scholarly journals Identification of Two Novel HOXB13 Germline Mutations in Portuguese Prostate Cancer Patients

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132728 ◽  
Author(s):  
Sofia Maia ◽  
Marta Cardoso ◽  
Pedro Pinto ◽  
Manuela Pinheiro ◽  
Catarina Santos ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Germline Mutations

Germline mutations of BRCA1 and BRCA2 genes in Turkish breast, ovarian, and prostate cancer patients

2010 ◽  
Vol 203 (2) ◽  
pp. 230-237 ◽  
Author(s):  
Esra Manguoğlu ◽  
Şefik Güran ◽  
Deniz Yamaç ◽  
Taner Çolak ◽  
Mehmet Şimşek ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Brca1 And Brca2 ◽  
Brca1 And Brca2 Genes

scholarly journals PD20-04 GERMLINE MUTATIONS IN DNA REPAIR GENES ARE INDEPENDENT PREDICTORS OF GRADE RECLASSIFICATION IN ACTIVE SURVEILLANCE FOR PROSTATE CANCER PATIENTS

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
H. Ballentine Carter ◽  
Mufaddal Mamawala ◽  
Tricia Landis ◽  
Kathleen Wiley ◽  
Isaacs William B. ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Cancer Patients ◽  
Active Surveillance ◽  
Germline Mutations ◽  
Dna Repair Genes ◽  
Repair Genes

Abstract B075: Defining germline mutations of DNA damage repair genes in African American prostate cancer patients

2020 ◽  
Author(s):  
Kevin Babcock ◽  
Xijun Zhang ◽  
Matthew Wilkerson ◽  
Clifton L. Dalgard ◽  
Shyh-Han Tan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
African American ◽  
Cancer Patients ◽  
Dna Damage Repair ◽  
Germline Mutations ◽  
Damage Repair ◽  
Repair Genes

MP09-03 GERMLINE MUTATIONS IN HIGH RISK PROSTATE CANCER PATIENTS

2020 ◽  
Vol 203 ◽  
pp. e116
Author(s):  
Joel Wackerbarth* ◽  
John Richgels ◽  
Olivia Vizzini ◽  
Sara Nielsen ◽  
Russell Szmulewitz ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Cancer Patients ◽  
Germline Mutations ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

Germline mutations in DNA repair genes in a large series of unselected Chinese prostate cancer patients.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e17523-e17523
Author(s):  
Yu Wei ◽  
Yao Zhu ◽  
Junlong Wu ◽  
Dingwei Ye ◽  
Hao Zeng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Repair ◽  
Genetic Testing ◽  
Family History ◽  
High Risk ◽  
Cancer Patients ◽  
Germline Mutations ◽  
Dna Repair Genes ◽  
History Of ◽  
Repair Genes

e17523 Background: Germline DNA repair gene (DRG) mutations has emerged as a potential determinant of cancer risk and therapeutic response in PCa. Despite substantial advances in delineating the germline mutation in DRGs among Caucasian population, the prevalence of mutations in DRGs are largely unknown among a large series of unselected prostate cancer patients in Chinese population. Methods: We enrolled 1003 prostate cancer patients from three different hospitals in China, unselected for family history of cancer or age at diagnosis. All patients received germline genetic testing using a clinician-selected multi-gene panel. The 18 DNA repair genes and HOXB13, which has established or emerging potential clinical actionability in PCa, were analyzed in our study. Results: A total of 94 (9.7%) deleterious germline mutations were identified among the 1003 unselected prostate cancer patients. Of these, 5.6% patients carried a BRCA1 or BRCA2 mutations (5.2% in BRCA2 and 0.4% in BRCA1), 3.6% patients carried other DRG mutations (including 10 genes) and 0.5% patients carried HOXB13 mutations. Besides, variants with uncertain significance (VUS) were found in approximately 45% patients. We also divided 633 metastatic PCa patients into 542 de novo metastastic PCa and 91 recurrent metastastic PCa and found mutation frequencies did not differ between these two groups (9.0% vs 11.6%, p = 0.6). Patients with younger age of onset or family history of cancers were more likely to harbour germline mutations in DRGs. However, the rate of germline mutations were still at a high level for patients more than 70 years old (6.7%) and patients without family history of cancers (7.5%). There is no statistically significant difference in the mutation frequencies between patients with metastasis and without metastasis (7.5% vs 9.2%, p = 0.4), which may be because 85% patients without metastasis in our cohort were in high to very high risk group or have lymph node metastasis. Conclusions: To our knowledge, our study reported the largested series of Chinese PCa patients who received germline genetic testing. Our study provided a rationality for germline genetic testing criteria from high risk to metastastic PCa regardless of family history considering the high proportion. In addition, we recommended a multigene panel covering 13 genes ( ATM, BRCA1, BRCA2, CHEK2, FANCA, HOXB13, MSH2, MSH6, NBN, PALB2, RAD51C, RAD51D, TP53) in China. Nevertheless, the high prevalence of VUS (45%) in Chinese PCa patients warrant further efforts.

Prevalence of comprehensive DNA damage repair gene germline mutations in Chinese prostate cancer patients

2020 ◽  
Vol 148 (3) ◽  
pp. 673-681
Author(s):  
Junlong Wu ◽  
Yu Wei ◽  
Jian Pan ◽  
Shengming Jin ◽  
Weijie Gu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Dna Damage Repair ◽  
Germline Mutations ◽  
Repair Gene ◽  
Damage Repair

Analysis of BRCA germline mutations in Chinese prostate cancer patients

2021 ◽  
Vol 79 ◽  
pp. S603
Author(s):  
W. Chen ◽  
W. Xia ◽  
S. Xue ◽  
H. Huang ◽  
Q. Lin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Germline Mutations

390: Durable Cancer Control in High Risk Prostate Cancer Patients Treated with Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 130-130
Author(s):  
Markus Graefen ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Felix K.-H. Chun ◽  
Alwyn M. Reuther ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Cancer Control ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

598: Increased Risk of Newly Diagnosed Comorbidities in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

2007 ◽  
Vol 177 (4S) ◽  
pp. 200-200 ◽  
Author(s):  
Andrea Gallina ◽  
Pierre I. Karakiewicz ◽  
Jochen Walz ◽  
Claudio Jeldres ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Newly Diagnosed ◽  
Increased Risk
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