survival rates

scholarly journals Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer

2017 ◽  
Vol 109 (4) ◽  
Author(s):  
Laurent Briollais ◽  
Hilmi Ozcelik ◽  
Jingxiong Xu ◽  
Maciej Kwiatkowski ◽  
Emilie Lalonde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germline Mutations ◽  
Aggressive Prostate Cancer ◽  
Kallikrein 6

Germline mutations of BRCA1 and BRCA2 genes in Turkish breast, ovarian, and prostate cancer patients

2010 ◽  
Vol 203 (2) ◽  
pp. 230-237 ◽  
Author(s):  
Esra Manguoğlu ◽  
Şefik Güran ◽  
Deniz Yamaç ◽  
Taner Çolak ◽  
Mehmet Şimşek ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Brca1 And Brca2 ◽  
Brca1 And Brca2 Genes

scholarly journals A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer

The Prostate ◽  
2018 ◽  
Vol 78 (8) ◽  
pp. 607-615 ◽  
Author(s):  
Yishuo Wu ◽  
Hongjie Yu ◽  
S. Lilly Zheng ◽  
Rong Na ◽  
Mufaddal Mamawala ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Comprehensive Evaluation ◽  
Germline Mutations

Germline mutations in the Kallikrein 6 region and predisposition for aggressive prostate cancer

2017 ◽  
Vol 16 (3) ◽  
pp. e624-e625
Author(s):  
L. Briollais ◽  
H. Ozcelik ◽  
J. Xu ◽  
M. Kwiatkowski ◽  
E. Lalonde ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Germline Mutations ◽  
Aggressive Prostate Cancer ◽  
Kallikrein 6

Identification of germline mutations in men with early onset prostate cancer.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 5045-5045
Author(s):  
Patrick Pilie ◽  
Anna M. Johnson ◽  
Kimberly A. Zuhlke ◽  
Linda A. Okoth ◽  
Scott Tomlins ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Early Onset ◽  
Germline Mutations
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